DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Hakai and CBLL1

DIOPT Version :9

Sequence 1:	NP_001260593.1	Gene:	Hakai / 35256	FlyBaseID:	FBgn0032812	Length:	473	Species:	Drosophila melanogaster
Sequence 2:	XP_016868132.1	Gene:	CBLL1 / 79872	HGNCID:	21225	Length:	531	Species:	Homo sapiens

Alignment Length:	486	Identity:	131/486 - (26%)
Similarity:	179/486 - (36%)	Gaps:	155/486 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    89 GALGAVAASGNMTPATQQPQVLQQVPPPVMSQTTISLSLARAV--DMEA-DISQLE------APT 144
            |:||.:.....:.......|..:..|.| .:|.||:...|:|.  |.|. |.::.|      ...
Human    55 GSLGGLDVRRRIPIKLISKQANKAKPAP-RTQRTINRMPAKAPPGDEEGFDYNEEERYDCKGGEL 118

  Fly   145 FTTLSRGPPEPMLRLKWNHKVSLIGEKVLNPMIHCCDQCDKPILVYGRMIPCKHVFCLKCA---R 206
            |....|.|.    .|.|:.:::::|||...| :|.||:|..||.:||||||||||||..||   .
Human   119 FANQRRFPG----HLFWDFQINILGEKDDTP-VHFCDKCGLPIKIYGRMIPCKHVFCYDCAILHE 178

  Fly   207 AEPIKSCPRCTDKVLRVEQSGLGTVFMCTHGGSRYGSSGCRRTYLSQRDLQAHINHRHV-APQP- 269
            .:..|.||.|:|.|.|:||...|::|||:.      ..||:|||||||||||||||||: |.:|
Human   179 KKGDKMCPGCSDPVQRIEQCTRGSLFMCSI------VQGCKRTYLSQRDLQAHINHRHMRAGKPV 237

  Fly   270 ---------PPLQPQPQLSAMAEQPKMTDLGGVGLGLELHKQRKLSESSVPISVSASIASRPV-- 323
                     ||:.|.|     .|.|:..          :....|...|.:|......:...|:
Human   238 TRASLENVHPPIAPPP-----TEIPERF----------IMPPDKHHMSHIPPKQHIMMPPPPLQH 287

  Fly   324 -------------------LSRLPLTGGVGNIGSIGSIPPPGSAAAAQNAIH-GGHSTLTLANLT 368
                               ||..|              |||.|.:.....|. ..||.|....:.
Human   288 VPHEHYNQPHEDIRAPPAELSMAP--------------PPPRSVSQETFRISTRKHSNLITVPIQ 338

  Fly   369 RINNANAQEC-------------HQGKASL---HHTL-------------------------KKG 392
            ..:|:.|:|.             :||:..:   ||.:                         ..|
Human   339 DDSNSGAREPPPPAPAPAHHHPEYQGQPVVSHPHHIMPPQQHYAPPPPPPPPISHPMPHPPQAAG 403

  Fly   393 TPHQSESVADASYYSS-----------VLASFGSAAGNPGSGPP---GGGATAAAQPA---NPSG 440
            |||...|.|.....:|           ::|.......:|..|||   .||....|.|.   ||:.
Human   404 TPHLVYSQAPPPPMTSAPPPITPPPGHIIAQMPPYMNHPPPGPPPPQHGGPPVTAPPPHHYNPNS 468

  Fly   441 -----------SHSAVGPGALIGGSTDAPTG 460
                       |.....||.:..|...||.|
Human   469 LPQFTEDQGTLSPPFTQPGGMSPGIWPAPRG 499

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Hakai	NP_001260593.1	RING-HC_HAKAI_like	178..216	CDD:319422	23/40 (58%)
Hakai	NP_001260593.1	RING-HC finger (C3HC4-type)	180..216	CDD:319422	22/38 (58%)
CBLL1	XP_016868132.1	zf-C3HC4_2	149..188	CDD:290634	22/38 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165144570
Domainoid	1	1.000	50	1.000	Domainoid score	I11690
eggNOG	1	0.900	-	-		E1_KOG2932
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S6974
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005494
OrthoInspector	1	1.000	-	-		otm42225
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR13480
Phylome	0	0.000	Not matched by this tool.
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R5466
SonicParanoid	1	1.000	-	-		X3911
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	10	9.870