DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10700 and aifm4

DIOPT Version :9

Sequence 1:	NP_609942.1	Gene:	CG10700 / 35183	FlyBaseID:	FBgn0032754	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_005157647.1	Gene:	aifm4 / 791218	ZFINID:	ZDB-GENE-070112-2282	Length:	530	Species:	Danio rerio

Alignment Length:	522	Identity:	191/522 - (36%)
Similarity:	308/522 - (59%)	Gaps:	24/522 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 VVCHKLEVQENEMRQ--VDASGIPSILLVKQSGILRAVGAMCPHRGAPLAKGVLSRNRVRCPWHG 73
            :||.:.::|:.:|::  ||.:   .||||:.:|...|||.:|.|.||||.||.|..:|||||:||
Zfish    12 MVCLESDLQDGQMKEVLVDEN---KILLVRNNGEFTAVGGLCSHYGAPLIKGTLIGDRVRCPFHG 73

  Fly    74 VCFNLETGDIENFPGLDSLPCHRVNVDSRGQVLVQVKRSYLLRHARIKSMACRNWQDQRHFVVVG 138
            .|||.:|||||.|||||.||..:|.||. |:|.|...:..|.:  |:|.|:.|........|::|
Zfish    74 ACFNTKTGDIEEFPGLDCLPKFKVKVDG-GKVYVTSDQKNLKK--RVKKMSSRVPGVNHTVVLIG 135

  Fly   139 GGPSGAVCVETLRQEGFTGRLTLVCGEKHLPYDRTRIMNLLNTYTKNLALREEQFYKDYGIEMQL 203
            |||:...|.|||||..:.||:.:|..::.||.|:|::...:|...:.:.||:..|.:.||||:..
Zfish   136 GGPASLQCAETLRQNDYGGRIVMVTKDEQLPLDKTKLSKAMNIEIEKVLLRQSDFLQQYGIEVWT 200

  Fly   204 GVSAERLDTNCNTLHCTNGKTFPYDKIYIATGYSAVTPNIPGVHLKNVKVIRNIGDARSIFKMVD 268
            ....:.:||:..|:...:|....||::.|:||..|.....||..|:|||:::...||..|.: :.
Zfish   201 KKEVKSVDTDAKTVTFQDGTLQNYDQLLISTGGRARPLECPGAELENVKLLQTYEDASEIHR-IS 264

  Fly   269 KSTQVVCLGSSFMAVEATANLVSRARSVTLVARQNVPFKSTLGELIGQRILKLLEENKVDLRMSS 333
            ...:.|.:|:||:.:|..|.|..:|.|||::.....||:::||..||:..:::|||..|....|:
Zfish   265 AGKKAVIVGTSFIGMEVAAYLSDKAASVTVIGTSKFPFQASLGSDIGKMTMQMLEEKNVKFYTSN 329

  Fly   334 GIIRILGNSRGEVVAVKLLDNSRIPCNLLILGTGCQCNTDFLQRSGININPNGSVDVNDFLQTKV 398
            |:..|.|.: |:|..|.|.:...:|.:::|.|.|...|:|||:.:.:.|:.:.:|.|:.|::|.:
Zfish   330 GVAEIRGEN-GKVKEVVLKNGEVLPADIIIAGIGVIPNSDFLKETLVEIDSHKAVVVDKFMKTNI 393

  Fly   399 RNVYVGGDIANAYILGGFP------DRVNISHYGLAQYHGRIAALNMSGHIAKLEAIPFFYTVIF 457
            .:|:..||:.:      ||      .||||.|:.|||.|||||.|:|.....::..:|:|:|::.
Zfish   394 PDVFAAGDVVS------FPLTLVGHKRVNIGHWQLAQAHGRIAGLSMLNRQVEINTVPYFWTMLL 452

  Fly   458 GRAFRSAGYGP-FKDVVIDGSLEDLQFVAYFFDDYDKVTAVASCGRDPMVAQFAELVSQGKELCR 521
            |::.|..|||. :.::|..||.|:.:|:|::..| ::|.|.||...||.||:.||::..||.:.:
Zfish   453 GKSIRYTGYGEGYTEIVFKGSTEERKFLAFYIKD-EEVVAAASLNFDPAVARLAEMLLMGKRITK 516

  Fly   522 CQ 523
            .|
Zfish   517 AQ 518

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10700	NP_609942.1	Rieske_AIFL_N	10..106	CDD:239560	49/96 (51%)
		Pyr_redox_2	135..414	CDD:285266	90/278 (32%)
		Pyr_redox	273..350	CDD:278498	27/76 (36%)
		COG3393	336..>508	CDD:225928	61/178 (34%)
		Reductase_C	464..527	CDD:291425	23/61 (38%)
aifm4	XP_005157647.1	Rieske_AIFL_N	13..105	CDD:239560	49/95 (52%)
		Pyr_redox_2	129..427	CDD:285266	100/305 (33%)
		TIM_phosphate_binding	<132..277	CDD:304361	48/145 (33%)
		Pyr_redox	268..349	CDD:278498	29/81 (36%)
		Reductase_C	446..519	CDD:291425	27/74 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2498
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1909
OMA	1	1.010	-	-		QHG58553
OrthoDB	1	1.010	-	-		D183405at33208
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		mtm6441
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	O	PTHR43557
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R33
SonicParanoid	1	1.000	-	-		X1666
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	13	13.010