Protein Alignment lok and DCLK3

DIOPT Version :10

• Sequence 1: NP_477219.1
• Gene: lok / 35288
• FlyBaseID: FBgn0019686
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_001381601.1
• Gene: DCLK3 / 85443
• HGNCID: 19005
• Length: 817
• Species: Homo sapiens
• Alignment Length: 290
• Identity: 105/290 - (36%)
• Similarity: 169/290 - (58%)
• Gaps: 24/290 - (8%)

  Fly   170 INKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIMKN 234
            :.|.|...|.:|.|.:.:|:......|.|.:||||:.|:.|.|..        |.|.:|..|:::
Human   521 VEKHYETGRVIGDGNFAVVKECRHRETRQAYAMKIIDKSRLKGKE--------DMVDSEILIIQS 577

  Fly   235 LSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDRGI 299
            ||||.:|::|::.:....:|::||:::||||.:.||.:....|..:.|....:|.|:.::||:.|
Human   578 LSHPNIVKLHEVYETDMEIYLILEYVQGGDLFDAIIESVKFPEPDAALMIMDLCKALVHMHDKSI 642

  Fly   300 THRDLKPDNVLLETN-DEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTKK 363
            .||||||:|:|::.| |:.|.||::||||:|.|.:.  :.|:||||.|||||:|   ..:.|..:
Human   643 VHRDLKPENLLVQRNEDKSTTLKLADFGLAKHVVRP--IFTVCGTPTYVAPEIL---SEKGYGLE 702

  Fly   364 VDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQ------IKKGRFAYGHPSWKSVSQRAKLLINQML 422
            ||:|:.||:|:..|.|..||.    :|...|      |:.|.|.:..|.|.::|..||.|::::|
Human   703 VDMWAAGVILYILLCGFPPFR----SPERDQDELFNIIQLGHFEFLPPYWDNISDAAKDLVSRLL 763

  Fly   423 IVDPERRPSIDDVLQSSWLRDAPMLQKAKR 452
            :|||::|.:...|||..|:..|......||
Human   764 VVDPKKRYTAHQVLQHPWIETAGKTNTVKR 793

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA_CHK2	32..158	CDD:438718
		STKc_Chk2	167..441	CDD:270986	101/277 (36%)
DCLK3	NP_001381601.1	DCX_DCLK3	93..177	CDD:340528
		STKc_DCKL3	524..781	CDD:271087	100/273 (37%)