Protein Alignment Hakai and CBLL1

DIOPT Version :10

• Sequence 1: NP_001260593.1
• Gene: Hakai / 35256
• FlyBaseID: FBgn0032812
• Length: 473
• Species: Drosophila melanogaster
• Sequence 2: XP_016868132.1
• Gene: CBLL1 / 79872
• HGNCID: 21225
• Length: 531
• Species: Homo sapiens
• Alignment Length: 486
• Identity: 131/486 - (26%)
• Similarity: 179/486 - (36%)
• Gaps: 155/486 - (31%)

  Fly    89 GALGAVAASGNMTPATQQPQVLQQVPPPVMSQTTISLSLARAV--DMEA-DISQLE------APT 144
            |:||.:.....:.......|..:..|.| .:|.||:...|:|.  |.|. |.::.|      ...
Human    55 GSLGGLDVRRRIPIKLISKQANKAKPAP-RTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGEL 118

  Fly   145 FTTLSRGPPEPMLRLKWNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCA---R 206
            |....|.|.    .|.|:.:::::|||...| :|.||:|..||.:||||||||||||..||   .
Human   119 FANQRRFPG----HLFWDFQINILGEKDDTP-VHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHE 178

  Fly   207 AEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRHV-APQP- 269
            .:..|.||.|:|.|.|:||...|::|||:.      ..||:|||||||||||||||||: |.:|
Human   179 KKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKPV 237

  Fly   270 ---------PPLQPQPQLSAMAEQPKMTDLGGVGLGLELHKQRKLSESSVPISVSASIASRPV-- 323
                     ||:.|.|     .|.|:..          :....|...|.:|......:...|:
Human   238 TRASLENVHPPIAPPP-----TEIPERF----------IMPPDKHHMSHIPPKQHIMMPPPPLQH 287

  Fly   324 -------------------LSRLPLTGGVGNIGSIGSIPPPGSAAAAQNAIH-GGHSTLTLANLT 368
                               ||..|              |||.|.:.....|. ..||.|....:.
Human   288 VPHEHYNQPHEDIRAPPAELSMAP--------------PPPRSVSQETFRISTRKHSNLITVPIQ 338

  Fly   369 RINNANAQEC-------------HQGKASL---HHTL-------------------------KKG 392
            ..:|:.|:|.             :||:..:   ||.:                         ..|
Human   339 DDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAG 403

  Fly   393 TPHQSESVADASYYSS-----------VLASFGSAAGNPGSGPP---GGGATAAAQPA---NPSG 440
            |||...|.|.....:|           ::|.......:|..|||   .||....|.|.   ||:.
Human   404 TPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNS 468

  Fly   441 -----------SHSAVGPGALIGGSTDAPTG 460
                       |.....||.:..|...||.|
Human   469 LPQFTEDQGTLSPPFTQPGGMSPGIWPAPRG 499

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Hakai	NP_001260593.1	RING-HC_HAKAI-like	178..229	CDD:438171	29/53 (55%)
		zf_Hakai	229..264	CDD:465753	21/34 (62%)
CBLL1	XP_016868132.1	RING-HC_HAKAI-like	147..201	CDD:438171	29/53 (55%)
		zf_Hakai	201..232	CDD:465753	23/36 (64%)