Protein Alignment lok and Camk1

DIOPT Version :10

• Sequence 1: NP_477219.1
• Gene: lok / 35288
• FlyBaseID: FBgn0019686
• Length: 476
• Species: Drosophila melanogaster
• Sequence 2: NP_598687.1
• Gene: Camk1 / 52163
• MGIID: 1098535
• Length: 374
• Species: Mus musculus
• Alignment Length: 283
• Identity: 109/283 - (38%)
• Similarity: 157/283 - (55%)
• Gaps: 13/283 - (4%)

  Fly   168 EEINKTYYVNRKLGSGAYGLVRLVYDTRTCQQFAMKIVKKNMLSGARPSTNFSDPDRVLNEAKIM 232
            |:|...|.....||:||:..|.|..|.||.:..|:|.:.|..|.|...|..        ||..::
Mouse    14 EDIRDIYDFRDVLGTGAFSEVILAEDKRTQKLVAIKCIAKKALEGKEGSME--------NEIAVL 70

  Fly   233 KNLSHPCVVRMHDIVDKPDSVYMVLEFMRGGDLLNRIISNKLLSE-DISKLYFYQMCHAVKYLHD 296
            ..:.||.:|.:.||.:....:|::::.:.||:|.:||:.....:| |.|:|.| |:..|||||||
Mouse    71 HKIKHPNIVALDDIYESGGHLYLIMQLVSGGELFDRIVEKGFYTERDASRLIF-QVLDAVKYLHD 134

  Fly   297 RGITHRDLKPDNVLLETNDEETLLKVSDFGLSKFVQKDSVMRTLCGTPLYVAPEVLITGGREAYT 361
            .||.||||||:|:|..:.||::.:.:|||||||.....||:.|.||||.|||||||   .::.|:
Mouse   135 LGIVHRDLKPENLLYYSLDEDSKIMISDFGLSKMEDPGSVLSTACGTPGYVAPEVL---AQKPYS 196

  Fly   362 KKVDIWSLGVVLFTCLSGTLPFSDEYGTPAAQQIKKGRFAYGHPSWKSVSQRAKLLINQMLIVDP 426
            |.||.||:||:.:..|.|..||.||......:||.|..:.:..|.|..:|..||..|..::..||
Mouse   197 KAVDCWSIGVIAYILLCGYPPFYDENDAKLFEQILKAEYEFDSPYWDDISDSAKDFIRHLMEKDP 261

  Fly   427 ERRPSIDDVLQSSWLRDAPMLQK 449
            |:|.:.:..||..|:.....|.|
Mouse   262 EKRFTCEQALQHPWIAGDTALDK 284

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
lok	NP_477219.1	FHA_CHK2	32..158	CDD:438718
		STKc_Chk2	167..441	CDD:270986	106/273 (39%)
Camk1	NP_598687.1	STKc_CaMKI_alpha	16..278	CDD:271069	106/273 (39%)
		Autoinhibitory domain. /evidence=ECO:0000250	276..316		2/9 (22%)
		Calmodulin-binding. /evidence=ECO:0000250	296..317
		Nuclear export signal. /evidence=ECO:0000250	315..321