Protein Alignment: L2HGDH and Y45G12B.3

• Sequence 1: NP_001286076.1
• Gene: L2HGDH
• FlyBaseID: FBgn0032729
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_503730.1
• Gene: Y45G12B.3
• WormBaseID: WBGene00021564
• Length: 433
• Species: Caenorhabditis elegans
• Alignment Length: 445
• Identity: 242/446 (54%)
• Similarity: 315/446 (71%)
• Gaps: 15/446 (3%)

  Fly    11 LRRSLLNV--GVAAPNESTATHKRSQHSSSSCGDYDLVVVGGGIVGAASAREIVLRHPSLKVAVL 73
            |.|....|  |::.|.:          .|.....||||:|||||||.|:||::::..|.||||::
 Worm     2 LNRGTFQVFRGISGPPK----------KSVDLPKYDLVIVGGGIVGCATARQLLIEKPQLKVALI 56

  Fly    74 EKECKLAKHQSGHNSGVIHAGIYYKPGTLKARLCVEGMHLAYAYLDEKKIPYKKTGKLIVATDEK 138
            |||.:||.||||||||||||||||.||:|||:|||||:.|:|.:.|::|:|||||||||||.:.:
 Worm    57 EKEKELAVHQSGHNSGVIHAGIYYTPGSLKAKLCVEGLDLSYEFFDKEKVPYKKTGKLIVAVEPE 121

  Fly   139 EVKLLKDLEKRGIANNVPDLRMIEGSEIQEIEPYCQGVMALHSPHTGIVDWGLVTEHYGQDFKQC 203
            ||..|..|..|...|...|:.||:.|:|.|:||:|:|:.||.||||||||||.||:.:|:||::.
 Worm   122 EVPRLDALFSRAQTNGCRDIEMIDSSKITELEPHCRGLKALWSPHTGIVDWGYVTKRFGEDFEKR 186

  Fly   204 GGDIYLDFNVSKFTETKEGTDYPVTIHGAKPGQTVRTKNVLTCGGLQSDLLAEKTGCPRDPRIVP 268
            ||.||..:.:.|.::..: ..||:.:..........|||::||.|||||.:|..:||..||:|||
 Worm   187 GGKIYTSYPLEKISDNHD-PGYPIRVSSGPALAEFETKNLITCAGLQSDRVAALSGCSTDPKIVP 250

  Fly   269 FRGEYLLLTKEKQHMVKGNIYPVPDPRFPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINL 333
            ||||||||..||:|:||.|||||||||||||||||||||:|.||||||||||.|||||::..|:.
 Worm   251 FRGEYLLLKPEKRHLVKTNIYPVPDPRFPFLGVHFTPRMNGDIWLGPNAVLAYKREGYSYFSISP 315

  Fly   334 FELFDALRYPGFVKMASKYIGFGLSEMSKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMD 398
            .:|.::|.|.|..|:..|:..||:.|:.:..:|..|:|.||::||::...|:.||||||||||||
 Worm   316 SDLLESLSYSGMQKLVKKHFTFGIKELYRGVWIAAQVKQLQRFIPELKLSDVTRGPAGVRAQAMD 380

  Fly   399 LDGNLVDDFVFDRGQGSGALAKRVLHCRNAPSPGATSSLAIAKMIADKIENEFSI 453
            ..||||||||||  .|:|.|:..::|.||||||.|||||||||||..:..|.|.:
 Worm   381 SAGNLVDDFVFD--SGTGKLSPLLMHVRNAPSPAATSSLAIAKMITSEAINRFKL 433

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L2HGDH	NP_001286076.1	PRK11728	56..447	CDD:183292	223/391 (57%)
		NADB_Rossmann	69..440	CDD:304358	214/371 (58%)
Y45G12B.3	NP_503730.1	PRK11728	24..427	CDD:183292	234/406 (58%)
		NADB_Rossmann	26..420	CDD:304358	230/397 (58%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C173100865
eggNOG	1	0.900				E1_COG0579
Hieranoid	1	1.000
Homologene	1	1.000				H11767
Inparanoid	1	1.050	486	1.000	Inparanoid score	I785
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D1310154at2759
OrthoFinder	1	1.000				FOG0006192
OrthoInspector	1	1.000				T474342
orthoMCL	1	0.900				OOG5_127956
Panther	1	1.100			LDO	PTHR43104
Phylome	1	0.910		0.667	Consistency score
RoundUp	1	1.030		avgDist	Average_Evolutionary_Distance	R2601
TreeFam	0	0.000	Not matched by this tool.
	13	12.840