Protein Alignment dia and frl-1

DIOPT Version :10

• Sequence 1: NP_001246113.1
• Gene: dia / 35340
• FlyBaseID: FBgn0011202
• Length: 1098
• Species: Drosophila melanogaster
• Sequence 2: NP_497505.4
• Gene: frl-1 / 175346
• WormBaseID: WBGene00021698
• Length: 1200
• Species: Caenorhabditis elegans
• Alignment Length: 1284
• Identity: 303/1284 - (23%)
• Similarity: 490/1284 - (38%)
• Gaps: 329/1284 - (25%)

  Fly     2 RLKKLGMSRHEKTKSTGGGLLDSLFGRPSKSKGGTISSGTLAHGGRPVSADNYVV-----PGVED 61
            :|::....:.:|.|...||..:||  |.|.|....|.|..::...:.......:|     |.:..
 Worm    36 KLRRTFGVKPKKKKEDPGGSANSL--RRSNSTSSDIRSRRISSVIQSRECSTMIVGPTVAPPMPP 98

  Fly    62 FEQYIQQLSVAELDAKFLEIIEDMNIPKDKREPLLAKSKEERQKMIMWHLKGKNSLERSANSRFE 126
            .||         ||..|.::::.|::|.||...|.....:::.|:|         :::....:..
 Worm    99 QEQ---------LDKMFDDVLKHMDLPVDKLRILRGYDNDKKWKLI---------VDQQVAKQVT 145

  Fly   127 KPIDYVE-------------YLQNGEHSTHKVYQCV-ESLRVALTSNPISWIKEF-GVAGIGTIE 176
            .|..|:|             .|:|.|....:....| ..:.::|.:|.:.|:.|| ....:| :.
 Worm   146 PPAKYLEKLSYFLDKKLLKKALKNKEIGVDETSTSVLRHIEISLRTNSVDWVFEFLNTPNLG-LR 209

  Fly   177 KLL-----------------------------ARS---------------KNNASYE-------- 189
            ||:                             |.|               .:|:|||
 Worm   210 KLVDYMRTLLADCAPSVPSTSSGLPAGFLNSTANSSVGANNNHSSLNESPSHNSSYEMSTTTTAN 274

  Fly   190 -------------------------KIEFEAI-------RCLKAIMNNTWGLNVVLNPDQHSVVL 222
                                     |...||:       .||:|||||..|...|.  .....:.
 Worm   275 TSNSFDATANLLKKGPLTISKGKVAKTTGEAVDDIHICMMCLRAIMNNKQGFQQVF--ADTDAIY 337

  Fly   223 LLAQSLDPRKPQTMCEALKLLASFCIVYERNGYEKVLRAITTIAATSFKASERFRPIVDALFASD 287
            .:.:|:..:..:|....|::|:|.|.|  :.|.|.|..|.... ...|:...||..::.  |.|.
 Worm   338 CIVRSILHQNLRTKTLVLQMLSSICWV--QGGQELVSDAFDRF-EKDFREPRRFWTLMQ--FVSH 397

  Fly   288 QQDPKRDLACHSLIFINTLTNTPTDLNFRLHLRCEIMRMGLYDRLDEFTKIVEASNNENLQQHFK 352
            ..:...:....::.|.....|. .|||||:||:.|:..:|                   |.::..
 Worm   398 PPEFHVEFLSSAVQFFYYFVNV-DDLNFRVHLQYEMTLLG-------------------LDKYID 442

  Fly   353 IFNEIREDDFEEFVQRFDNVTFNMDDATDCFDVLKNLVTDTTSEPYFLS----ILQHLLYIRDDF 413
            :..|...|:.:|.:..:.|         :..|| :.|:.|:..:...|.    ||..|...:
 Worm   443 MMAECESDELQERMISYQN---------NGIDV-QQLLDDSNQKTELLDENERILSQLSQAK--- 494

  Fly   414 YFRPAYYQLIEECISQIVFHKGYCDPNFENRNFNIDTSLLLDDIVEKAKAKESKRSEE------- 471
                   :.|:|..::.:..|...|..             |.|:|::.::.|.:..||
 Worm   495 -------ERIQEVEAKWITDKAALDRR-------------LFDLVKERESMEKEYVEEKGSWTKT 539

  Fly   472 YEKKIEQLESAKQEAEAKAAHLEEKVKLMEAN-----------GVAAPSPNKLPKVNIPMPPPPP 525
            ..:|..|....::..|.|...||...|.|:|.           ..||.:..|.|    |.||||.
 Worm   540 MNEKDRQAREERKRLEQKIGELEAIQKQMQAGLQVQQQQQAAAAAAAAAAQKSP----PTPPPPA 600

  Fly   526 GG--------------GGAPP-----PPPPPMPG-RAGGGP----PPPPPPPMPGRAGG--PPPP 564
            .|              ..|||     |||||:.| .|..|.    |||||||:|....|  ||||
 Worm   601 PGPHKEQRRSTSKDPPRPAPPPVSSIPPPPPIAGLLAANGTNVPIPPPPPPPLPQNLSGAPPPPP 665

  Fly   565 PPPPGMGGPPPPPMPGMMRPGGGPPPPPMMMGPMVPVLPHGLKP-KKKWDVKNPMKRANWKAIVP 628
            ||||.:||||||           ||||..:|||    ..:..|. ||.:..||.:.:.||.|:.|
 Worm   666 PPPPMLGGPPPP-----------PPPPGGLMGP----ASNDAKTIKKIYQTKNKLPQLNWTAMKP 715

  Fly   629 --------AKMSDKAFWVKCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDK----------PT 675
                    .|::|:....|....||.:...||:..:..:.   .|.::..:.:          .|
 Worm   716 MQAKNTVFEKLNDELIIEKLDFSKLEEMFKLAQPTLGLAE---PKSEQSVIGQVSPGSTTSAAGT 777

  Fly   676 TLTKKNVDLRVLDSKTAQNLAI------MLGGSLKHLSYEQIKICLLRCD-TDILSSNILQQLIQ 733
            :..:||.   :||:|..||:||      |...|:. .:..|:.:..|..: .||||        :
 Worm   778 SSARKNT---LLDTKRLQNVAITRRKVAMDAKSIM-AAVHQLNLSALSAEKVDILS--------R 830

  Fly   734 YLPPPEHL-----KRLQEIKAKGEPLPPIEQFAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPD 793
            .||..|..     |:..|.:...|.|...:.|.|.:.||:||..:|..:.....:.:....::|.
 Worm   831 ILPTDEERKLYAGKKTTESENSMENLSEDDNFVAALCEIERLEHKLAVMRVMSEFDESAGLLEPQ 895

  Fly   794 IVAGTAACEEIRNSKKFSKILELILLLGNYMNSGSKNEAAFGFEISYLTKLSNTK-DADNKQTLL 857
            ....|||.:..|.::.|..:||:||..||||||| |...|:||::|.|..|:..| .||...|||
 Worm   896 FTHVTAASKCAREAQLFHGVLEVILAFGNYMNSG-KRGGAYGFKLSSLDSLAILKAPADRSLTLL 959

  Fly   858 HYLADLVEKKFPDALNFYDDLSHVNKASRVNMDAIQKAMRQMNSAVKNLETDLQNNKVPQCDDDK 922
            |.:...:||..|....|.:.|..|:||:.|..|::|..|:::.:..|..|.: |..|...|
 Worm   960 HMIVAEIEKNLPHLKTFSEQLKFVDKATSVQWDSVQTDMKELAAGFKMAEKE-QELKGTDC---- 1019

  Fly   923 FSEVMGKFAEECRQQV-DVLGKMQLQMEKLYKDLSEYYAFDPSKYTMEEFFADIKTFKDAFQAAH 986
             .|.:..|....:|:: |:....||.... :||..|:|..:....:...||..:..|...:|...
 Worm  1020 -PEALSTFTASRKQKMADLEQAFQLAASS-FKDCCEFYGENEKSTSPTVFFQKLAHFVQNYQKCR 1082

  Fly   987 NDN-------VRVREELEKKRRLQEAREQSAREQQERQQR-----------KKAVVDMDAPQTQE 1033
            .:|       .|.:||.|::.|:...:..::.||.:....           |:....:|:.:...
 Worm  1083 GENEAKAALEKRRQEEAERRARVASTKSSASSEQDQLMMELAEKVGGMGIGKRPRGKIDSTRMDH 1147

  Fly  1034 GVMDSLLEALQ-TGSAFGQRNRQARRQRPAGAERRAQLSRSRSRTRVTN 1081
            |..:.|:..|: ||..  ..||:...:.|:.|.|.:.......:|||.:
 Worm  1148 GDFEKLMNGLKHTGGT--TPNRRKMSKSPSPAPRGSAPPPVAPKTRVVS 1194

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
dia	NP_001246113.1	Drf_GBD	66..248	CDD:461886	48/280 (17%)
		Drf_FH3	253..453	CDD:461885	37/203 (18%)
		FH2	608..983	CDD:396655	109/407 (27%)
frl-1	NP_497505.4	Drf_GBD	94..362	CDD:461886	51/288 (18%)
		Drf_FH3	366..561	CDD:461885	47/250 (19%)
		FH2	695..1079	CDD:396655	109/406 (27%)