DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment swm and rbm26

DIOPT Version :9

Sequence 1:	NP_001260586.1	Gene:	swm / 35235	FlyBaseID:	FBgn0002044	Length:	1063	Species:	Drosophila melanogaster
Sequence 2:	XP_002662309.4	Gene:	rbm26 / 619195	ZFINID:	ZDB-GENE-050706-50	Length:	1007	Species:	Danio rerio

Alignment Length:	1210	Identity:	344/1210 - (28%)
Similarity:	511/1210 - (42%)	Gaps:	350/1210 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFV 65
            ||:||.:.||.|||..|||:||||.||||:||:||:|||||:|:||.:.|:||||||.:||..||
Zfish     1 MIIENLEALKTWLSKTLEPICDADPSALAKYVVALVKKDKSEKELKALCIDQLDVFLQKETQTFV 65

  Fly    66 ERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNV 130
            ::||:|:.::.||..|..| ..||...|.:.|...|                 |....||.:|
Zfish    66 DKLFEAVNAKSYLPQPEQP-TPASRPETHQRTEKDE-----------------AKREEPPSRD-- 110

  Fly   131 IKPDSNQVKLEQASQDAREAEALAFISQEAGIAMHVPTDAKPAFDQHKTKDSHNQQSASNYQHHH 195
                           :.||.:....|:.....:.....|::...|:.|...|..::...|
Zfish   111 ---------------EDREKKFSRRINHSPPSSSRYSRDSRRVDDRKKDDRSRKREYDRN----- 155

  Fly   196 VRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERAFRRS 260
                 ||.|.|                  |.::.|:    ||.|:...|||||||.|.:|...|.
Zfish   156 -----PPRRDS------------------YRERYNR----RRERSRSYSRSRSRSWSKDRTRDRD 193

  Fly   261 RSRDRRVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSHSRSM 325
            |.|||   :|::::.:.|.:|...|::..|..|:..::                      |||
Zfish   194 RERDR---DRDRSRSRSRTRSRSRSRSRERDSGKPKYE----------------------HSR-- 231

  Fly   326 SPERNARRNQNSPDRVQTAQANLIPAP----------------VAPPAPVEH-----------PA 363
             |||        |:...|......|.|                :...||..|           |.
Zfish   232 -PER--------PEGATTDGYTAAPLPPVNSSAHFPVPTLSSTITVIAPTHHGNNTTESWSEFPQ 287

  Fly   364 SH--------PRQRCRDFDEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDAPEIWA 420
            .|        ||:||||:||||:|:||:.||:|||.:|||.|.:|..|::    .:.|  |.:..
Zfish   288 DHTPFGRGGPPRKRCRDYDEKGFCMRGDMCPFDHGSDPVVVEDVNLPSIL----PFQP--PPLPG 346

  Fly   421 RSGGPPPGAG------------QGPVPPP-TQPGQTTINPFSG---------------------N 451
            ..|.||||..            :.||||| |.|  .::.|.:|                     :
Zfish   347 VDGPPPPGLPPPHALLTPPVNLRPPVPPPGTMP--PSLPPVAGPPPPLPALQPSGMDGPPNSITS 409

  Fly   452 VRPTTLMSGSGPSPMGVPNPADYARNPGAP----PQAAMMPFPFNPTAVTTPLQR--------QL 504
            ..||.:.||..| ||..|.|..:..:|..|    |:|        |:..:.|:.|        .|
Zfish   410 SVPTIVTSGIRP-PMTQPPPPLFTSDPFEPDVYNPEA--------PSMTSRPMYRHRVNAQRPNL 465

  Fly   505 IPIPV--VDGAPTGGVAEVGKRRFELEDT-----VAIADVPTKRKVPINSRLGPRVN-PNMQQH- 560
            |.:.:  :|..|...::.....|..||..     ..:.|:....|.|...:  |..| ||  .|
Zfish   466 IGLTMAEMDLPPREKMSNSNNARIVLESDSRKRGAGLHDLAIPPKKPWFDK--PNFNKPN--HHG 526

  Fly   561 ----------NSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYEGDPEAAIVTFSTHAEANV 615
                      |:.|.:.::|..||.|:.||.||:|||.|||:||:|..|||.|::.|:|..||..
Zfish   527 FHRKVPFPLANTKLAIGQIPPELNNISKLNQHFSKFGTIVNLQVAYNNDPEGALIQFATPEEARR 591

  Fly   616 AYRSTEAVLNNRFIKVFWHNDSSGADVGQMNQMGGGGGGGGRKNASQYHLH----------NVPA 670
            |.:|||||||||||:|.||.:.                       :..|:|          ..||
Zfish   592 AIQSTEAVLNNRFIRVNWHRED-----------------------TVEHMHPKPHPSVQPAQEPA 633

  Fly   671 V--------------PTPNADGAKISNANPLTEAGAGNIGTPATEQANTAAPASMRLKLNTTTAG 721
            |              |||:.:.....:..|     ...:.....|:...:.|..:..|:.:|:.|
Zfish   634 VTALKQSVKDRLGPLPTPHPEPTPAPSGPP-----QNTLKASVKERLGFSKPPGLGTKVLSTSTG 693

  Fly   722 --GSAGGAAGAGAPGSGRPLNPAANAASIRKKQEEQQKAVHQLANGLRKRKQELLQSYMKQMKTA 784
              .:....|...|...|.|.:.:.:|....|:::|..|    |...:||:|||:|:.:::..|..
Zfish   694 LTKTVYNPAALKAGQKGAPFSASVSAEDALKRKQEAMK----LQQDVRKKKQEILEKHIQTQKLL 754

  Fly   785 LELVER---MDQQDPQRAPTLQTIKVLQMTIDKLRKEIK--ADQDQLQAQMQQQQQQQQPPVKKT 844
            :..:|:   |..:|  :|..:||:..|..:|.||::|||  :..:.|:..:            |:
Zfish   755 ISRLEKNKSMKAED--KAQIMQTLTSLTNSITKLQEEIKGLSSANALRTTV------------KS 805

  Fly   845 KEQQKKELLDMELELIAQQQEGNDTTAI-----QKRLEELQRNL-----GVGSAANNKSTHYAPA 899
            |.|.:|||||.||:|..:.|.|.||..:     |.:||..:|.|     |.|:.:..:....:..
Zfish   806 KAQAQKELLDTELDLYKKMQAGEDTAELKIKYTQLQLEAAKRGLLTPGRGRGAHSRGRGALRSRG 870

  Fly   900 SGAPGGGAGRKRPNLPEGPTR--VDRRPKAIVVTGFAAEEADFV--LGHFKNFGEISKHDVDREI 960
            .|..|.|.|        .||.  ||.||:|:.::||:  |||.|  |.||..:|||....::...
Zfish   871 RGIRGRGRG--------APTHAVVDHRPRALEISGFS--EADRVDLLPHFAQYGEIEDCQMEDSS 925

  Fly   961 PQLILSYATRLNAEQAVLRGKMYKDKRLQISW-APVVT-PAPAPMAAPVEKSAAPGDMSVSLENP 1023
            ...|::|.||..||||.:.|....::.|:::| .|..: ....|..|..|....|.|..|
Zfish   926 LSAIITYKTRAEAEQAAIHGVRLNNQELRLAWHKPTASLNTTDPDEAEAEDEEFPEDSLV----- 985

  Fly  1024 KQLIQSVSESESLLGSDTLPELRLEDEEEDEESEDRSWRR 1063
                     .:|||         .:|:||:|::|.|||||
Zfish   986 ---------DDSLL---------QDDDEEEEDNESRSWRR 1007

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
swm	NP_001260586.1	RRM1_RBM26_like	561..634	CDD:240703	40/72 (56%)
swm	NP_001260586.1	RRM2_RBM26_like	921..992	CDD:240704	27/72 (38%)
rbm26	XP_002662309.4	PWI	7..72	CDD:295364	41/64 (64%)
		ZnF_C3H1	<302..322	CDD:214632	13/19 (68%)
		RRM	453..740	CDD:223796	83/322 (26%)
		RRM_SF	537..612	CDD:302621	42/74 (57%)
		DUF3508	<731..>853	CDD:288841	43/139 (31%)
		RRM2_RBM26_like	886..957	CDD:240704	27/72 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170580491
Domainoid	1	1.000	93	1.000	Domainoid score	I7509
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	357	1.000	Inparanoid score	I2193
OMA	1	1.010	-	-		QHG48662
OrthoDB	1	1.010	-	-		D324834at33208
OrthoFinder	1	1.000	-	-		FOG0002919
OrthoInspector	1	1.000	-	-		otm26519
orthoMCL	1	0.900	-	-		OOG6_106329
Panther	1	1.100	-	-	O	PTHR14398
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1927
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.910