Protein Alignment dia and Fmnl1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_001426911.1
• Gene: Fmnl1 / 287746
• RGDID: 1311042
• Length: 1101
• Species: Rattus norvegicus
• Alignment Length: 1186
• Identity: 285/1186 - (24%)
• Similarity: 483/1186 - (40%)
• Gaps: 318/1186 - (26%)

  Fly    70 SVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE---KPIDY 131
            :..||:.:|..::..||:|.||.:.|.....|::.::|            ....||:   .|..|
  Rat    31 AAGELEERFTRVLNCMNLPPDKVQLLSQYDNEKKWELI------------CDQERFQVKNPPAAY 83

  Fly   132 VE----YLQNG--------------------EHSTHKVYQCVESLRVALTSNPISWIKEF---GV 169
            ::    ||..|                    :.||    |.:..|..:|.:|.|.|::||   ..
  Rat    84 IQKLKSYLDTGGVSRKVATDWMSNLGFKRRVQEST----QVLRELETSLRTNHIGWVQEFLNEEN 144

  Fly   170 AGIGTIEKLLARSKNNASYEKIEFE---------------------------------------- 194
            .|:..:.:.||.::.:.:|:....|
  Rat   145 RGLDVLLEYLAFAQCSVAYDMESTENVASGTEKNKPLEQSVEDLSKAPPSSVPKSRLTIKCPPSP 209

  Fly   195 -------------------------AIRCLKAIMNNTWGLNVVLNPDQHSVVLLLAQSLDPRKPQ 234
                                     .|.||:||||...|.::|:|  ..:.|..:|.||:.:.|:
  Rat   210 RLTPAHSRKALRNSRIVSQKDDVHVCIMCLRAIMNYQSGFSLVMN--HPACVNEIALSLNNKNPR 272

  Fly   235 TMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFK----ASERFRPIVDALFASDQQDPKRDL 295
            |....|:|||:.|:|  |.|::.:|.|.     .:||    ...||..::: .|.::..:....:
  Rat   273 TKALVLELLAAVCLV--RGGHDIILAAF-----DNFKEVCGEQHRFEKLME-YFRNEDSNIDFMV 329

  Fly   296 ACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFKIFNEIRED 360
            ||  :.|||.:.::..::|||:.|:.|...:|    ||.:.:.:..:.::.||...:.:
  Rat   330 AC--MQFINIVVHSVENMNFRVFLQYEFTHLG----LDLYLERLRLTESDKLQVQIQAY------ 382

  Fly   361 DFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLSILQHL-----------LYIRDDFY 414
                    .|||          ||| ..|:.:|.::.   ::|:|:           ..:||...
  Rat   383 --------LDNV----------FDV-GTLLEETETKN---AVLEHMEELQEQVATLTERLRDTEN 425

  Fly   415 FRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKKIEQL 479
            ...|....:|:.:||.                ..:...|.:...|......|:|..|.||.....
  Rat   426 DSMAKIAELEKQLSQA----------------RKELETLRERFSESTPMVTSRRIPEPEKVPAPT 474

  Fly   480 ESAKQEAEAKAAHLEEK--VKLMEA-----------------NGVAAPSP----------NKLPK 515
            .......|.|...||||  ::::..                 :|..||:|          ..:|:
  Rat   475 VVRPSALELKVEELEEKGLIRILRGPGDVVSIEILPGAAATPSGDDAPAPRVSTDSPSTAESVPE 539

  Fly   516 VNIPMPPPPPGGGGAPPPPP------------------PPMPGRAGGGPPPPPPPPMPGRAGGPP 562
            ...|.|||||     |||||                  ||:||.|.    |||.||:||..  ||
  Rat   540 AASPTPPPPP-----PPPPPLPNLQSQQEALPSAPPLAPPLPGCAA----PPPAPPLPGDL--PP 593

  Fly   563 PPPPPP-GMGGPPPPPMPGMMRPGGGPPP--PPMMMGPMVPVLPHGLKPKKKWDVKNPMKRANWK 624
            |||||| |..||.|||.|        |||  ||.::|...|.:..|:|.||....|..|...||.
  Rat   594 PPPPPPLGTDGPVPPPPP--------PPPGGPPDILGGQDPEIGPGVKAKKPIQTKFRMPLLNWV 650

  Fly   625 AIVPAKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVD----KPTTLTKKNVDLR 685
            |:.|::::...| .:..::|:.|:..:.:...:|.:    |.|..::|    |..|..|......
  Rat   651 ALKPSQITGTVF-TELNDEKVLQELDMNDFEEQFKT----KSQGPSLDISALKGKTAHKAPTKAT 710

  Fly   686 VLDSKTAQNLAIMLGGSLKHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEH---LKRLQEI 747
            ::::..|:||||.|...  :|..::|...:...|...||.:.|:.|.::||....   :.|.::.
  Rat   711 LIEANRAKNLAITLRKG--NLGADRICEAIETYDLQTLSLDFLELLTRFLPTDYERSLIARFEKE 773

  Fly   748 KAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSK 812
            :...|.|...::|......|:||..|::.|.|...:.|..|.:.|.:.|..||...|::|.|..:
  Rat   774 QRPMEELSEEDRFMLRFSRIQRLPERMNTLTFLGNFPDTAQLLMPQLNAIIAASISIKSSDKLRQ 838

  Fly   813 ILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDD 877
            |||::|..|||||| ||..||:||.:..|..|...|..|.||||||||..::.:|:|....|:.|
  Rat   839 ILEIVLAFGNYMNS-SKRGAAYGFRLQSLDALLEMKSTDRKQTLLHYLVKVIAEKYPQLTGFHSD 902

  Fly   878 LSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDKFSEVMGKFAEECRQQVDVLG 942
            |..::||..|::|::...:|.:...:     :|...:..:.||   ..|:.:|.......:|.|.
  Rat   903 LHFLDKAGSVSLDSVLGDVRSLQRGL-----ELTQREFVRQDD---CLVLKEFLRANSPTMDKLL 959

  Fly   943 KMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAHNDNVRVREELEKKRRLQEARE 1007
            ......::.|:.:.||:..:|...:...||:....|..|::.|       .:|:|:.:: :.|.:
  Rat   960 ADSKTAQEAYESVVEYFGENPKTTSPSMFFSLFSRFTKAYKKA-------EQEVEQWKK-EAAAD 1016

  Fly  1008 QSAREQ--------QERQQRKKAVVDMDAPQTQE---------GVMDSLLEALQ--------TGS 1047
            .|.||:        :.|:|:...:.::...|.:|         |.::.::..|:        ||
  Rat  1017 TSGREEPPAPKSPPKARRQQMDLISELKRKQLKEPLIYESDRDGAIEDIITDLRNQPYIRADTG- 1080

  Fly  1048 AFGQRNRQARRQRPAG 1063
                  |::.|:||.|
  Rat  1081 ------RRSARRRPPG 1090

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	53/272 (19%)
		Drf_FH3	253..453	CDD:461885	39/214 (18%)
		FH2	608..983	CDD:396655	105/381 (28%)
Fmnl1	NP_001426911.1	None