Protein Alignment brat and wech

DIOPT Version :10

• Sequence 1: NP_001188842.2
• Gene: brat / 35197
• FlyBaseID: FBgn0010300
• Length: 1061
• Species: Drosophila melanogaster
• Sequence 2: XP_314006.5
• Gene: wech / 1274803
• VectorBaseID: AGAMI1_005942
• Length: 875
• Species: Anopheles gambiae
• Alignment Length: 1135
• Identity: 250/1135 - (22%)
• Similarity: 397/1135 - (34%)
• Gaps: 393/1135 - (34%)

  Fly     2 ASSPTPSLDSMRGGAN--------SIESYEHAGYLS--------DSPLTLSGSSP---PASDSAI 47
            |||...:..:..||.|        ...|.:|..:.|        |:|...| |.|   |.|::..
Mosquito     8 ASSMQITPQTANGGPNGGGPDGPGDFNSNDHIFFSSLFNALPCWDAPHKAS-SGPVMVPQSNNNT 71

  Fly    48 CSDEYTGGSSVKSRSEVTVINGHHPISASVSSSSSASSSSCSSSSSSSSSSSSSSSSTSGLSGCG 112
            ..|.    .|:....::        :.::|..:....|||..||.:....:.....|:.|.||.|
Mosquito    72 SLDR----DSISITEDI--------LFSNVLGAIGTGSSSSGSSGAIGMGNVGIIGSSHGSSGGG 124

  Fly   113 STSSSVISANNVASSNGPGVIGSNLQSSNNGGNSGISSLVVGAGKGSNSSSNSSSSNTSANGSPP 177
            ..:.:|.|||.:.     |||||:..|.        :.|..|....:| |||.|...:|......
Mosquito   125 HLAHAVTSANEIF-----GVIGSSCASH--------AQLTPGTSPQTN-SSNGSHCPSSVGAICG 175

  Fly   178 RCTACKSKCSDAVAKCFECQSYLCANCVTAH---EFM--HCFNGHNV--------CLIKGFEAST 229
            ||.      :.|.::|.:|...||.:|...|   .|.  ||....|.        |::.|
Mosquito   176 RCD------THASSRCLDCNDVLCEDCTQLHGKNAFTKDHCVISINTISPIGSAPCMVPG----- 229

  Fly   230 TGTPLSVGS-PSNNPASNEFKYASSLTMMLQQQQQLDSQQQQQQQQLLPAQPMSQLSKIVLAAAA 293
            .|.....|| |||.|                                             :||
Mosquito   230 NGHGSGNGSGPSNGP---------------------------------------------MAA-- 247

  Fly   294 QANSQEQQREDSIYGSLHPQQQQQQQQQQQRQLFCPRHKQELLKFSCRTCCILVCKECIVLEHST 358
                          |...|.              |..| .|:|::.|.:|..:||:||.:.:|.
Mosquito   248 --------------GLSEPH--------------CDVH-GEVLRYLCESCKKVVCQECTLWDHK- 282

  Fly   359 GLHELENVQSPGMTTSTGSTANESALQTLLADMRGKIGEIVGIAGNSDQNLT---KVKLQYQKAH 420
                 ::...|....|.|  |:|..:..|.:   ||:|... |..:.|:.:|   .|:....:|.
Mosquito   283 -----DHSCIPVANISHG--ASEKIMSILES---GKLGTKY-IKASIDRAVTYSQAVERDAMEAS 336

  Fly   421 NELNETHQFFASMLDERKTELLKELETLYTAKVNSNNSWQQRSRDLIDKGLATCEAVERSPAPPS 485
            ..:.:..:.|....::|:..||..::...          ||:...|.|: :|...|.....:..|
Mosquito   337 ARIRKAMRHFILAAEDRERTLLDRVDKFR----------QQKLTSLSDQ-MAGLRAALAGLSQTS 390

  Fly   486 SLLTEAL---LLRKSLE--QQLQTGIQEMQLPFEIEFMSNYQSIQ-------------------- 525
            .:||:||   .:..|:|  :.|.||..:|:     :|.:.|:::|
Mosquito   391 DMLTKALDSVSVMGSMEIAKTLTTGESQME-----QFAAMYKNLQPKEEFITFVAPNFELLQEIR 450

  Fly   526 -------AGVRNTFGYIRANSSDG----GPTGMSL----TSNGHG------------KQPPIARP 563
                   .|.|:  ..:.:|||..    ||||.:.    .|||.|            .:.||.|
Mosquito   451 MQGDVMLVGQRS--NSVSSNSSGNASLQGPTGPNCGGVNPSNGVGGVGVVGSVGNILTRRPIVR- 512

  Fly   564 TQSASNSSASSAGSGHHGHHQQSHHHGHHNHHQTAHHQQLQAQSSLHGLGLGLSGASLLDSSSSA 628
                |.:.|...||                             ||...:|.|.||:|.:..||..
Mosquito   513 ----STTPAQRIGS-----------------------------SSWEPMGKGSSGSSSVLGSSPT 544

  Fly   629 GGAVGAFSNGGLLLGGRDRNALAVEQHFGELMPKRGGGGYTGSNG--SATSAVAHYNPYEKWSNG 691
            ...:|......:|               |:.:|        |.|.  :|..||.
Mosquito   545 SFGIGPIPGAPIL---------------GQCIP--------GCNNHVAAKPAVG----------- 575

  Fly   692 GSDNLFSSVTSGVSGSSAVADAFASLSAVGGSVVSGAGAGGSTVSSESLLDLTNKLLSATIYPPK 756
                  .|:|.|..|..            .|.|   :...|.||      |...::|.|.....:
Mosquito   576 ------PSLTFGFDGHE------------DGQV---SRPWGITV------DKDGQILVADRRNNR 613

  Fly   757 SQIKRQKMIYHCKFGEFGVMEGQFTEPSGVAVNAQNDIIVADTNNHRIQIFDKEGRFKFQFGECG 821
            .||......:..|||..|...|||..|:|:..:.|..|||.|.:|||:|:|...|.|..:||..|
Mosquito   614 VQIFYPDGTFKLKFGSKGTANGQFDLPAGICTDGQGRIIVVDKDNHRVQVFSAGGLFLLKFGSYG 678

  Fly   822 KRDSQLLYPNRVAVVRNSGDIIVTERSPTHQIQIYNQYGQFVRKFGATILQH---------PRGV 877
            |...|..||..|| |...|:|:||: |..|:||:::..|.|:.::....:.|         |||.
Mosquito   679 KECGQFQYPWDVA-VNTKGEILVTD-SRNHRIQLFSPDGLFISRYSFDGVNHSRYLKGLTTPRGA 741

  Fly   878 TVDNKGRIIVVECKVMRVIIFD-----------QNGNVLHKFGCSKHLEFPNGVVVNDKQEIFIS 931
            ....:|.||:.:.:..|:::.|           ..|:.:|:|      ..|:|:..:|...:.::
Mosquito   742 CFTPQGDIIISDFENHRLLLIDATLSKVLAAKGHEGSAVHEF------SRPSGICCDDDGRVIVA 800

  Fly   932 DNRAHCVKVFNYEGQYLRQIGGEGITNYPIGVGINSNGEILIADNHNNFNLTIFTQDGQLISALE 996
            |::...|.||:.:.::|          :.:.:..:|||.:.|                    .::
Mosquito   801 DSKNQRVLVFSPQLEFL----------WAVEIRPSSNGLLAI--------------------GMD 835

  Fly   997 SKVKHAQCFDVALMDDGSVVL---ASKDYR 1023
            .|.:.:   ||||:.||.:|:   .|.|.|
Mosquito   836 EKDRPS---DVALLPDGRLVVMVETSPDAR 862

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
brat	NP_001188842.2	Bbox1_BRAT-like	178..222	CDD:380871	14/56 (25%)
		Bbox2_BRAT-like	326..366	CDD:380856	11/39 (28%)
		CC_brat-like	382..503	CDD:467844	26/128 (20%)
		NHL_brat_like	760..1030	CDD:271329	76/287 (26%)
		NHL repeat	783..819	CDD:271329	15/35 (43%)
		NHL repeat	830..871	CDD:271329	14/40 (35%)
		NHL repeat	874..910	CDD:271329	11/46 (24%)
		NHL repeat	914..954	CDD:271329	8/39 (21%)
		NHL repeat	959..997	CDD:271329	4/37 (11%)
		NHL repeat	1002..1027	CDD:271329	10/25 (40%)
wech	XP_314006.5	None