Protein Alignment lok and CAMK4

DIOPT Version :10

• Sequence 1: NP_477219.1
• Gene: lok / 35288
• FlyBaseID: FBgn0019686
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_001735.1
• Gene: CAMK4 / 814
• HGNCID: 1464
• Length: 473
• Species: Homo sapiens
• Alignment Length: 300
• Identity: 100/300 - (33%)
• Similarity: 164/300 - (54%)
• Gaps: 20/300 - (6%)

  Fly   168 EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIM 232
            :.::..:.|..:||.||..:|.......|.:.:|:|::||.:           |...|..|..::
Human    40 DALSDFFEVESELGRGATSIVYRCKQKGTQKPYALKVLKKTV-----------DKKIVRTEIGVL 93

  Fly   233 KNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSEDISKLYFYQMCHAVKYLHDR 297
            ..||||.::::.:|.:.|..:.:|||.:.||:|.:||:.....||..:.....|:..||.|||:.
Human    94 LRLSHPNIIKLKEIFETPTEISLVLELVTGGELFDRIVEKGYYSERDAADAVKQILEAVAYLHEN 158

  Fly   298 GITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYTK 362
            ||.||||||:|:|..|...:..||::||||||.|:...:|:|:||||.|.|||:| .|.  ||..
Human   159 GIVHRDLKPENLLYATPAPDAPLKIADFGLSKIVEHQVLMKTVCGTPGYCAPEIL-RGC--AYGP 220

  Fly   363 KVDIWSLGVVLFTCLSGTLPFSDEYGTP-AAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDP 426
            :||:||:|::.:..|.|..||.||.|.. ..::|....:.:..|.|..||..||.|:.:::::||
Human   221 EVDMWSVGIITYILLCGFEPFYDERGDQFMFRRILNCEYYFISPWWDEVSLNAKDLVRKLIVLDP 285

  Fly   427 ERRPSIDDVLQSSWLRDAPMLQKAKRLMKLDGMEIEEENF 466
            ::|.:....||..|:..     ||...:.:|..:.:.:.|
Human   286 KKRLTTFQALQHPWVTG-----KAANFVHMDTAQKKLQEF 320

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA_CHK2	32..158	CDD:438718
		STKc_Chk2	167..441	CDD:270986	95/273 (35%)
CAMK4	NP_001735.1	STKc_CaMKIV	42..335	CDD:270987	99/297 (33%)
		Autoinhibitory domain	305..321		1/15 (7%)
		PP2A-binding	306..323		1/14 (7%)
		Calmodulin-binding. /evidence=ECO:0000255	322..341
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	341..368
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	445..473