Protein Alignment Ddc and Hdc

DIOPT Version :10

• Sequence 1: NP_724163.1
• Gene: Ddc / 35190
• FlyBaseID: FBgn0000422
• Length: 510
• Species: Drosophila melanogaster
• Sequence 2: XP_006498847.1
• Gene: Hdc / 15186
• MGIID: 96062
• Length: 681
• Species: Mus musculus
• Alignment Length: 506
• Identity: 247/506 - (48%)
• Similarity: 335/506 - (66%)
• Gaps: 17/506 - (3%)

  Fly     1 MSHIPISNTIPTKQTDGNGKANISPDKLDPKVSIDMEAPEFKDFAKTMVDFIAEYLENIRERRVL 65
            :|.||....:|.:|               |..:..:....|....|.|||:|::||..:|||:|.
Mouse     8 LSPIPSPRCLPKRQ---------------PLSTTTLRVRCFILSGKEMVDYISQYLSTVRERQVT 57

  Fly    66 PEVKPGYLKPLIPDAAPEKPEKWQDVMQDIERVIMPGVTHWHSPKFHAYFPTANSYPAIVADMLS 130
            |.|:||||:..:|.:|||:|:.|..:..||||||||||.||.||..|||:|...|:|:::.|||:
Mouse    58 PNVQPGYLRAQLPASAPEEPDSWDSIFGDIERVIMPGVVHWQSPHMHAYYPALTSWPSLLGDMLA 122

  Fly   131 GAIACIGFTWIASPACTELEVVMMDWLGKMLELPAEFL-ACSGGKGGGVIQGTASESTLVALLGA 194
            .||.|:||||.:||||||||:.:||||.|||.||..|| .....:||||:|.|.|||||:|||.|
Mouse   123 DAINCLGFTWASSPACTELEMNIMDWLAKMLGLPEYFLHHHPSSRGGGVLQSTVSESTLIALLAA 187

  Fly   195 KAKKLKEVKELHPEWDEHTILGKLVGYCSDQAHSSVERAGLLGGVKLRSVQ-SENHRMRGAALEK 258
            :..|:..:|...|:.:|.::..:||.|.|||||||||:|||:..||:|.:. .:|..:||.||:|
Mouse   188 RKNKILAMKACEPDANESSLNARLVAYTSDQAHSSVEKAGLISLVKIRFLPVDDNFSLRGEALQK 252

  Fly   259 AIEQDVAEGLIPFYAVVTLGTTNSCAFDYLDECGPVGNKHNLWIHVDAAYAGSAFICPEYRHLMK 323
            |||:|..:||:|.:...|||||..||||.|.|.||:.....||:||||||||:||:|||.|..::
Mouse   253 AIEEDKQQGLVPVFVCATLGTTGVCAFDRLSELGPICASEGLWLHVDAAYAGTAFLCPELRGFLE 317

  Fly   324 GIESADSFNFNPHKWMLVNFDCSAMWLKDPSWVVNAFNVDPLYLKHDMQGSAPDYRHWQIPLGRR 388
            |||.||||.|||.|||:|:|||:..|:||...:...|:|:|:||:|...|:|.|:.||||||.||
Mouse   318 GIEYADSFTFNPSKWMMVHFDCTGFWVKDKYKLQQTFSVNPIYLRHANSGAATDFMHWQIPLSRR 382

  Fly   389 FRALKLWFVLRLYGVENLQAHIRRHCNFAKQFGDLCVADSRFELAAEINMGLVCFRLKGSNERNE 453
            ||::|||||:|.:||:|||||:|.....||.|..|..:|..||:.|:.::|||.|||||.|...|
Mouse   383 FRSIKLWFVIRSFGVKNLQAHVRHGTEMAKYFESLVRSDPSFEIPAKRHLGLVVFRLKGPNCLTE 447

  Fly   454 ALLKRINGRGHIHLVPAKIKDVYFLRMAICSRFTQSEDMEYSWKEVSAAAD 504
            ::||.|...|.:.|:||.|:|...:|..:.|:||..||:...|..:..||:
Mouse   448 SVLKEIAKAGQLFLIPATIQDKLIIRFTVTSQFTTKEDILRDWHLIQEAAN 498

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ddc	NP_724163.1	Pyridoxal_deC	70..446	CDD:395219	204/377 (54%)
Hdc	XP_006498847.1	Pyridoxal_deC	62..440	CDD:395219	204/377 (54%)