Protein Alignment Ddc and DDC

DIOPT Version :10

• Sequence 1: NP_724163.1
• Gene: Ddc / 35190
• FlyBaseID: FBgn0000422
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: XP_047275888.1
• Gene: DDC / 1644
• HGNCID: 2719
• Length: 521
• Species: Homo sapiens
• Alignment Length: 520
• Identity: 290/520 - (55%)
• Similarity: 369/520 - (70%)
• Gaps: 45/520 - (8%)

  Fly    36 MEAPEFKDFAKTMVDFIAEYLENIRERRVLPEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIM 100
            |.|.||:...|.|||::|.|:|.|..|:|.|:|:||||:||||.|||::|:.::|::.|:|::||
Human     1 MNASEFRRRGKEMVDYMANYMEGIEGRQVYPDVEPGYLRPLIPAAAPQEPDTFEDIINDVEKIIM 65

  Fly   101 PGVTHWHSPKFHAYFPTANSYPAIVADMLSGAIACIGFTW------------------------- 140
            |||||||||.|.||||||:||||::||||.|||.||||:|
Human    66 PGVTHWHSPYFFAYFPTASSYPAMLADMLCGAIGCIGFSWGCCLGRGSNQPIRCVQSLGAGGSLE 130

  Fly   141 ----------------IASPACTELEVVMMDWLGKMLELPAEFLACSGGKGGGVIQGTASESTLV 189
                            .|||||||||.|||||||||||||..||....|:|||||||:|||:|||
Human   131 KGLAPACKPPVPPYLEAASPACTELETVMMDWLGKMLELPKAFLNEKAGEGGGVIQGSASEATLV 195

  Fly   190 ALLGAKAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSSVERAGLLGGVKLRSVQSE-NHRMRG 253
            |||.|:.|.:..::...||..:..|:.|||.|.|||||||||||||:|||||:::.|: |..||.
Human   196 ALLAARTKVIHRLQAASPELTQAAIMEKLVAYSSDQAHSSVERAGLIGGVKLKAIPSDGNFAMRA 260

  Fly   254 AALEKAIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGPVGNKHNLWIHVDAAYAGSAFICPEY 318
            :||::|:|:|.|.|||||:.|.|||||..|:||.|.|.||:.||.::|:|||||||||||||||:
Human   261 SALQEALERDKAAGLIPFFMVATLGTTTCCSFDNLLEVGPICNKEDIWLHVDAAYAGSAFICPEF 325

  Fly   319 RHLMKGIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDPLYLKHDMQ--GSAPDYRHW 381
            |||:.|:|.|||||||||||:||||||||||:|..:.:..||.:||.||||..|  |...|||||
Human   326 RHLLNGVEFADSFNFNPHKWLLVNFDCSAMWVKKRTDLTGAFRLDPTYLKHSHQDSGLITDYRHW 390

  Fly   382 QIPLGRRFRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSRFELAAEINMGLVCFRLK 446
            |||||||||:||:|||.|:|||:.|||:||:|...:.:|..|...|.|||:..|:.:||||||||
Human   391 QIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLK 455

  Fly   447 GSNERNEALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFTQSEDMEYSWKEV-SAAADEMEQEQ 510
            |||:.|||||:|||....|||||..::|.:.||.|||||..:|..::.:|:.: ..|||.:..|:
Human   456 GSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVESAHVQRAWEHIKELAADVLRAER 520

  Fly   511  510
            Human   521  520

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:395219	242/419 (58%)
DDC	XP_047275888.1	Pyridoxal_deC	35..455	CDD:395219	242/419 (58%)