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Protein Alignment L2HGDH and lhgd-1

DIOPT Version :9

Sequence 1:	NP_609923.2	Gene:	L2HGDH / 35156	FlyBaseID:	FBgn0032729	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_503730.1	Gene:	lhgd-1 / 178733	WormBaseID:	WBGene00021564	Length:	433	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	242/445 - (54%)
Similarity:	315/445 - (70%)	Gaps:	15/445 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRRSLLNV--GVAAPNESTATHKRSQHSSSSCGDYDLVVVGGGIVGAASAREIVLRHPSLKVAVL 73
            |.|....|  |::.|.:          .|.....||||:|||||||.|:||::::..|.||||::
Worm     2 LNRGTFQVFRGISGPPK----------KSVDLPKYDLVIVGGGIVGCATARQLLIEKPQLKVALI 56

  Fly    74 EKECKLAKHQSGHNSGVIHAGIYYKPGTLKARLCVEGMHLAYAYLDEKKIPYKKTGKLIVATDEK 138
            |||.:||.||||||||||||||||.||:|||:|||||:.|:|.:.|::|:|||||||||||.:.:
Worm    57 EKEKELAVHQSGHNSGVIHAGIYYTPGSLKAKLCVEGLDLSYEFFDKEKVPYKKTGKLIVAVEPE 121

  Fly   139 EVKLLKDLEKRGIANNVPDLRMIEGSEIQEIEPYCQGVMALHSPHTGIVDWGLVTEHYGQDFKQC 203
            ||..|..|..|...|...|:.||:.|:|.|:||:|:|:.||.||||||||||.||:.:|:||::.
Worm   122 EVPRLDALFSRAQTNGCRDIEMIDSSKITELEPHCRGLKALWSPHTGIVDWGYVTKRFGEDFEKR 186

  Fly   204 GGDIYLDFNVSKFTETKEGTDYPVTIHGAKPGQTVRTKNVLTCGGLQSDLLAEKTGCPRDPRIVP 268
            ||.||..:.:.|.::..: ..||:.:..........|||::||.|||||.:|..:||..||:|||
Worm   187 GGKIYTSYPLEKISDNHD-PGYPIRVSSGPALAEFETKNLITCAGLQSDRVAALSGCSTDPKIVP 250

  Fly   269 FRGEYLLLTKEKQHMVKGNIYPVPDPRFPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINL 333
            ||||||||..||:|:||.|||||||||||||||||||||:|.||||||||||.|||||::..|:.
Worm   251 FRGEYLLLKPEKRHLVKTNIYPVPDPRFPFLGVHFTPRMNGDIWLGPNAVLAYKREGYSYFSISP 315

  Fly   334 FELFDALRYPGFVKMASKYIGFGLSEMSKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMD 398
            .:|.::|.|.|..|:..|:..||:.|:.:..:|..|:|.||::||::...|:.||||||||||||
Worm   316 SDLLESLSYSGMQKLVKKHFTFGIKELYRGVWIAAQVKQLQRFIPELKLSDVTRGPAGVRAQAMD 380

  Fly   399 LDGNLVDDFVFDRGQGSGALAKRVLHCRNAPSPGATSSLAIAKMIADKIENEFSI 453
            ..||||||||||  .|:|.|:..::|.||||||.|||||||||||..:..|.|.:
Worm   381 SAGNLVDDFVFD--SGTGKLSPLLMHVRNAPSPAATSSLAIAKMITSEAINRFKL 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
L2HGDH	NP_609923.2	DAO	56..447	CDD:477422	223/390 (57%)
lhgd-1	NP_503730.1	DAO	24..427	CDD:477422	234/405 (58%)

Information from Original Tools:

Software error:

Can't use an undefined value as an ARRAY reference at /www/www.flyrnai.org/docroot/cgi-bin/DRSC_prot_align.pl line 1034.

For help, please send mail to the webmaster (ritg@hms.harvard.edu), giving this error message and the time and date of the error.

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-
Domainoid	1	1.000	-	-
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-