Protein Alignment swm and RBM26

DIOPT Version :10

• Sequence 1: NP_001260586.1
• Gene: swm / 35235
• FlyBaseID: FBgn0002044
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: XP_011533481.1
• Gene: RBM26 / 64062
• HGNCID: 20327
• Length: 1025
• Species: Homo sapiens
• Alignment Length: 1152
• Identity: 329/1152 - (28%)
• Similarity: 482/1152 - (41%)
• Gaps: 312/1152 - (27%)

  Fly     1 MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFV 65
            ||:||.:.||.|||..|||:||||.||||:||:||:|||||:|:||.:.|:||||||.:||..||
Human     5 MIIENFEALKSWLSKTLEPICDADPSALAKYVLALVKKDKSEKELKALCIDQLDVFLQKETQIFV 69

  Fly    66 ERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNV 130
            |:||||:.::.||..|..|   :|.:...|....||         .||:            |:.:
Human    70 EKLFDAVNTKSYLPPPEQP---SSGSLKVEFFPHQE---------KDIK------------KEEI 110

  Fly   131 IKPDSNQVKLEQASQDAREAEALAFISQEAGIAMHVPTDAKPAFDQHKTKDSHNQQSASNYQHHH 195
            .|.:..:.|..:...                   |.|..:...:.:::::|...:...|..:.:
Human   111 TKEEEREKKFSRRLN-------------------HSPPQSSSRYRENRSRDERKKDDRSRKRDY- 155

  Fly   196 VRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERAFRRS 260
              ..:||.|.|                  |.|:.|      |||...||.|||||||..:...|.
Human   156 --DRNPPRRDS------------------YRDRYN------RRRGRSRSYSRSRSRSWSKERLRE 194

  Fly   261 RSRDRRVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSHSRSM 325
            |.|||                   |:|                               ||.||:.
Human   195 RDRDR-------------------SRT-------------------------------RSRSRTR 209

  Fly   326 SPERNARRNQNSPDRVQTAQANLIPAPVAP-------PAP-------VEHPASH----------- 365
            |.||:..:.:...||....:.|..|....|       |.|       |..|..|
Human   210 SRERDLVKPKYDLDRTDPLENNYTPVSSVPSISSGHYPVPTLSSTITVIAPTHHGNNTTESWSEF 274

  Fly   366 ---------------PRQRCRDFDEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDA 415
                           |::||||:||||:|:||:.||:|||.:|||.|.:|    :..|..:....
Human   275 HEDQVDHNSYVRPPMPKKRCRDYDEKGFCMRGDMCPFDHGSDPVVVEDVN----LPGMLPFPAQP 335

  Fly   416 PEIWARSGGPPPGAGQGPVPPPTQPGQTTINPFSGNVRPTTLMSGSGPSPMGVPNPAD---YA-- 475
            |.:   .|.||||.   |.|||      .:.|...|:||.  :...||.|..:|...|   |:
Human   336 PVV---EGPPPPGL---PPPPP------ILTPPPVNLRPP--VPPPGPLPPSLPPVTDDISYSLV 386

  Fly   476 ---RNPGAPP-QAAMMPFPFN------PTAVTTPLQRQLIPIPV--------------VDG---- 512
               ..|..|| |.:.|..|.|      ||.|||.:..|..|.|.              .||
Human   387 LTGPPPPLPPLQPSGMDAPPNSATSSVPTVVTTGIHHQPPPAPPSLFTAVFVLPDTYDTDGYNPE 451

  Fly   513 AP--TGGVAEVGKRRFELED------TVAIADVPTKRKVPINSRL-------------------- 549
            ||  |.....:.:.|...:.      |....|:|.:.|.|..|.:
Human   452 APSITNTSRPMYRHRVHAQRPNLIGLTSGDMDLPPREKPPNKSSMRIVVDSESRKRTIGSGEPGV 516

  Fly   550 --------GPRVN----PNMQQ------HNSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSY 596
                    .|..|    |..|:      .|:.|||||||..||.|:.||.||::||.:||:||:|
Human   517 PTKKTWFDKPNFNRTNSPGFQKKVQFGNENTKLELRKVPPELNNISKLNEHFSRFGTLVNLQVAY 581

  Fly   597 EGDPEAAIVTFSTHAEANVAYRSTEAVLNNRFIKVFWHNDSSGADVGQMNQMGGGGGGGGRKNAS 661
            .||||.|::.|:|:.||..|..|||||||||||||:||.:      |...|:         :..|
Human   582 NGDPEGALIQFATYEEAKKAISSTEAVLNNRFIKVYWHRE------GSTQQL---------QTTS 631

  Fly   662 QYHLHNVPAVPTPNADGAKISNANPLTEAGAGNIGTPATEQANTAAPASM-------RL------ 713
            ...:.  |.|..|.....|.|....|....:..|.....:.|::..|.::       ||
Human   632 PKVMQ--PLVQQPILPVVKQSVKERLGPVPSSTIEPAEAQSASSDLPQNVTKLSVKDRLGFVSKP 694

  Fly   714 ------KLNTTTAGGSAGGAAGAGAPGSGRPLNPAANAASIRKKQEEQQKAVHQLANGLRKRKQE 772
                  |:.:|:.|.:......|....:.:.|..:.:|....:.|:::|:|: :|...:||||||
Human   695 SVSATEKVLSTSTGLTKTVYNPAALKAAQKTLLVSTSAVDNNEAQKKKQEAL-KLQQDVRKRKQE 758

  Fly   773 LLQSYMKQMKTALELVER---MDQQDPQRAPTLQTIKVLQMTIDKLRKEIKADQDQLQAQMQQQQ 834
            :|:.:::..|..:..:|:   |..:|  :|..::|::||...|.||:.|:||          ...
Human   759 ILEKHIETQKMLISKLEKNKTMKSED--KAEIMKTLEVLTKNITKLKDEVKA----------ASP 811

  Fly   835 QQQQPPVKKTKEQQKKELLDMELELIAQQQEGNDTTAIQKRLEELQ---RNLGVGSAANNKSTHY 896
            .:..|...|||.|.:|||||.||:|..:.|.|.:.|.::::..|||   ...|:.|:...:..|.
Human   812 GRCLPKSIKTKTQMQKELLDTELDLYKKMQAGEEVTELRRKYTELQLEAAKRGILSSGRGRGIHS 876

  Fly   897 APASGAPGGGAGRKRPNLPEGPTRVDRRPKAIVVTGFAAEEADFVLGHFKNFGEISKHDVDREIP 961
            .......|.|.||.|.....|...||.||:|:.::.|...:.:.:|.||..:|||....:|....
Human   877 RGRGAVHGRGRGRGRGRGVPGHAVVDHRPRALEISAFTESDREDLLPHFAQYGEIEDCQIDDSSL 941

  Fly   962 QLILSYATRLNAEQAVLRGKMYKDKRLQISWAPVVTPAPAPMAAPVE 1008
            ..::::.||..||.|.:.|..:|.:.|:::|...||...|.....||
Human   942 HAVITFKTRAEAEAAAVHGARFKGQDLKLAWNKPVTNISAVETEEVE 988

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
swm	NP_001260586.1	RRM1_RBM26_like	561..634	CDD:409702	45/72 (63%)
		RRM2_RBM26_like	921..992	CDD:409703	21/70 (30%)
RBM26	XP_011533481.1	PWI	11..76	CDD:460224	43/64 (67%)
		ZnF_C3H1	<294..314	CDD:214632	13/19 (68%)
		RRM1_RBM26	546..621	CDD:409938	47/74 (64%)
		DR0291	717..>809	CDD:441187	28/104 (27%)
		RRM2_RBM26_like	901..972	CDD:409703	21/70 (30%)