DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG10462 and zf30C

DIOPT Version :9

Sequence 1:	NP_609996.2	Gene:	CG10462 / 35260	FlyBaseID:	FBgn0032815	Length:	812	Species:	Drosophila melanogaster
Sequence 2:	NP_477301.1	Gene:	zf30C / 34292	FlyBaseID:	FBgn0270924	Length:	777	Species:	Drosophila melanogaster

Alignment Length:	828	Identity:	181/828 - (21%)
Similarity:	290/828 - (35%)	Gaps:	243/828 - (29%)

- Green bases have known domain annotations that are detailed below.

  Fly    76 PK-HCDICQYKFKSQQDISSHRVHHEMNLHF-CRLGCGIWLDTLEKILEHEYRQHFQPGRV---- 134
            || ||.:|.....|......|...|:....| || .|.......|::.:|...:|...|.|
  Fly    29 PKLHCPVCNKALVSLAGYVKHVKKHQPPGGFECR-HCDARFCHEEELTQHAKDEHGVTGAVAGQE 92

  Fly   135 ---LCCRVCDFMANSADDLASHMQKHIYVYR-------------------FVCSICRRHFESKQS 177
               ..|..|     .|:      .|:...||                   ..|..|...|.|..:
  Fly    93 RKPFVCEKC-----GAE------YKYQEAYRRHCRTKCGEEKLPREESRPMECKCCYTRFSSASN 146

  Fly   178 LNLHRKQSQDFCSLLDFRKGSSS------------------------KPELVAVSTPVPEESNCY 218
            |:.||:...|.|...::....||                        ..|.......:|..|...
  Fly   147 LSKHRRSRPDTCGQPEYDSPGSSDGMKKHKAFRKKDRNRDSDDEDTTSEESEDSDDDIPLASRLK 211

  Fly   219 VQIKE--------------EPLNAE-EADRMLLEDNPPLNVKLEPQDE---EMPDVSRIKEEQSN 265
            .::|:              ||.|:| :||....:..||..||:|..||   |..|.|...:.:|
  Fly   212 TKLKQESQNSDSGDECPDFEPNNSEDDADASGFQLPPPAMVKVEAFDEEDFEYQDASMYVKTES- 275

  Fly   266 GSVWTAIHTPLRNKLRLPALATTKNQMHLKPGVKRNGLLTSNVESLNKKSNHSVISDDANIPISN 330
                |.|.:..::|| |..|....:  .|||           .|||..:....::.:.|.:|:..
  Fly   276 ----TDIFSNEKDKL-LDVLLNEGD--GLKP-----------FESLKVEQGAGILDEIAAVPLVE 322

  Fly   331 QEPSNSSIAANILKVLPSNCMVIKLPPNTKIFKTPGQAPAAPKDS-PTVTLSGTENSTNFIKIPK 394
            ....:         ||......::.||.      |.:....||:. |.|.....:.:.     |:
  Fly   323 VAEED---------VLELRGHQMEKPPG------PRKRGRPPKEKIPVVKRKYRKRNA-----PR 367

  Fly   395 TISISTVGSMGNPHASAKTVQPTQTHSRSSCFLVDSFNNSKSRPESMKIINEFRNQIRSIEKTLP 459
              |.|...|.|.|...||.                   :.|...|.:|:||:       :||:..
  Fly   368 --SPSPDDSSGTPKRVAKI-------------------SKKELKERLKMINK-------MEKSWK 404

  Fly   460 LPGTVLQSSKVTMDESTSSPMDAPKPVEL------MLNPSALM-VARELEIQYPLYRFMWTCPLC 517
            .|..|    |:         ....||.|.      .||.:.:. :.:::::...|...::.||:|
  Fly   405 CPHCV----KI---------YHIRKPYEKHLRDDHKLNEAEMKEIFKDVDVHAKLDEEVFKCPIC 456

  Fly   518 QRMF--EKH-------------------CAFRAHLTNKHDLTD------------EKCNVLKVVL 549
            .:::  ||.                   |........|...|:            |||:
  Fly   457 SKIYLVEKRLVTHMKVHGEDGKLTFKCPCYCNLFFATKEQATEHARAQHKELLYCEKCD------ 515

  Fly   550 MPSKILSQDSANAATQRVHVPLNPQTPVPPPELPNTVNLPLLLSKTSAPLTGQTSALSNVPVNKG 614
              ..:...||.....:..|....|::.          ...|:..|.....||:||...:|..:.|
  Fly   516 --KYMTGHDSLKNHERNFHSKKEPRSQ----------QRNLICDKCGKKFTGRTSLSDHVRSDCG 568

  Fly   615 LSPTSINIEKPKVSKKPKKNQSFQCTECLKVFTTFGALRIHKSIHTGELPYQCSYCDKRFRTPGQ 679
            ..|.                  :.|:.|.|..:|.|.|:.|..:|..:.||||..|.|.|:...|
  Fly   569 RLPL------------------YGCSVCGKHLSTAGILKTHMLLHKADTPYQCDKCGKTFKVKAQ 615

  Fly   680 VRVHHR-RHTGEKPFKCKICSLDFTHRETLISHLSRHIGMKRYKCYGCDKYFVVVSGLRAHRRLR 743
            .:.|.: |||..||:||.:|..::.:||:|::|::.|.|:||:.|..|.|.|..:|.|:|||::.
  Fly   616 YKSHLKTRHTDYKPYKCHLCPKEYPYRESLLTHMTVHTGIKRFLCNNCGKRFTCISNLQAHRKVH 680

  Fly   744 PDTCGKVKFTARAHGPRVRVIRGEVVFQYHPEHNGYLRSEDPLNILSQ 791
            .||||::...|:| ...:.|.||:::....||..  :..|:...:::|
  Fly   681 ADTCGQLPLNAKA-TQYMGVQRGKLLMGAKPEAG--MEYEETKTLIAQ 725

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10462	NP_609996.2	C2H2 Zn finger	137..157	CDD:275371	3/19 (16%)
		C2H2 Zn finger	165..186	CDD:275371	7/20 (35%)
		C2H2 Zn finger	639..659	CDD:275368	7/19 (37%)
		zf-H2C2_2	651..676	CDD:290200	10/24 (42%)
		C2H2 Zn finger	667..687	CDD:275368	6/20 (30%)
		zf-H2C2_2	680..704	CDD:290200	9/24 (38%)
		C2H2 Zn finger	695..715	CDD:275368	6/19 (32%)
		C2H2 Zn finger	723..742	CDD:275368	9/18 (50%)
zf30C	NP_477301.1	C2H2 Zn finger	33..53	CDD:275368	4/19 (21%)
		C2H2 Zn finger	61..82	CDD:275368	5/21 (24%)
		C2H2 Zn finger	98..117	CDD:275368	6/29 (21%)
		C2H2 Zn finger	134..152	CDD:275368	6/17 (35%)
		C2H2 Zn finger	511..532	CDD:275370	5/28 (18%)
		COG5048	<523..>672	CDD:227381	49/176 (28%)
		C2H2 Zn finger	546..566	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..595	CDD:275368	7/19 (37%)
		C2H2 Zn finger	603..624	CDD:275368	6/20 (30%)
		C2H2 Zn finger	632..652	CDD:275368	6/19 (32%)
		C2H2 Zn finger	660..680	CDD:275368	9/19 (47%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E33208_3BRQ6
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.900