Protein Alignment L2HGDH and L2hgdh

DIOPT Version :10

• Sequence 1: NP_609923.2
• Gene: L2HGDH / 35156
• FlyBaseID: FBgn0032729
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001101498.1
• Gene: L2hgdh / 314196
• RGDID: 1306250
• Length: 463
• Species: Rattus norvegicus
• Alignment Length: 424
• Identity: 226/424 - (53%)
• Similarity: 308/424 - (72%)
• Gaps: 10/424 - (2%)

  Fly    37 SSSCGDYDLVVVGGGIVGAASAREIVLRHPSLKVAVLEKECKLAKHQSGHNSGVIHAGIYYKPGT 101
            |||...:|:|:|||||||.||||.::|:||.|.:.|:|||..||.||:|.||||||:||||||.:
  Rat    43 SSSTSSFDIVIVGGGIVGLASARTLILKHPELSIGVVEKEKDLALHQTGRNSGVIHSGIYYKPES 107

  Fly   102 LKARLCVEGMHLAYAYLDEKKIPYKKTGKLIVATDEKEVKLLKDLEKRGIANNVPDLRMIEGSEI 166
            |||:|||||..|.|.|.:.|.|||::.||||||.:::|:..|:.|.:||:.|.|..||:|:..:|
  Rat   108 LKAKLCVEGAALIYEYCNLKGIPYRQCGKLIVAVEQEEIPRLQALYERGLQNGVQGLRLIQQEDI 172

  Fly   167 QEIEPYCQGVMALHSPHTGIVDWGLVTEHYGQDFKQCGGDIYLDFNVSKF-------TETKEGTD 224
            ::.||||:|:||:..|:||||::..|...:.|||::.||.|..||.|...       ..:|:|..
  Rat   173 KKKEPYCRGLMAIDCPYTGIVNYQQVALSFAQDFQEAGGSILKDFEVKDIGIAKEDPPRSKDGMK 237

  Fly   225 YPVTIHGAKPGQTVRTKNVLTCGGLQSDLLAEKTGCPRDPRIVPFRGEYLLLTKEKQHMVKGNIY 289
            ||:.:..:| |:.::.:.|:||.||.||.::|.:||..||:||||||:||:|..||.::||||||
  Rat   238 YPIAVKNSK-GKEIQCRYVVTCAGLYSDRISELSGCNPDPQIVPFRGDYLVLKPEKGYLVKGNIY 301

  Fly   290 PVPDPRFPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINLFELFDALRYPGFVKMASKYIG 354
            ||||.|.||||||||||:|||||||||||||.|||||...|.|..::.:.:...||:|:..:...
  Rat   302 PVPDSRLPFLGVHFTPRLDGSIWLGPNAVLAFKREGYRPFDFNARDIMEVILKSGFIKLVFQNFS 366

  Fly   355 FGLSEMSKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMDLDGNLVDDFVFDRGQGSGALA 419
            :|.||:.|:.|::..:|.|||:||:||..|:.||||||||||:|.|||||||||||  .|:|.:.
  Rat   367 YGASEIYKACFLSETVKHLQKFIPEITTNDVLRGPAGVRAQALDRDGNLVDDFVFD--GGAGEIG 429

  Fly   420 KRVLHCRNAPSPGATSSLAIAKMIADKIENEFSI 453
            .|:||.||||||.|||||||::|||::::..|.:
  Rat   430 DRILHVRNAPSPAATSSLAISRMIAEEVQQRFKL 463

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L2HGDH	NP_609923.2	DAO	56..447	CDD:477422	213/397 (54%)
L2hgdh	NP_001101498.1	DAO	61..457	CDD:477422	213/398 (54%)