Protein Alignment CG10631 and Thap12

DIOPT Version :10

• Sequence 1: NP_609998.1
• Gene: CG10631 / 35262
• FlyBaseID: FBgn0032817
• Length: 3781
• Species: Drosophila melanogaster
• Sequence 2: NP_001178559.1
• Gene: Thap12 / 308845
• RGDID: 1309679
• Length: 757
• Species: Rattus norvegicus
• Alignment Length: 835
• Identity: 173/835 - (20%)
• Similarity: 270/835 - (32%)
• Gaps: 298/835 - (35%)

  Fly  1752 IPGFFTPTCALSHCRKRRSIDNDLRTYRYPRSEDLLEKWRANLRLA------PDQCRG--RICAD 1808
            :|.|    ||..:| .|:|..:||..:|:||.....:||..|.|.|      |||...  |:||.
  Rat     1 MPNF----CAAPNC-TRKSTQSDLAFFRFPRDPARCQKWVENCRRADLEDKTPDQLNKHYRLCAK 60

  Fly  1809 HFESQVRGKLK-----LKTGAVPT-------LNLGHDEGLIYDNEAIKVGMTEEEEGSSEMTRLK 1861
            |||:.:..:..     |:..|:||       ||..|..    ..:.||      |....|:..||
  Rat    61 HFETSMICRTSPYRTVLRDNAIPTIFDLTSHLNNPHSR----HRKRIK------ELSEDEIRTLK 115

  Fly  1862 PKR-ELIDEEEEELEAEEEPHEHDMYDEDEKDGHYFDPLELVETFAEHPSDDEAEY--------- 1916
            .|: |...|:|:|..:..:....::  .:::||:.. ||.|.|       .:..||
  Rat   116 QKKIEETSEQEQETNSNAQNPSAEV--GNQQDGNVL-PLTLEE-------KENKEYLKSLFEILI 170

  Fly  1917 ---------RGDEEDERDEDEDLDEAEHFHPDNPPTPPTIPLRREKPANNVTPICCLRHC----- 1967
                     .|.|.||..|.       .|.|||                    ...|..|
  Rat   171 LMGKQNIPLDGHEADEIPEG-------LFAPDN--------------------FQALLECRINSG 208

  Fly  1968 ------RKERTAFHLLSTFGFPKDRQLLLKWCANLHLNPDDCIGRVCI-----EHF-------QP 2014
                  |.|.||.:.|  |.....::.:|:.|       :.||....:     .||       ..
  Rat   209 EEVLRKRFETTAVNTL--FCSKTQQRQMLEIC-------ESCIREETLREVRDSHFFSIITDDVV 264

  Fly  2015 EVLGTRKLKQNAVPTL----NVGHDEPLRYSCNGM---DLDQEQLQPQH--SVFRLWSL--KHCR 2068
            ::.|...|     |.|    :..|:  ||....|.   :.|.|.|..:.  ::...|.|  ::||
  Rat   265 DIAGEEHL-----PVLVRFVDDAHN--LREEFVGFLPYEADAEILAVKFHTTITEKWGLNMEYCR 322

  Fly  2069 ------------------KRKLTEPP--------DIRQNKWSA----------------EVRKMQ 2091
                              .|.|.:.|        ....|.|.|                ||....
  Rat   323 GQAYIVSSGFSSKMKVVASRLLEKYPQAVYTLCSSCALNAWLAKSVPVIGVSVALGTIEEVCSFF 387

  Fly  2092 RLRMEMKMKIGREIKLEVQTEREMKSKEKTPTTSLGKIKLEICCINSCANDDVNQLL-------- 2148
            ....::.:::...|.:..|...|.           ||...|||........|..::|
  Rat   388 HRSPQLLLELDNVISVLFQNSEER-----------GKELKEICHSQWTGRHDAFEILVDLLQALV 441

  Fly  2149 ----QLPEDQNLLRKWQHNLK------LSVDTDFKEIQ--VCLKHFEEQVVQNGKPLE------- 2194
                .:..|.|:  :|.:.:.      .|..|||..|.  |.||:........||.|:
  Rat   442 LCLDGINSDTNI--RWNNYIAGRAFVLCSAVTDFDFIVTIVVLKNVLSFTRAFGKNLQGQTSDVF 504

  Fly  2195 --------------QAVPTLQLDQNSWNIYRNSGNCLFPECSNSSSDQLSFVDLPGNAVIRDAWM 2245
                          :.:..:::....|          |.|.:|.::.....:.|||.  .|.|..
  Rat   505 FAASSLTAVLHSLNEVMENIEVYHEFW----------FEEATNLATKLDIQMKLPGK--FRRAQQ 557

  Fly  2246 SHLNLPPSSEGLLCSEHFMQLFEQVEYPKV-LAAQDLEDL--QWIVDELRC--AVPS-------- 2297
            .:|      |..|.||.:.:  :.:..|.| ...|:|:|:  :..:..|:|  .|||
  Rat   558 GNL------ESQLTSESYYK--DALSVPTVEHIIQELKDIFSEQHLKALKCLSLVPSVMGQLKFN 614

  Fly  2298 CSSKSDGDLQLIPFPKKDATLLKWLQNTKISYDHLKHKSYRICVLHFEPTCLEA-------NFPK 2355
            .|.:...|:.....|..| ||...|...:|.:   ||:...|   ....|..||       .||.
  Rat   615 TSEEHHADMYRSDLPNPD-TLSAELHCWRIKW---KHRGKDI---ELPSTIYEALHLPDIKFFPN 672

  Fly  2356 AWA-------IPTLHLNHDDELHLNLRPESRSGTPNS-----NSRLTPLRIKTDL 2398
            .:|       :|.:.:  ::|.:.|.|...::...|:     :|.|..|.|..|:
  Rat   673 VYALLKVLCILPVMKV--ENERYENGRKRLKAYLRNTLTDQRSSNLALLNINFDI 725

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG10631	NP_609998.1	C2H2 Zn finger	288..311	CDD:275368
		C2H2 Zn finger	319..339	CDD:275368
		DM3	584..642	CDD:128933
		DM3	683..738	CDD:128933
		DM3	775..832	CDD:128933
		DM3	945..1000	CDD:128933
		DM3	1038..1096	CDD:128933
		DM3	1145..1198	CDD:128933
		THAP	1236..1308	CDD:214951
		DM3	1349..1406	CDD:128933
		THAP	1424..1493	CDD:214951
		DM3	1538..1596	CDD:128933
		DM3	1683..1739	CDD:128933
		DM3	1778..1831	CDD:128933	23/72 (32%)
		DM3	1980..2033	CDD:128933	11/68 (16%)
		DM3	2147..2202	CDD:128933	15/95 (16%)
		DM3	2308..2365	CDD:128933	16/70 (23%)
		DM3	2434..2491	CDD:128933
		DM3	2539..2598	CDD:128933
		DM3	2622..2680	CDD:128933
		DM3	2718..2775	CDD:128933
		DM3	2907..2965	CDD:128933
		DM3	3098..3155	CDD:128933
		DM3	3227..3284	CDD:128933
		DM3	3396..3452	CDD:128933
		DM3	3544..3601	CDD:128933
		THAP	3622..>3673	CDD:461662
		DM3	3690..3748	CDD:128933
Thap12	NP_001178559.1	THAP	5..86	CDD:461662	28/81 (35%)
		DUF4371	<153..326	CDD:480613	42/222 (19%)
		Dimer_Tnp_hAT	<668..725	CDD:399013	12/58 (21%)