DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Alp12 and Alp8

DIOPT Version :9

Sequence 1:	NP_001188848.1	Gene:	Alp12 / 35218	FlyBaseID:	FBgn0032779	Length:	596	Species:	Drosophila melanogaster
Sequence 2:	NP_001286709.1	Gene:	Alp8 / 37540	FlyBaseID:	FBgn0034712	Length:	533	Species:	Drosophila melanogaster

Alignment Length:	540	Identity:	190/540 - (35%)
Similarity:	287/540 - (53%)	Gaps:	43/540 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    62 RLFLISVVFSALLITAMCIGFVVH--YGMSGDVG-------DMETVSYWPVDLPKEQ--KEWYDQ 115
            :|.|..::..||..||:|....||  ..::|...       |:.|..|.|   |:|.  :.||:.
  Fly     7 QLVLPILLLLALAGTALCGVQEVHNVLELTGQAANKLKFSTDVATEKYTP---PEEMDPQYWYNI 68

  Fly   116 GIDELQKAVS-RQFNRRRAKNVILFVGDGMGPNTVTAARIL------GVKEEGLLRWEQFPDMGL 173
            ..:|:.|.:. .|.|.::|||:|:|:||||..:||.|||||      ...||..|.:|:||..||
  Fly    69 ADEEITKRLQLPQPNSQKAKNIIMFLGDGMPLSTVAAARILKGQRQGNTGEESSLSFERFPYTGL 133

  Fly   174 LKTYCADKQVPDSFSTATALFGGVKVNYETGGVDANVPLGNCSASLKEDHHVQTILKWAQVDGMR 238
            .:|||::.|||||..||||...|||.|....||.|.|...||:||....:.:.:|.:|||..|..
  Fly   134 SRTYCSNAQVPDSACTATAYLCGVKTNIVNIGVSAAVEYNNCTASQDPANRLTSIAEWAQNAGKS 198

  Fly   239 TGFVTTTRVTHATPAALYAHVPDRRWECESGMPA-EAQGQGCMDIARQLIEQPTGQSINVIMGGG 302
            ||.||||.:|||:|:..||...:|.|||::.:.: ......|:|:|.||:.|..|::..|:.|||
  Fly   199 TGIVTTTTLTHASPSGAYAKTANRMWECDTDVTSYGVDANSCIDMATQLVTQTPGKNFEVMFGGG 263

  Fly   303 R-QMLVSDVTGSAADPLDTWAGQSKDGRDLIRDWRLKKADEGVSHAVVQNNRELWNLNGQDVDYV 366
            . :.|.:.:..|..:|     |:..||.:|:..|: ...|.||   :|.|..:|..||...|..|
  Fly   264 MGKFLPNSIVDSHGNP-----GERSDGVNLLSRWQ-GLHDGGV---LVTNRNQLLKLNVSAVSSV 319

  Fly   367 LGIFANGHLMYDHERDRSDAGMPSLSNMTLKALEVLG-NSDKGFLLVVEAGLIDQAHHRGNARKA 430
            :|:|.:..:.:..|.|  |...|:||.:|...::.|. |.:.|:...:|.||||..:|...|..|
  Fly   320 IGLFQSKLMNFHLEAD--DTYQPTLSELTEVTIKKLSQNKEHGYFAFIEGGLIDYGNHYTKAGYA 382

  Fly   431 LSEVLELNAAVESTLSFLKSSDRLDETLVIVTADHSHSLTINGHPDRGSSILGL-AGNSKTEGTP 494
            |.|.||...|::    ..:....:::||::|||||.|:::|.|:|.||:.|||: ..::...|..
  Fly   383 LDEALEFEKAIQ----LARDMTDIEDTLIVVTADHGHAVSIAGYPGRGTPILGINQHDTDINGVQ 443

  Fly   495 YTTLTYGTSYQGFQVDPQTQSRKDPTADDITAWEYTQQAAINTDENLHGGSDVTIHADGAMSYLF 559
            |:.|.|......: :|...|  :.|..|.:.:.:....:.|..|:.:|.|.||.|.|.|..|:||
  Fly   444 YSVLNYAAGPNQY-LDENGQ--RIPLDDILGSDDAITPSYIPKDQGVHSGEDVGIFASGPQSHLF 505

  Fly   560 HGVHEQSYVAHAISYALRIG 579
            .||.:||.:.|.::||..||
  Fly   506 TGVMQQSTIPHLMAYAACIG 525

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Alp12	NP_001188848.1	ALP_like	134..579	CDD:304875	165/454 (36%)
Alp8	NP_001286709.1	ALP_like	88..525	CDD:304875	165/454 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45466674
Domainoid	1	1.000	141	1.000	Domainoid score	I216
eggNOG	1	0.900	-	-		E1_COG1785
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	146	1.000	Inparanoid score	I224
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D216917at33208
OrthoFinder	1	1.000	-	-		FOG0000192
OrthoInspector	1	1.000	-	-		otm51319
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR11596
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X159
	10	9.900