Protein Alignment swm and rbm27

DIOPT Version :10

• Sequence 1: NP_001260586.1
• Gene: swm / 35235
• FlyBaseID: FBgn0002044
• Length: 1063
• Species: Drosophila melanogaster
• Sequence 2: XP_002935312.3
• Gene: rbm27 / 100498053
• XenbaseID: XB-GENE-6037527
• Length: 1007
• Species: Xenopus tropicalis
• Alignment Length: 1199
• Identity: 335/1199 - (27%)
• Similarity: 511/1199 - (42%)
• Gaps: 328/1199 - (27%)

  Fly     1 MILENSDKLKDWLSVVLEPLCDADSSALARYVIALLKKDKSDKDLKRIMIEQLDVFLSEETTRFV 65
            |::||.|..|.||:.:|||:||||..|||.|||||:|||||:|:||.|..:||||||.:||..||
 Frog     1 MLIENVDAFKTWLAKLLEPICDADPMALANYVIALVKKDKSEKELKAICADQLDVFLQKETNGFV 65

  Fly    66 ERLFDAIASEEYLTVPAAPLITASSASTAELTVDQELALVIDGPQDDIEAVLVADSPPPPPKDNV 130
            :::||::.::.||  |....|.|.        :.||        :::|:..:....|.|.|....
 Frog    66 DKMFDSLHTKVYL--PPEETINAD--------LKQE--------KEEIKEEVPEKRPMPTPGMET 112

  Fly   131 IKPDSNQVKLEQASQDAREAEALAFISQEAGIAMHVPTDAK-PAFDQHKTKDSHNQQSASNYQHH 194
            .:.:.:..|.:..|.....::     |.|..|......|.| ..:|:|:.|          |...
 Frog   113 YEEERDSRKKKHPSPPRNRSD-----SSERRIREKKREDGKYREYDRHRDK----------YDWR 162

  Fly   195 HVRSASPPGRSSGVSGSGGGGPGGAGLAAGYADKENQPRDSRRRRASLRSRSRSRSRSNERAFRR 259
            ..||.||                                  .:.:::.|||||||.||.||...|
 Frog   163 RGRSKSP----------------------------------TKSKSTNRSRSRSRGRSRERESTR 193

  Fly   260 SRSRDRRVNEREKTQRQFRNKSPPGSQTDNRHHGRRNFDRRRIGGNADDRPRFGNNKSRRSHSRS 324
            :|.     |.:..:.:|        |.:.::|..|:.|:..|:...|...|        .|.|.:
 Frog   194 NRG-----NAKGNSVQQ--------SSSASQHRERQKFESERMELEAAYTP--------SSQSSA 237

  Fly   325 MSPERNARRNQNSPDRVQTAQANLIPAPVAPPAPVEHPAS-----------H-----------PR 367
            :|.|:.           .::....||:.|...||..||.|           |           |:
 Frog   238 ISAEQQ-----------YSSGGQAIPSTVTVIAPAHHPESTTEIWSNYYNNHNPPNSFSRIPPPK 291

  Fly   368 QRCRDFDEKGYCVRGETCPWDHGVNPVVFEGINNTSLMMSMREYNPDAPEIWARSGGPPPGAGQG 432
            :||||:||:|:||.|:.|.:|||.:|:|.:.::..|::       |..|.    .|.||||....
 Frog   292 RRCRDYDERGFCVLGDLCQYDHGNDPLVVDEVSLPSMI-------PFPPP----PGLPPPGILLP 345

  Fly   433 PVPPPT-QPGQTTINPFSGNVRPTTLMSGSGPSP-MGVPNPAD-YARNP---------GAPPQAA 485
            |:|.|. ......:.|.:....|..|.:.|.|.| .|:.|..| .|.|.         |.||:
 Frog   346 PIPDPAHNMRMPVLRPHNQPPPPAVLPAPSLPLPHSGLLNNRDRLATNTVPSLAPIVGGLPPR-- 408

  Fly   486 MMPFP---------------FNPTAVT----------TPLQRQLIPIPVVDGAPTGGVAEVGKRR 525
             :|.|               :||.|.:          |.||||          ||.....:|...
 Frog   409 -IPPPNLLYSVSEHTYEPDGYNPEAPSLTNTGRPGYQTFLQRQ----------PTQRSNLIGLTS 462

  Fly   526 FELEDTVAIADVPTKRKVP-----------INSRL--------------GP---------RVNPN 556
            .:::.....|::..:.:.|           :|:|:              ||         :.|.|
 Frog   463 CDMDTAPRAANIVIQTEPPPPPPPPSTVGVVNNRVVVEPDRKRTAGNMDGPFAKKPWMDKQGNHN 527

  Fly   557 ---------MQQHNSSLELRKVPRGLNTIAHLNNHFAKFGKIVNIQVSYEGDPEAAIVTFSTHAE 612
                     :|..|:.||:||:|:.||.|..||.||:|||.||||||:::||||.|::.:.|:.|
 Frog   528 HNKTGFVKKIQYTNTKLEVRKIPQDLNNITKLNEHFSKFGTIVNIQVAFQGDPEGALIQYLTNDE 592

  Fly   613 ANVAYRSTEAVLNNRFIKVFWHNDSSGADVGQMNQ------------MGGGGGGGGRK------N 659
            |..|..|||||||||||:|.||.:::.....|..|            :...|.|..:|      |
 Frog   593 ARRAISSTEAVLNNRFIRVLWHRENNEQQHTQPQQHHLTTASTTQTPIAPAGQGHLQKVIPKAIN 657

  Fly   660 ASQYHLHNVPAVPTPNADGAKISNANPLTEAGAGNIGTPATEQANTAAPASMRLKLNTTTAGGSA 724
            ...|.|:.:|    |.....:.|::...|...|.|  .|::.:.|...|.|..|.....::|
 Frog   658 QGSYVLNKLP----PKQRLGQTSSSPSDTTYLASN--QPSSGEENQTLPPSTSLSKMVYSSG--- 713

  Fly   725 GGAAGAGAPGSGRPLNPAANA---ASIRKKQEEQQKAVHQLANGLRKRKQELLQSYMKQMKTALE 786
                  |...|.:|..|:...   .:::||||     ..:|...:||:|||:|:   ||::....
 Frog   714 ------GLKTSNKPAAPSKTVDVQDALKKKQE-----ALKLQQDMRKKKQEMLE---KQIECQKM 764

  Fly   787 LVERMDQ----QDPQRAPTLQTIKVLQMTIDKLRKEIKADQDQLQAQMQQQQQQQQPPVKKTKEQ 847
            |:.|:::    :..:|...::|:|.|...|.:::.|:|.    |.|          |...|:|.:
 Frog   765 LISRLEKNKSMKAEERTEIMKTLKTLDEKISQVKDELKT----LSA----------PSKLKSKTE 815

  Fly   848 QKKELLDMELELIAQQQEGNDTTAIQKRLEELQ---RNLGVGSAANNKSTHYAPASGAPGGGAGR 909
            .:|||||.|::...:...|.|||.::|:|..||   ..||:...:..|:        .||...||
 Frog   816 AQKELLDAEMDFHKRLSSGEDTTELRKKLSLLQVEAARLGILPPSRGKT--------LPGQSRGR 872

  Fly   910 KRPNLPEGPTR-----VDRRPKAIVVTGFAAEEADFVLGHFKNFGEISKHDVDREIPQLILSYAT 969
            .|.:...|...     ||.|||.|.|.||..:|.:.:|.||..||::.....:...|.:||::.|
 Frog   873 GRGHGTRGRGSLSHMVVDHRPKTISVVGFYDKEKEELLQHFAKFGDVEDLKEEEFPPSVILTFKT 937

  Fly   970 RLNAEQAVLRGKMYKDKRLQISWAPVVTPAPAPMAAPVEKSAAPGDMSVSLENPKQLIQSVSESE 1034
            |..||.|..:|..:|.::||:||....||:                :|..:|..:...:....|:
 Frog   938 RQEAENAANQGSKFKGRKLQVSWHKPKTPS----------------ISTEIEEDETKEEEAETSD 986

  Fly  1035 SLLGSDTLPELRLEDEEEDEESEDRSWRR 1063
            ..|..|       |||:|||: |.|||||
 Frog   987 PFLHDD-------EDEDEDED-ESRSWRR 1007

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
swm	NP_001260586.1	RRM1_RBM26_like	561..634	CDD:409702	43/72 (60%)
		RRM2_RBM26_like	921..992	CDD:409703	27/70 (39%)
rbm27	XP_002935312.3	PWI	7..70	CDD:460224	38/62 (61%)
		zf-CCCH	291..314	CDD:459885	12/22 (55%)
		RRM_RBM27	541..616	CDD:409939	45/74 (61%)
		ERM_helical	<731..826	CDD:466641	33/116 (28%)
		RRM_SF	889..960	CDD:473069	27/70 (39%)