DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Pyroxd1 and Pyroxd1

DIOPT Version :9

Sequence 1:	NP_001260619.1	Gene:	Pyroxd1 / 35296	FlyBaseID:	FBgn0032846	Length:	472	Species:	Drosophila melanogaster
Sequence 2:	NP_001004234.1	Gene:	Pyroxd1 / 297708	RGDID:	1303253	Length:	498	Species:	Rattus norvegicus

Alignment Length:	497	Identity:	237/497 - (47%)
Similarity:	310/497 - (62%)	Gaps:	39/497 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 FLVVGGGIAGVSCAESLAIYRPNASILLLTESSIVKSVTNLVPVARYLHKFDVREQDVSEMGASF 71
            |:|||||||||:|||.|||..|...|||:|.|.::|:|||...|::.|.:|||.||..:.:...|
  Rat    10 FVVVGGGIAGVTCAEQLAINFPAEDILLVTASPVIKAVTNFKQVSKVLEEFDVEEQPSTMLENRF 74

  Fly    72 ---QTLVDRLDHINSREHCIRTKAGLEIKYRYLCLCTGGTPKLF-SGKVVNPLVIGIRDTDSVQL 132
               :.:...:..:.|.:|||.|:.|.|..|:.||||.|..|||. .|   ||.|:|||||||.|.
  Rat    75 PNIKVIESGVKQLKSDKHCIFTEDGREYVYKKLCLCAGAKPKLICEG---NPYVLGIRDTDSAQE 136

  Fly   133 LQRKLATAKDVLILGNGGIASELAYELKDVNVHWVVKDSHISATFVDPGAAEFFHIAMNECNAKD 197
            .|::|..|:.::|:||||||.|||||::...|.|.:||..|..||.|.|||||.   .:...::.
  Rat   137 FQKQLTKARRIMIVGNGGIALELAYEVEVCEVIWAIKDKAIGNTFFDAGAAEFL---TSRLLSEK 198

  Fly   198 SSPVVAIKRMRYSEVLPKEQTNNH------GAALGPDWHRSVDLSGAREGEEN-------RLPKI 249
            |...:|.||..|:....|::|:..      |:|||||||..:.|.|..|...:       .:.||
  Rat   199 SEAKLAHKRTIYTVEEAKKETSTKSKADYVGSALGPDWHGGLALKGTEEFSHSIHIETKCEVKKI 263

  Fly   250 YYKS--RISSVQDLA---DDAGAI--------VKLEHEDGSFQQLTCDFIVSATGVWPNTD-YTC 300
            |.:.  :|...:.||   |...::        |.:|..:||.  ..|||:||||||.||.. :..
  Rat   264 YLQEEFKIMKKKSLAFPKDHHKSVTVDKEMWPVYVELTNGSI--YGCDFLVSATGVTPNVQPFLH 326

  Fly   301 DSPLQFSDDGGISVDEMMRTNLVDVFAAGDVCTANWPAAMHWFQMRLWTQARQMGSMAGRSMAAA 365
            .:.....:|||:.|||.|||:|.|::||||:|||.||.:..|.||||||||||||..|.:.||||
  Rat   327 GNDFDLGEDGGLRVDEQMRTSLPDIYAAGDICTACWPPSPVWQQMRLWTQARQMGCYAAKCMAAA 391

  Fly   366 SEGESVYQDFCFELFGHVTKLFGYPVVLLGRFNGQDLGRDYEILVRCTRNKEYIKFVLQNGRLRG 430
            :.|..:..||.||||.||||.|.|.|||||::|.|.||.|:|:::||||.:||||.|:.|||:.|
  Rat   392 TMGHPIDMDFSFELFAHVTKFFNYKVVLLGKYNAQGLGVDHELMLRCTRGQEYIKVVMHNGRMMG 456

  Fly   431 AMLIGNTDLAETCENLILNGIDLEPYGDDILNPDIDIEDYFD 472
            |:|||.|||.||.||||||.:||..||:|:||||||||||||
  Rat   457 AVLIGETDLEETFENLILNQMDLSSYGEDLLNPDIDIEDYFD 498

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Pyroxd1	NP_001260619.1	Pyr_redox_2	8..355	CDD:285266	160/377 (42%)
Pyroxd1	NP_001004234.1	Pyr_redox_2	<76..381	CDD:285266	137/332 (41%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166340811
Domainoid	1	1.000	162	1.000	Domainoid score	I3906
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11758
Inparanoid	1	1.050	416	1.000	Inparanoid score	I1767
OMA	1	1.010	-	-		QHG55526
OrthoDB	1	1.010	-	-		D1463391at2759
OrthoFinder	1	1.000	-	-		FOG0006989
OrthoInspector	1	1.000	-	-		oto98775
orthoMCL	1	0.900	-	-		OOG6_106473
Panther	1	1.100	-	-	LDO	PTHR43429
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X1984
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	16	15.770