DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment swm and Rbm26

DIOPT Version :9

Sequence 1:	NP_001260586.1	Gene:	swm / 35235	FlyBaseID:	FBgn0002044	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	XP_030103918.1	Gene:	Rbm26 / 74213	MGIID:	1921463	Length:	1225	Species:	Mus musculus

Alignment Length:	1195	Identity:	344/1195 - (28%)
Similarity:	509/1195 - (42%)	Gaps:	309/1195 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFV 65
            ||:||.:.||.|||..|||:||||.||||:||:||:|||||:|:||.:.|:||||||.:||..||
Mouse   208 MIIENFEALKSWLSKTLEPICDADPSALAKYVLALVKKDKSEKELKALCIDQLDVFLQKETQIFV 272

  Fly    66 ERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNV 130
            |:||||:.::.||..|..|       |:..|.||     .:...:.||:            |:.:
Mouse   273 EKLFDAVNTKSYLPPPEQP-------SSGSLKVD-----FLQHQEKDIK------------KEEL 313

  Fly   131 IKPDSNQVKLEQASQDAREAEALAFISQEAGIAMHVPTDAKPAFDQHKTKDSHNQQSASNYQHHH 195
            .|.:..:.|..:...                   |.|..:...:..::::|...:...|..:.:
Mouse   314 TKEEEREKKFSRRLN-------------------HSPPQSSSRYRDNRSRDERKKDDRSRKRDY- 358

  Fly   196 VRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERAFRRS 260
              ..:||.|.|                  |.|:.|      |||...||.|||||||..:...|.
Mouse   359 --DRNPPRRDS------------------YRDRYN------RRRGRSRSYSRSRSRSWSKERLRD 397

  Fly   261 RSRDR-RVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADD---------------- 308
            |.||| |...|.:|:.:.|:...|....|.......|:.......|...
Mouse   398 RDRDRSRTRSRSRTRSRERDLVKPKYDLDRTDPLENNYTPVSSVSNISSGHYPVPTLSSTITVIA 462

  Fly   309 RPRFGNNKSRRSHSRSMSPERNARRNQNSPDRVQTAQANLIPAPVAPPAPVEHPASHPRQRCRDF 373
            ....|||.     :.|.|.....:.:.||              .|.||.        |::||||:
Mouse   463 PTHHGNNT-----TESWSEFHEDQVDHNS--------------YVRPPM--------PKKRCRDY 500

  Fly   374 DEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDAPEIWARSGGPPPGAGQGPVPPPT 438
            ||||:|:||:.||:|||.:|||.|.:|    :..|..:....|.:   .|.||||.   |.|||
Mouse   501 DEKGFCMRGDMCPFDHGSDPVVVEDVN----LPGMLPFPAQPPVV---EGPPPPGL---PPPPP- 554

  Fly   439 QPGQTTINPFSGNVRPTTLMSGSGPSPMGVPNPAD---YA-----RNPGAPP-QAAMMPFPFN-- 492
                 .:.|...|:||.  :...||.|..:|...|   |:     ..|..|| |.:.|..|.|
Mouse   555 -----ILTPPPVNLRPP--VPPPGPLPPSLPPVTDDISYSLVLTGPPPPLPPLQPSGMDAPPNSA 612

  Fly   493 ----PTAVTTPLQRQLIPIPV--------------VDG----AP--TGGVAEVGKRRFELED--- 530
                ||.|||.:..|..|.|.              .||    ||  |.....:.:.|...:.
Mouse   613 TSSVPTVVTTGIHHQPPPAPPSLFTAVFVLPDTYDTDGYNPEAPSITNTSRPMYRHRVHAQRPNL 677

  Fly   531 ---TVAIADVPTKRKVPINSRL----------------------------GPRVN----PNMQQ- 559
               |....|:|.:.|.|..|.:                            .|..|    |..|:
Mouse   678 IGLTSGDMDLPPREKPPNKSSMRIVVDSESRKRTIGSGEPGVSTKKTWFDKPNFNRTNSPGFQKK 742

  Fly   560 -----HNSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYEGDPEAAIVTFSTHAEANVAYRS 619
                 .|:.|||||||..||.|:.||.||::||.:||:||:|.||||.|::.|:|:.||..|..|
Mouse   743 VQFGNENTKLELRKVPPELNNISKLNEHFSRFGTLVNLQVAYNGDPEGALIQFATYEEAKKAISS 807

  Fly   620 TEAVLNNRFIKVFWHNDSSGADVGQMNQMGGGGGGGGR-----------KNASQYHLHNVPAVPT 673
            ||||||||||||:||.:      |...|:........:           |.:.:..|..||:..|
Mouse   808 TEAVLNNRFIKVYWHRE------GTTQQLQTTSPKVIQPLVQQPILPVVKQSVKERLGPVPSATT 866

  Fly   674 PNADGAKISNANP--LTEAGA----GNIGTP---ATEQANTAA---------PASMRLKLNTTTA 720
            ..|:....::..|  :|:...    |.:..|   |||:..:.:         ||:::....|.:.
Mouse   867 EPAEAQSATSELPQNVTKLSVKDRLGFVSKPSVSATEKVLSTSTGLTKTVYNPAALKAAQKTLSV 931

  Fly   721 GGSAGGAAGAGAPGSGRPLNPAANAASIRKKQEEQQKAVHQLANGLRKRKQELLQSYMKQMKTAL 785
            .                  .||.:....:||::|..|    |...:||||||:|:.:::..|..:
Mouse   932 S------------------TPAVDNNEAQKKKQEALK----LQQDVRKRKQEILEKHIETQKMLI 974

  Fly   786 ELVER---MDQQDPQRAPTLQTIKVLQMTIDKLRKEIKADQDQLQAQMQQQQQQQQPPVKKTKEQ 847
            ..:|:   |..:|  :|..::|:::|...|.||:.|:|:          ....:..|...|||.|
Mouse   975 SKLEKNKTMKSED--KAEIMKTLEILTKNITKLKDEVKS----------TSPGRCLPKSIKTKTQ 1027

  Fly   848 QKKELLDMELELIAQQQEGNDTTAIQKRLEELQ---RNLGVGSAANNKSTHYAPASGAPGGGAGR 909
            .:|||||.||:|..:.|.|.:.|.::::..|||   ...|:.|:...:..|......|.|.|.||
Mouse  1028 MQKELLDTELDLYKKMQAGEEVTELRRKYTELQLEAAKRGILSSGRGRGIHTRGRGTAHGRGRGR 1092

  Fly   910 KRPNLPEGPTRVDRRPKAIVVTGFAAEEADFVLGHFKNFGEISKHDVDREIPQLILSYATRLNAE 974
            .|.....|...||.||:|:.::.|...:.:.:|.||..:|||....:|......|:::.||..||
Mouse  1093 GRGRGVPGHAVVDHRPRALEISAFTESDREDLLPHFAQYGEIEDCQIDDASLHAIITFKTRAEAE 1157

  Fly   975 QAVLRGKMYKDKRLQISW-APVVTPAPAPMAAPVEKSAAPGDMSVSLENPKQLIQSVSESESLLG 1038
            .|.:.|..:|.:.|:::| .|:     |.|:|...:.|.|.:...             :.|||:.
Mouse  1158 AAAIHGARFKGQDLKLAWNKPI-----ANMSAVDTEEAEPDEEEF-------------QEESLVD 1204

  Fly  1039 SDTLPELRLEDEEEDEESEDRSWRR 1063
            ...|.    :|:||:|::|.|||||
Mouse  1205 DSLLQ----DDDEEEEDNESRSWRR 1225

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
swm	NP_001260586.1	RRM1_RBM26_like	561..634	CDD:240703	45/72 (63%)
swm	NP_001260586.1	RRM2_RBM26_like	921..992	CDD:240704	22/70 (31%)
Rbm26	XP_030103918.1	PWI	214..277	CDD:383025	41/62 (66%)
		ZnF_C3H1	<497..517	CDD:214632	13/19 (68%)
		RRM1_RBM26	749..824	CDD:240960	47/74 (64%)
		Mplasa_alph_rch	<938..>1059	CDD:275316	40/136 (29%)
		RRM2_RBM26_like	1104..1175	CDD:240704	22/70 (31%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167836960
Domainoid	1	1.000	227	1.000	Domainoid score	I2494
eggNOG	1	0.900	-	-		E1_KOG2135
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	374	1.000	Inparanoid score	I2077
Isobase	1	0.950	-	0	Normalized mean entropy	S7344
OMA	1	1.010	-	-		QHG48662
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0002919
OrthoInspector	1	1.000	-	-		otm44340
orthoMCL	1	0.900	-	-		OOG6_106329
Panther	1	1.100	-	-	O	PTHR14398
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R3653
SonicParanoid	1	1.000	-	-		X1927
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	15	14.740