Protein Alignment: swm and RBM27

• Sequence 1: NP_001260586.1
• Gene: swm
• FlyBaseID: FBgn0002044
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: XP_005268523.1
• Gene: RBM27
• HGNCID: 29243
• Length: 1061
• Species: Homo sapiens
• Alignment Length: 1303
• Identity: 323/1304 (25%)
• Similarity: 488/1304 (37%)
• Gaps: 482/1304 (37%)

  Fly     1 MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFV 65
            |::|:.|.||.||:.:|||:||||.||||.||:||:||||.:|:||....:||||||.:||:.||
Human     1 MLIEDVDALKSWLAKLLEPICDADPSALANYVVALVKKDKPEKELKAFCADQLDVFLQKETSGFV 65

  Fly    66 ERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNV 130
            ::||:::.::.||     ||:                                   .|..|:...
Human    66 DKLFESLYTKNYL-----PLL-----------------------------------EPVKPEPKP 90

  Fly   131 IKPDSNQVK---LEQASQDAREAEALAFISQEAGIAMHVPTDAKPAFDQHKTKDSHNQQSA-SNY 191
            :..:..::|   .::.:::.|:.....:.|         |...:....:.:|::...:... .:|
Human    91 LVQEKEEIKEEVFQEPAEEERDGRKKKYPS---------PQKTRSESSERRTREKKREDGKWRDY 146

  Fly   192 QHHHVRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERA 256
            ..::.|:..                        |.:|    .|.||.|:..||:||..|||..|:
Human   147 DRYYERNEL------------------------YREK----YDWRRGRSKSRSKSRGLSRSRSRS 183

  Fly   257 FRRSRSRDRRVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSH 321
            ..||:.||...|..|                   |..|..|...|             |....|:
Human   184 RGRSKDRDPNRNVVE-------------------HRERSKFKSER-------------NDLESSY 216

  Fly   322 SRSMSPERNARRNQNSPDRVQTAQANLIPAPVAPPAPVEHPA-----------SH---------- 365
            ....:|..|:....:|       .|..||:.|...||..|..           :|
Human   217 VPVSAPPPNSSEQYSS-------GAQSIPSTVTVIAPAHHSENTTESWSNYYNNHSSSNSFGRNL 274

  Fly   366 -PRQRCRDFDEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDAPEIWARSGGPPPGA 429
             |::||||:||:|:||.|:.|.:|||.:|:|.:.:    .:.||..:.|           ||||
Human   275 PPKRRCRDYDERGFCVLGDLCQFDHGNDPLVVDEV----ALPSMIPFPP-----------PPPG- 323

  Fly   430 GQGPVPPPTQPGQTTINPFSG---NVRPTTLMSGSGPSPMGVPNPADYARNP-----GAPPQAAM 486
                :|||..||. .:.|..|   ...|     |.||.|...|.|....|.|     |.||.:.:
Human   324 ----LPPPPPPGM-LMPPMPGPGPGPGP-----GPGPGPGPGPGPGHSMRLPVPQGHGQPPPSVV 378

  Fly   487 MPFPFNP-------------------------TAVTTPLQRQLI--------------------- 505
            :|.|..|                         |.:..||.:.|:
Human   379 LPIPRPPITQSSLINSRDQPGTSAVPNLASVGTRLPPPLPQNLLYTVSERQPMYSREHGAAASER 443

  Fly   506 ---------------------------------PIPVV------DG----APTGGVAEVGKRRF- 526
                                             |.|:|      ||    ||:  :...|:.::
Human   444 LQLGTPPPLLAARLVPPRNLMGSSIGYHTSVSSPTPLVPDTYEPDGYNPEAPS--ITSSGRSQYR 506

  Fly   527 ---------------------ELEDTVAIADVPTKRKVP--INSR-------------------- 548
                                 ::....|...:.|:..||  |||.
Human   507 QFFSRTQTQRPNLIGLTSGDMDVNPRAANIVIQTEPPVPVSINSNITRVVLEPDSRKRAMSGLEG 571

  Fly   549 -------LGPRVNPNM---------QQHNSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYE 597
                   ||.:.|.|.         |..|:.||::|:|:.||.|..||.||:|||.||||||:::
Human   572 PLTKKPWLGKQGNNNQNKPGFLRKNQYTNTKLEVKKIPQELNNITKLNEHFSKFGTIVNIQVAFK 636

  Fly   598 GDPEAAIVTFSTHAEANVAYRSTEAVLNNRFIKVFWHND--------SSGADVGQMNQMGGGGGG 654
            ||||||::.:.|:.||..|..|||||||||||:|.||.:        ||...:.|..|.
Human   637 GDPEAALIQYLTNEEARKAISSTEAVLNNRFIRVLWHRENNEQPTLQSSAQLLLQQQQT------ 695

  Fly   655 GGRKNASQYHLHNVP------------AVPT------------PNADGAKISNANPLTE--AGAG 693
              ..:.||.| |::|            :.|:            |...||.:.|..|:..  ..||
Human   696 --LSHLSQQH-HHLPQHLHQQQVLVAQSAPSTVHGGIQKMMSKPQTSGAYVLNKVPVKHRLGHAG 757

  Fly   694 NIGTPATEQANTAAPASMRLKLNTTTAGGSAGGAAGAGAPGSGRPLNPAANAAS----------- 747
            ...:.|:...|              .:||:.........||..:.:..::|..:
Human   758 GNQSDASHLLN--------------QSGGAGEDCQIFSTPGHPKMIYSSSNLKTPSKLCSGSKSH 808

  Fly   748 -----IRKKQEEQQKAVHQLANGLRKRKQELLQSYMKQMKTALELVERMDQQDP-QRAPTLQTIK 806
                 ::||||..     :|...:||::||:|:..::..|..:..:|:.....| :||..::|:|
Human   809 DVQEVLKKKQEAM-----KLQQDMRKKRQEVLEKQIECQKMLISKLEKNKNMKPEERANIMKTLK 868

  Fly   807 VLQMTIDKLRKEIKADQDQLQAQMQQQQQQQQPPVKKTKEQQKKELLDMELELIAQQQEGNDTTA 871
            .|...|.:|:.|:|.           ......|...|||.:.:|||||.||:|..:...|.|||.
Human   869 ELGEKISQLKDELKT-----------SSAVSTPSKVKTKTEAQKELLDTELDLHKRLSSGEDTTE 922

  Fly   872 IQKRLEELQ---RNLGVGSAANNKSTHYAPASGAPGGGAGRKRPNLPEGPTR---VDRRPKAIVV 930
            ::|:|.:||   ..||:......|:      ..:.|.|.||.|.....|...   ||.||||:.|
Human   923 LRKKLSQLQVEAARLGILPVGRGKT------MSSQGRGRGRGRGGRGRGSLNHMVVDHRPKALTV 981

  Fly   931 TGFAAEEADFVLGHFKNFGEISKHDVDREIPQLILSYATRLNAEQAVLRGKMYKDKRLQISWAPV 995
            .||..||.:.:|.||....:                             |..:||:||||||
Human   982 GGFIEEEKEDLLQHFSTANQ-----------------------------GPKFKDRRLQISW--- 1014

  Fly   996 VTPAPAPMAAPVEKSAAPGDMSVSLENPKQLIQSVSESESLLGSDTLPELRLEDEEEDEESEDRS 1060
                        .|...|   |:|.|..:   :.|.|.|:......||:   :|:|:::|.|.||
Human  1015 ------------HKPKVP---SISTETEE---EEVKEEETETSDLFLPD---DDDEDEDEYESRS 1058

  Fly  1061 WRR 1063
            |||
Human  1059 WRR 1061

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
swm	NP_001260586.1	RRM1_RBM26_like	561..634	CDD:240703	44/73 (60%)
		RRM2_RBM26_like	921..992	CDD:240704	22/71 (31%)
RBM27	XP_005268523.1	PWI	7..72	CDD:295364	39/65 (60%)
		zf-CCCH	278..300	CDD:279036	13/22 (59%)
		RRM_RBM27	600..675	CDD:240961	45/75 (60%)
		DUF342	<814..903	CDD:302792	28/105 (27%)
		RRM_SF	972..1014	CDD:302621	22/71 (31%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C334654051
eggNOG	1	0.900				E1_KOG2135
Hieranoid	1	1.000
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	375	1.000	Inparanoid score	I2081
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D324834at33208
OrthoFinder	1	1.000				FOG0002051
OrthoInspector	1	1.000				T609818
orthoMCL	1	0.900				OOG5_129444
Panther	1	1.100			O	PTHR14398
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R3653
TreeFam	1	0.960
User_Submission	0	0.000	Not matched by this tool.
	13	12.800