DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10700 and aifm5

DIOPT Version :9

Sequence 1:	NP_609942.1	Gene:	CG10700 / 35183	FlyBaseID:	FBgn0032754	Length:	539	Species:	Drosophila melanogaster
Sequence 2:	XP_001920911.2	Gene:	aifm5 / 557064	ZFINID:	ZDB-GENE-091118-96	Length:	543	Species:	Danio rerio

Alignment Length:	529	Identity:	187/529 - (35%)
Similarity:	310/529 - (58%)	Gaps:	23/529 - (4%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 IDPV-----VVCHKLEVQENEMRQVDASGIPSILLVKQSGILRAVGAMCPHRGAPLAKGVLSRNR 66
            :||.     |||...::::.||.:|:. |..::|||:..|:..|:...|.|.||||::||||..|
Zfish    12 LDPEEEVTNVVCDDADLRDGEMMEVEV-GDHNVLLVRCDGVYSAISNQCTHYGAPLSEGVLSGCR 75

  Fly    67 VRCPWHGVCFNLETGDIENFPGLDSLPCHRVNVDSRGQVLVQVKRSYLLRHARIKSMACRNWQDQ 131
            |||||||.|||::|||:|.:||:|.||||:|.|:: .:|.|.||:....:..|:|.|..|:....
Zfish    76 VRCPWHGSCFNVKTGDLEEYPGIDCLPCHKVKVEN-NKVYVSVKKRIRGQPKRVKWMGVRDQSVS 139

  Fly   132 RHFVVVGGGPSGAVCVETLRQEGFTGRLTLVCGEKHLPYDRTRIMNLLNTYTKNLALREEQFYKD 196
            ...:::|||.:..:|.||||||.:.||:.:|..:..||||:||:..::|..:.:|.:|...|:..
Zfish   140 HTVMLLGGGAACLMCAETLRQENYGGRIIMVSRDDLLPYDKTRLSKVMNAESDSLLMRRMDFFHK 204

  Fly   197 YGIEMQLGVSAERLDTNCNTLHCTNGKTFPYDKIYIATGYSAVTPNIPGVHLKNVKVIRNIGDAR 261
            :.||:.|...|..:|||..|:...:|....||:|.||||..|...:.||.:|:.|.::....|||
Zfish   205 HDIEVWLKKEALSIDTNKKTVTFDDGLIQSYDQILIATGCRAKGLDCPGANLERVLMLETPEDAR 269

  Fly   262 SIFKMVDKSTQVVCLGSSFMAVEATANLVSRARSVTLVARQNVPFKSTLGELIGQRILKLLEENK 326
            .: .......:.|.:|:||:.:|..|.|:..:.|:|::....:|::.|||..||:..:.:|||..
Zfish   270 CV-HYACTGCRTVIVGTSFIGMEVAAYLLDTSSSMTVIGSSELPYQKTLGREIGKVTMTMLEEKG 333

  Fly   327 VDLRMSSGIIRILGNSRGEVVAVKLLDNSRIPCNLLILGTGCQCNTDFLQRSGININPNGSVDVN 391
            |...|:..:..:.|.:| .|.||||.....|..:|||:..|...|::||:.|.:.::....|.|:
Zfish   334 VTFYMNDAVAEVQGKNR-RVKAVKLKSGITIEADLLIVAIGVSPNSEFLKGSRVRMDSKNYVIVD 397

  Fly   392 DFLQTKVRNVYVGGDIANAYILGGFP------DRVNISHYGLAQYHGRIAALNMSGHIAKLEAIP 450
            ::::|.:.:||..||:.:      ||      .:|::.|:.:||.|||||||||.....:|..:|
Zfish   398 EYMRTNITDVYCAGDLTS------FPLKMAKGQKVSLGHWQIAQAHGRIAALNMLCREVELNTVP 456

  Fly   451 FFYTVIFGRAFRSAGYGP-FKDVVIDGSLEDLQFVAYFFDDYDKVTAVASCGRDPMVAQFAELVS 514
            :::||:|||..|.||||. :.::|:.|..|:::|:|.:..| .:|.|.|....:|.|:..||.::
Zfish   457 YYWTVLFGRTIRYAGYGEGYTEMVLKGKFENMKFLALYLKD-GEVVAAAGLNVEPAVSVVAERLA 520

  Fly   515 QGKELCRCQ 523
            :|:.:.:.:
Zfish   521 EGRVITKAE 529

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10700	NP_609942.1	Rieske_AIFL_N	10..106	CDD:239560	46/100 (46%)
		Pyr_redox_2	135..414	CDD:285266	90/278 (32%)
		Pyr_redox	273..350	CDD:278498	24/76 (32%)
		COG3393	336..>508	CDD:225928	61/178 (34%)
		Reductase_C	464..527	CDD:291425	18/61 (30%)
aifm5	XP_001920911.2	Rieske_AIFL_N	21..114	CDD:239560	46/94 (49%)
		Pyr_redox_2	140..438	CDD:285266	96/305 (31%)
		Pyr_redox	279..360	CDD:278498	27/81 (33%)
		Reductase_C	457..535	CDD:291425	24/74 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	223	1.000	Domainoid score	I2498
eggNOG	1	0.900	-	-		E1_COG0446
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H135034
Inparanoid	1	1.050	396	1.000	Inparanoid score	I1909
OMA	1	1.010	-	-		QHG58553
OrthoDB	1	1.010	-	-		D183405at33208
OrthoFinder	1	1.000	-	-		FOG0001279
OrthoInspector	1	1.000	-	-		mtm6441
orthoMCL	1	0.900	-	-		OOG6_100481
Panther	1	1.100	-	-	O	PTHR43557
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X1666
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	14	13.840