DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Pyroxd1 and pyroxd1

DIOPT Version :9

Sequence 1:	NP_001260619.1	Gene:	Pyroxd1 / 35296	FlyBaseID:	FBgn0032846	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_957057.1	Gene:	pyroxd1 / 393736	ZFINID:	ZDB-GENE-040426-1732	Length:	490	Species:	Danio rerio

Alignment Length:	497	Identity:	236/497 - (47%)
Similarity:	312/497 - (62%)	Gaps:	43/497 - (8%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RKCEFLVVGGGIAGVSCAESLAIYRPNASILLLTESSIVKSVTNLVPVARYLHKFDVREQD---V 64
            ::.:|::||||||||:|||.:|...|:..:.|||.|.:||.|||...|::.|.:||:.||.   :
Zfish    10 KQVKFVIVGGGIAGVTCAEQIASQFPSDEVCLLTASPLVKKVTNFRQVSKTLEEFDIEEQPSRVL 74

  Fly    65 SEMGASFQTLVDRLDHINSREHCIRTKAGLEIKYRYLCLCTGGTPKLFSGKVVNPLVIGIRDTDS 129
            .|...:.:.|...:..:.:|||.:.|:.|....||.||||:||.|||.|..  ||.|:|||||||
Zfish    75 EEKYPNLKVLQSAVRLLKAREHLLETEDGQRFFYRKLCLCSGGRPKLLSKD--NPHVLGIRDTDS 137

  Fly   130 VQLLQRKLATAKDVLILGNGGIASELAYELKDVNVHWVVKDSHISATFVDPGAAEFFHIAMNECN 194
            .|..|::|:|||.::::||||||.||.||::...|.|.|||..|..||.|.|||:|. |...|.:
Zfish   138 AQEFQKRLSTAKRIVVIGNGGIALELVYEVEGCEVIWAVKDKAIGNTFFDAGAAQFL-IPSLEAD 201

  Fly   195 AKDSSPVVAIKRMRY----SEVLPKEQTNNHGAALGPDWHRSVDLSGAREGEENRLPKIYYKSRI 255
            .:::|.|  .||.||    |.......::..|:|||||||..::|.||::..  |...|.|:..:
Zfish   202 RREASSV--CKRARYTTDSSAAGHSGSSSELGSALGPDWHEGIELRGAKQSV--RGVHIEYECEV 262

  Fly   256 SSV---QDLADDAGAIVKLEHEDG----------SFQQLT------CDFIVSATGVWPNTD-YTC 300
            ..:   |:|         |:.|.|          ::.|||      ||||||||||.|||| :..
Zfish   263 EQIYTQQEL---------LQSEHGTKTAELGVWPAYVQLTNGKIYGCDFIVSATGVVPNTDPFLP 318

  Fly   301 DSPLQFSDDGGISVDEMMRTNLVDVFAAGDVCTANWPAAMHWFQMRLWTQARQMGSMAGRSMAAA 365
            .:....:.|.|:.||:.|||:..|||||||||:|.|..:..|.||||||||||||..|.|.|||.
Zfish   319 GNNFDVAADLGLLVDDHMRTSEADVFAAGDVCSAGWEPSSIWQQMRLWTQARQMGWYAARCMAAD 383

  Fly   366 SEGESVYQDFCFELFGHVTKLFGYPVVLLGRFNGQDLGRDYEILVRCTRNKEYIKFVLQNGRLRG 430
            ...|.:..|||||||.|:||.|.|.|||||:||.|.||:|:|:|||||:.:||:|.||..||:.|
Zfish   384 VLDEPIELDFCFELFSHITKFFNYKVVLLGKFNAQGLGQDHELLVRCTKGQEYVKVVLSGGRMVG 448

  Fly   431 AMLIGNTDLAETCENLILNGIDLEPYGDDILNPDIDIEDYFD 472
            |:|||.|||.||.||||||.:||..||:::|||:||||||||
Zfish   449 AVLIGETDLEETFENLILNQMDLTRYGEELLNPNIDIEDYFD 490

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pyroxd1	NP_001260619.1	Pyr_redox_2	8..355	CDD:285266	160/373 (43%)
pyroxd1	NP_957057.1	Pyr_redox_2	13..373	CDD:285266	161/375 (43%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580652
Domainoid	1	1.000	139	1.000	Domainoid score	I4768
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11758
Inparanoid	1	1.050	413	1.000	Inparanoid score	I1820
OMA	1	1.010	-	-		QHG55526
OrthoDB	1	1.010	-	-		D1463391at2759
OrthoFinder	1	1.000	-	-		FOG0006989
OrthoInspector	1	1.000	-	-		oto39353
orthoMCL	1	0.900	-	-		OOG6_106473
Panther	1	1.100	-	-	LDO	PTHR43429
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3689
SonicParanoid	1	1.000	-	-		X1984
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	15	14.940