Protein Alignment Ddc and gad2

DIOPT Version :10

• Sequence 1: NP_724163.1
• Gene: Ddc / 35190
• FlyBaseID: FBgn0000422
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: NP_001017708.2
• Gene: gad2 / 550403
• ZFINID: ZDB-GENE-030909-9
• Length: 583
• Species: Danio rerio
• Alignment Length: 519
• Identity: 131/519 - (25%)
• Similarity: 210/519 - (40%)
• Gaps: 83/519 - (15%)

  Fly    39 PEFKDFAKTM------VDFIAEYL-ENI-RERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDI 95
            |.....||||      ||.:..|: |:. |..:|:....|..|.........::||...|::...
Zfish    97 PALDGDAKTMNFLQEVVDILLAYIVESFDRSTKVIDFHYPNELLQRNNWELSDEPETLDDILISC 161

  Fly    96 ERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTWIASPACTELEVVMMDWLGKM 160
            ...:...:...| |::.....|......:.||.|:.......||:..:|....||.|.   |.||
Zfish   162 RATLKYAIKTAH-PRYFNQLSTGLDMVGLAADWLTSTANTNMFTYEVAPVFVLLEYVT---LKKM 222

  Fly   161 LELPAEFLACSGGKGGGVIQGTASESTLVALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQ 225
            .|:    :....|.|.|:.....:.|.:.|:|.|:.|...||||     ...:.:.:||.:.|:.
Zfish   223 REI----IGWQDGHGDGIFSPGGAISNMYAMLLARYKMFPEVKE-----KGMSSVPRLVAFTSEH 278

  Fly   226 AHSSVERAGLLGGVKLRSV----QSENHRMRGAALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFD 286
            :|.|:::.....|:...||    ..|..:|..:.||:.|.:...:|.:||:...|.|||...|||
Zfish   279 SHFSIKKGAAALGIGTESVICIKADERGKMIPSDLERRIIEAKQKGYVPFFVSATAGTTVYGAFD 343

  Fly   287 YLDECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMKGIESADSFNFNPHKWMLVNFDCSAMWLK 351
            .|.....:..||::|:|||.|:.||..:..::|..:.|:|.|:|..:||||.|.|...|||:.::
Zfish   344 PLIAIADICKKHDVWMHVDGAWGGSLLMSRKHRWKLNGVERANSMTWNPHKMMAVPLQCSALLVR 408

  Fly   352 DPSWVVNAFNVDPLYL----KH-DMQGSAPDYRHWQIPLGRRFRALKLWFVLRLYGVENLQAHIR 411
            :...:.:...:...||    || |:|....|.   .:..||.....|||.:.|..|....:|.|.
Zfish   409 EEGLMQSCNQMQACYLFQQDKHYDLQYDTGDK---ALQCGRHVDIFKLWLMWRAKGTIGFEAQID 470

  Fly   412 RHCNFAKQF--------GDLCVADSRFELAAEINMGLVCF--------RLKGSNERNEALLKRIN 460
            :....::..        |...|.|.:   ....|   |||        .|:...||    :||
Zfish   471 KCLELSEYLYNKIKDREGYQMVFDGK---PQHTN---VCFWYLPPGVRYLEDKVER----MKR-- 523

  Fly   461 GRGHIHLVPAKIK------------------DVYFLRMAICSRFTQSEDMEYSWKEVSAAADEM 506
                :|.|...||                  .|.|.||.|.:.....||:::..:|:.....::
Zfish   524 ----LHKVAPVIKARMMEYGTTMVSYQPQGDKVNFFRMVISNPAATFEDIDFLIEEIERLGQDL 583

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:395219	103/400 (26%)
gad2	NP_001017708.2	PHA00540	102..>156	CDD:133910	14/53 (26%)
		Pyridoxal_deC	136..506	CDD:395219	103/391 (26%)
		TIM-like beta/alpha barrel domains	511..>561	CDD:473867	14/59 (24%)