DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10495 and DUS3L

DIOPT Version :9

Sequence 1:	NP_609939.1	Gene:	CG10495 / 35179	FlyBaseID:	FBgn0032750	Length:	396	Species:	Drosophila melanogaster
Sequence 2:	NP_064560.2	Gene:	DUS3L / 56931	HGNCID:	26920	Length:	650	Species:	Homo sapiens

Alignment Length:	260	Identity:	72/260 - (27%)
Similarity:	116/260 - (44%)	Gaps:	38/260 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    28 APMVRYSKLEFRRLVRLNGVQLAFTPMMISDSINNSE-------KARQNEFSTGADDQPLIAQFA 85
            ||:.....|.|||:.:..|..:....|.:..::...:       |..|.|...|       .|..
Human   310 APLTTCGNLPFRRICKRFGADVTCGEMAVCTNLLQGQMSEWALLKRHQCEDIFG-------VQLE 367

  Fly    86 AKDPTEFVTSAQLI--YPYVDGIDLNCGCPQSWAMAKGYGCGMLRQPELVHQVVQEVRRTLPGDF 148
            ...|......|:|:  ...||.:|:|.|||......||.||.::.:.....|:|:.:.:.|  |.
Human   368 GAFPDTMTKCAELLSRTVEVDFVDINVGCPIDLVYKKGGGCALMNRSTKFQQIVRGMNQVL--DV 430

  Fly   149 SVSVKMRLLGGEESLQRTIDLARQLESAGVTFLTLHGRTPAQKHSKDTLDIPAMSQVRQSLQ--- 210
            .::||:| .|.:|.:.....|..:|...||..:|||||:..|:::|    :.....:.:.:|
Human   431 PLTVKIR-TGVQERVNLAHRLLPELRDWGVALVTLHGRSREQRYTK----LADWQYIEECVQAAS 490

  Fly   211 -IPLIVNGNVESYRDACDMHEQTGAAGVMAARGLLANPALFNSNYPDGKTTPLSCVQQWLDIASA 274
             :||..||::.|:.|| :...|||..|:|.|||.|..|.||         |.:...:.| ||:|:
Human   491 PMPLFGNGDILSFEDA-NRAMQTGVTGIMIARGALLKPWLF---------TEIKEQRHW-DISSS 544

Fly 275 274
Human 545 544

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10495	NP_609939.1	DUS_like_FMN	26..251	CDD:239200	66/235 (28%)
CG10495	NP_609939.1	Dus	28..321	CDD:279540	72/260 (28%)
DUS3L	NP_064560.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	46..120
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	235..284
		DusA	297..576	CDD:223120	72/260 (28%)
		DUS_like_FMN	306..538	CDD:239200	68/251 (27%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0042
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810