DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment L2HGDH and Y45G12B.3

DIOPT Version :9

Sequence 1:	NP_001286076.1	Gene:	L2HGDH / 35156	FlyBaseID:	FBgn0032729	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	NP_503730.1	Gene:	Y45G12B.3 / 178733	WormBaseID:	WBGene00021564	Length:	433	Species:	Caenorhabditis elegans

Alignment Length:	445	Identity:	242/445 - (54%)
Similarity:	315/445 - (70%)	Gaps:	15/445 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly    11 LRRSLLNV--GVAAPNESTATHKRSQHSSSSCGDYDLVVVGGGIVGAASAREIVLRHPSLKVAVL 73
            |.|....|  |::.|.:          .|.....||||:|||||||.|:||::::..|.||||::
Worm     2 LNRGTFQVFRGISGPPK----------KSVDLPKYDLVIVGGGIVGCATARQLLIEKPQLKVALI 56

  Fly    74 EKECKLAKHQSGHNSGVIHAGIYYKPGTLKARLCVEGMHLAYAYLDEKKIPYKKTGKLIVATDEK 138
            |||.:||.||||||||||||||||.||:|||:|||||:.|:|.:.|::|:|||||||||||.:.:
Worm    57 EKEKELAVHQSGHNSGVIHAGIYYTPGSLKAKLCVEGLDLSYEFFDKEKVPYKKTGKLIVAVEPE 121

  Fly   139 EVKLLKDLEKRGIANNVPDLRMIEGSEIQEIEPYCQGVMALHSPHTGIVDWGLVTEHYGQDFKQC 203
            ||..|..|..|...|...|:.||:.|:|.|:||:|:|:.||.||||||||||.||:.:|:||::.
Worm   122 EVPRLDALFSRAQTNGCRDIEMIDSSKITELEPHCRGLKALWSPHTGIVDWGYVTKRFGEDFEKR 186

  Fly   204 GGDIYLDFNVSKFTETKEGTDYPVTIHGAKPGQTVRTKNVLTCGGLQSDLLAEKTGCPRDPRIVP 268
            ||.||..:.:.|.::..: ..||:.:..........|||::||.|||||.:|..:||..||:|||
Worm   187 GGKIYTSYPLEKISDNHD-PGYPIRVSSGPALAEFETKNLITCAGLQSDRVAALSGCSTDPKIVP 250

  Fly   269 FRGEYLLLTKEKQHMVKGNIYPVPDPRFPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINL 333
            ||||||||..||:|:||.|||||||||||||||||||||:|.||||||||||.|||||::..|:.
Worm   251 FRGEYLLLKPEKRHLVKTNIYPVPDPRFPFLGVHFTPRMNGDIWLGPNAVLAYKREGYSYFSISP 315

  Fly   334 FELFDALRYPGFVKMASKYIGFGLSEMSKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMD 398
            .:|.::|.|.|..|:..|:..||:.|:.:..:|..|:|.||::||::...|:.||||||||||||
Worm   316 SDLLESLSYSGMQKLVKKHFTFGIKELYRGVWIAAQVKQLQRFIPELKLSDVTRGPAGVRAQAMD 380

  Fly   399 LDGNLVDDFVFDRGQGSGALAKRVLHCRNAPSPGATSSLAIAKMIADKIENEFSI 453
            ..||||||||||  .|:|.|:..::|.||||||.|||||||||||..:..|.|.:
Worm   381 SAGNLVDDFVFD--SGTGKLSPLLMHVRNAPSPAATSSLAIAKMITSEAINRFKL 433

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
L2HGDH	NP_001286076.1	PRK11728	56..447	CDD:183292	223/390 (57%)
L2HGDH	NP_001286076.1	NADB_Rossmann	69..440	CDD:304358	213/370 (58%)
Y45G12B.3	NP_503730.1	PRK11728	24..427	CDD:183292	234/405 (58%)
Y45G12B.3	NP_503730.1	NADB_Rossmann	26..420	CDD:304358	229/396 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160156079
Domainoid	1	1.000	478	1.000	Domainoid score	I203
eggNOG	1	0.900	-	-		E1_COG0579
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11767
Inparanoid	1	1.050	487	1.000	Inparanoid score	I788
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG61343
OrthoDB	1	1.010	-	-		D1310154at2759
OrthoFinder	1	1.000	-	-		FOG0005741
OrthoInspector	1	1.000	-	-		oto18949
orthoMCL	1	0.900	-	-		OOG6_101318
Panther	1	1.100	-	-	LDO	PTHR43104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2601
SonicParanoid	1	1.000	-	-		X4135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	15	14.840