Protein Alignment swm and Rbm27

DIOPT Version :10

• Sequence 1: NP_001260586.1
• Gene: swm / 35235
• FlyBaseID: FBgn0002044
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: XP_008770401.1
• Gene: Rbm27 / 361317
• RGDID: 1311966
• Length: 1066
• Species: Rattus norvegicus
• Alignment Length: 1303
• Identity: 328/1303 - (25%)
• Similarity: 508/1303 - (38%)
• Gaps: 477/1303 - (36%)

  Fly     1 MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFV 65
            |::|:.|.||.||:.:|||:||||.||||.||:||:||||.:|:||....:||||||.:||:.||
  Rat     1 MLIEDVDALKSWLAKLLEPICDADPSALANYVVALVKKDKPEKELKAFCADQLDVFLQKETSGFV 65

  Fly    66 ERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNV 130
            ::||:::.::.||. |..|:                                   .|.|.|
  Rat    66 DKLFESLYTKNYLP-PLEPV-----------------------------------KPEPKP---- 90

  Fly   131 IKPDSNQVK---LEQASQDAREAEALAFISQEAGIAMHVPTDAKPAFDQHKTKDSHNQQSA-SNY 191
            :..:..::|   .::.:::.|:.....:.|         |..::....:.:|::...:... .:|
  Rat    91 LVQEKEEIKEEVFQEPAEEERDVRKKKYPS---------PQKSRSESSERRTREKKREDGKWRDY 146

  Fly   192 QHHHVRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERA 256
            :.::.|:..                        |.:|    .|.||.|:..||:||..|||..|:
  Rat   147 ERYYERNEL------------------------YREK----YDWRRGRSKSRSKSRGLSRSRSRS 183

  Fly   257 FRRSRSRD--RRVNEREKTQ-RQFRN---------KSPPGSQTDNRHHGRRNF--------DRRR 301
            ..||:.||  |.|..||::: :..||         .:||.:.::....|.::.        ....
  Rat   184 RGRSKDRDPNRNVEHRERSKFKSERNDLESSYVPVSAPPPNSSEQYSSGAQSIPSTVTVIAPAHH 248

  Fly   302 IGGNADDRPRFGNNKSRRSHSRSMSPERNARRNQNSPDRVQTAQANLIPAPVAPPAPVEHPASHP 366
            .....:....:.||     ||.|.|..||                        ||         |
  Rat   249 SENTTESWSNYYNN-----HSSSNSFGRN------------------------PP---------P 275

  Fly   367 RQRCRDFDEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDAPEIWARSGGPPPGAGQ 431
            ::||||:||:|:||.|:.|.:|||.:|:|.:.:    .:.||..:.|           ||||
  Rat   276 KRRCRDYDERGFCVLGDLCQFDHGNDPLVVDEV----ALPSMIPFPP-----------PPPG--- 322

  Fly   432 GPVPPPTQPGQTTINPFSG---NVRPTTLMSGSGPSPMGVPNPADYARNP-----GAPPQAAMMP 488
              :|||..||. .:.|..|   ...|     |.||.|...|.|....|.|     |.||.:.::|
  Rat   323 --LPPPPPPGM-LMPPMPGPGPGPGP-----GPGPGPGPGPGPGHSMRLPVPQGHGQPPPSVVLP 379

  Fly   489 FPFNPTAVTT-------------------------PLQRQLI----------------------- 505
            .|..|.:.::                         ||.:.|:
  Rat   380 IPRPPISQSSLINSRDQPGTSAVPNLAPVGARLPPPLPQNLLYTVSERQPMYSREHGAAASERLQ 444

  Fly   506 -------------------------------PIPVV------DG----APTGGVAEVGKRRF--- 526
                                           |.|:|      ||    ||:  :...|:.::
  Rat   445 LGTPPPLLAARLVPPRNLMGSSIGYHTSVSSPTPLVPDTYEPDGYNPEAPS--ITSSGRSQYRQF 507

  Fly   527 -------------------ELEDTVAIADVPTKRKVP--INSR---------------------- 548
                               :.....|...:.|:..||  |||.
  Rat   508 FSRAQTQRPNLIGLTSGDMDANPRAANIVIQTEPPVPVSINSNITRVVLEPESRKRAISGLEGPL 572

  Fly   549 -----LGPRVNPNM---------QQHNSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYEGD 599
                 ||.:.|.|.         |..|:.||::|:|:.||.|..||.||:|||.||||||:::||
  Rat   573 TKKPWLGKQGNNNQSKPGFLRKNQYTNTKLEVKKIPQELNNITKLNEHFSKFGTIVNIQVAFKGD 637

  Fly   600 PEAAIVTFSTHAEANVAYRSTEAVLNNRFIKVFWHNDS-------SGADV--GQMNQMGGGGGGG 655
            ||||::.:.|:.||..|..|||||||||||:|.||.::       |.|.:  .|.:.:
  Rat   638 PEAALIQYLTNEEARKAISSTEAVLNNRFIRVLWHRENNEQPALQSSAQILLQQQHTL------- 695

  Fly   656 GRKNASQYHLHNVP------------AVPT------------PNADGAKISNANPLTEAGAGNIG 696
              .:.||.| ||:|            :.|:            |...||.:.|..|:..    .:|
  Rat   696 --SHLSQQH-HNLPQHLHPQQVMVTQSSPSSVHGGIQKMMGKPQTSGAYVLNKVPVKH----RLG 753

  Fly   697 TPATEQANTAAPASMRLKLNTTTAGGSAGGAAGA-GAPGSGRPLNPAANAAS------------- 747
            ...|.|::|:.      .||.|  |||:|..... ..||..:.:..::|..:
  Rat   754 HATTNQSDTSH------LLNQT--GGSSGDDCPVFSTPGHPKTIYSSSNLKAPSKLCSGSKSHDV 810

  Fly   748 ---IRKKQEEQQKAVHQLANGLRKRKQELLQSYMKQMKTALELVERMDQQDP-QRAPTLQTIKVL 808
               ::||||..     :|...:||::||:|:..::..|..:..:|:.....| :||..::|:|.|
  Rat   811 QEVLKKKQEAM-----KLQQDMRKKRQEMLEKQIECQKMLISKLEKNKNMKPEERANIMKTLKEL 870

  Fly   809 QMTIDKLRKEIKADQDQLQAQMQQQQQQQQPPVKKTKEQQKKELLDMELELIAQQQEGNDTTAIQ 873
            ...|.:|:.|:|.           ......|...|||.:.:|||||.||:|..:...|.|||.::
  Rat   871 GEKISQLKDELKT-----------SSAVSTPSKVKTKTEAQKELLDTELDLHKRLSSGEDTTELR 924

  Fly   874 KRLEELQ---RNLGVGSAANNKSTHYAPASGAPGGGAGRKRPNLPEGPTRVDRRPKAIVVTGFAA 935
            |:|.:||   ..||:......|:.    :|...|.|.||.|.........||.||||:...||..
  Rat   925 KKLSQLQVEAARLGILPVGRGKTM----SSQGRGRGRGRGRGRGSLNHMVVDHRPKALPAGGFIE 985

  Fly   936 EEADFVLGHFKNFGEISKHDVDREIPQLILSYATRLNAEQAVLRGKMYKDKRLQISWAPVVTPAP 1000
            ||.:.:|.||....:.||                             :||:||||||
  Rat   986 EEKEELLQHFSATNQSSK-----------------------------FKDRRLQISW-------- 1013

  Fly  1001 APMAAPVEKSAAPGDMSVSLENPKQLIQ-----SVSESESLLGSDTLPELRLEDEEEDEESEDRS 1060
                   .|...|   |:|.|..::.::     ::.|:|:   ||..  |..:|:|:::|.|.||
  Rat  1014 -------HKPKVP---SISTETEEEEVKEEVKSAIRETET---SDLF--LHDDDDEDEDEYESRS 1063

  Fly  1061 WRR 1063
            |||
  Rat  1064 WRR 1066

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
swm	NP_001260586.1	RRM1_RBM26_like	561..634	CDD:409702	43/72 (60%)
		RRM2_RBM26_like	921..992	CDD:409703	21/70 (30%)
Rbm27	XP_008770401.1	PWI	7..70	CDD:460224	38/62 (61%)
		zf-CCCH	276..299	CDD:459885	12/22 (55%)
		RRM_RBM27	599..674	CDD:409939	45/74 (61%)
		PRK03918	<806..>933	CDD:235175	42/142 (30%)
		RRM_SF	971..1013	CDD:473069	21/70 (30%)