DRSC/TRiP Functional Genomics Resources

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Protein Alignment dia and Fmn1

DIOPT Version :10

Sequence 1:NP_001246113.1 Gene:dia / 35340 FlyBaseID:FBgn0011202 Length:1098 Species:Drosophila melanogaster
Sequence 2:NP_034360.2 Gene:Fmn1 / 14260 MGIID:101815 Length:1466 Species:Mus musculus


Alignment Length:731 Identity:178/731 - (24%)
Similarity:286/731 - (39%) Gaps:178/731 - (24%)


- Green bases have known domain annotations that are detailed below.


  Fly   421 QLIEECISQIVFHKGYCDPN-FENRNFNIDTSLLLDDIVEKAKAKESKRSEEYEKK----IEQLE 480
            ::.:.|||.    ...|.|. |.|.....|....|...  .|::|.::.|:...||    :.||.
Mouse   784 EMRDVCIST----DDDCSPKAFRNVCIQTDRETFLKPC--DAESKATRSSQIVPKKLTISLTQLS 842

  Fly   481 SAK---------QEAEAKAAHLEEKVKLMEANGVAAPSPNKLPKVNIPMPPP-PPGGGGAPPPPP 535
            .:|         |..|..::..:.|:     :..|.|:|..||...||.||| |||.|..||.||
Mouse   843 PSKDSKDIHAPFQTREGTSSSSQHKI-----SPPAPPTPPPLPPPLIPPPPPLPPGLGPLPPAPP 902

  Fly   536 --------PPMPGRAGGGPPPPPPPPMPGRAGGPPPPPPPPGM---------GGPPPPPMPGMMR 583
                    ||.|      ||||||.|:|...|.||||||||.:         |||||||      
Mouse   903 IPPVCPVSPPPP------PPPPPPTPVPPSDGPPPPPPPPPPLPNVLALPNSGGPPPPP------ 955

  Fly   584 PGGGPPPPPMMMGPMVPVLPHGLK------PKK-KWDVKNPMKRANWKAI-VPAKMSDKA--FWV 638
                |||||.:..|..|.|..||.      |:| ..:...|||...|..| :..|..|.|  .|.
Mouse   956 ----PPPPPGLAPPPPPGLSFGLSSSSSQYPRKPAIEPSCPMKPLYWTRIQINDKSQDAAPTLWD 1016

  Fly   639 KCQEDKLAQDDFLAELAVKFSSKPVKKEQKDAVDKPTTLTKKNVDLRVLDSKTAQNLAIMLGGSL 703
            ..:|..:........|..|.:::..||...:|.:|...:.|   .:::||.|.:|.:.|::  |.
Mouse  1017 SLEEPHIRDTSEFEYLFSKDTTQQKKKPLSEAYEKKNKVKK---IIKLLDGKRSQTVGILI--SS 1076

  Fly   704 KHLSYEQIKICLLRCDTDILSSNILQQLIQYLPPPEHLKRL---------QEIKAKGEPLPPIEQ 759
            .||..:.|:..:...|..::....|..|.:.....:.|.::         :::|...:|    ||
Mouse  1077 LHLEMKDIQQAIFTVDDSVVDLETLAALYENRAQEDELTKIRKYYETSKEEDLKLLDKP----EQ 1137

  Fly   760 FAATIGEIKRLSPRLHNLNFKLTYADMVQDIKPDIVAGTAACEEIRNSKKFSKILELILLLGNYM 824
            |...:.:|...:.|...:.|:..:::.:..:...:...|.|.:.:.:.|....||.|||..||||
Mouse  1138 FLHELAQIPNFAERAQCIIFRAVFSEGITSLHRKVEIVTRASKGLLHMKSVKDILALILAFGNYM 1202

  Fly   825 NSGSKNEA-AFGFEISYLTKLSNTKDADNKQTLLHYLADLVEKKFPDALNFYDDLSHVNK----- 883
            |.|::... |.|:.:..|.||.:.|..||...|:.|    |.|.:   |.:||...|.::     
Mouse  1203 NGGNRTRGQADGYSLEILPKLKDVKSRDNGMNLVDY----VVKYY---LRYYDQCKHHDQEASCR 1260

  Fly   884 --------------------------------------------ASRVNMDAIQKAMRQMNSAVK 904
                                                        ||:|..:.:.|.:|::.   :
Mouse  1261 GKDLFSLYFHIAVHPQRKSGLELKQEAGTDKSVFPLPEPQDFFLASQVKFEDLLKDLRKLK---R 1322

  Fly   905 NLETDLQNNKVPQCDD----------DKFSEVMGKFAEECRQQVDVLGKMQLQMEKLYKDLSEYY 959
            .||...|..|: .|.:          ||..|...|..:|.:.:...|...|    |.::....|:
Mouse  1323 QLEASEQQMKL-VCKESPREYLQPFKDKLEEFFKKAKKEHKMEESHLENAQ----KSFETTVGYF 1382

  Fly   960 AFDPSKYTME-----------EFFADIKT-FKDAFQAAHNDNVRVRE----ELEKKRRLQEAREQ 1008
            ...|.....|           ||.:|.|| :|...:....:.:::.:    :|..:::::..:..
Mouse  1383 GMKPKTGEKEVTPSYVFMVWFEFCSDFKTIWKRESKNISKERLKMAQASVSKLTSEKKVETKKIN 1447

  Fly  1009 SAREQQERQQRKKAVV 1024
            .....:||.::|:|.|
Mouse  1448 PTASLKERLRQKEASV 1463

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
diaNP_001246113.1 Drf_GBD 66..248 CDD:461886
Drf_FH3 253..453 CDD:461885 8/32 (25%)
FH2 608..983 CDD:396655 97/459 (21%)
Fmn1NP_034360.2 Microtubule-binding 1..624
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 150..192
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 224..329
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 377..413
PHA03247 <449..706 CDD:223021
Mediates interaction with alpha-catenin 458..842 15/63 (24%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 507..534
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 559..598
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 681..713
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 840..897 20/61 (33%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 913..989 37/91 (41%)
FH2 984..1417 CDD:214697 96/456 (21%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1446..1466 5/18 (28%)
Blue background indicates that the domain is not in the aligned region.

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