DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment L2HGDH and l2hgdh

DIOPT Version :9

Sequence 1:	NP_001286076.1	Gene:	L2HGDH / 35156	FlyBaseID:	FBgn0032729	Length:	455	Species:	Drosophila melanogaster
Sequence 2:	XP_002938171.1	Gene:	l2hgdh / 100145085	XenbaseID:	XB-GENE-5764342	Length:	453	Species:	Xenopus tropicalis

Alignment Length:	418	Identity:	244/418 - (58%)
Similarity:	309/418 - (73%)	Gaps:	10/418 - (2%)

- Green bases have known domain annotations that are detailed below.

  Fly    43 YDLVVVGGGIVGAASAREIVLRHPSLKVAVLEKECKLAKHQSGHNSGVIHAGIYYKPGTLKARLC 107
            ||:|||||||||.||||:::||||:|:.||||||.::|.|||||||||||:||||.||:||||||
Frog    39 YDVVVVGGGIVGLASARQLILRHPALRFAVLEKEKEIALHQSGHNSGVIHSGIYYTPGSLKARLC 103

  Fly   108 VEGMHLAYAYLDEKKIPYKKTGKLIVATDEKEVKLLKDLEKRGIANNVPDLRMIEGSEIQEIEPY 172
            |.|..|.|.|.|:|.||||:.||||||..:.|:..|:.|.:||:.||||.||:|...:|:|.|||
Frog   104 VRGAALIYEYCDQKGIPYKQCGKLIVAVKQPEIPRLQALYERGLQNNVPGLRLIGAKDIKEKEPY 168

  Fly   173 CQGVMALHSPHTGIVDWGLVTEHYGQDFKQCGGDIYLDFNVSKFTETKE-------GTDYPVTIH 230
            |:|||||.||:||||::..|.:.|..||...||.:..||.|:......|       |.:|||.|.
Frog   169 CRGVMALESPYTGIVNYKQVAQSYKDDFCDAGGSVLTDFEVTDIKMVNESPAGSVQGIEYPVAIK 233

  Fly   231 GAKPGQTVRTKNVLTCGGLQSDLLAEKTGCPRDPRIVPFRGEYLLLTKEKQHMVKGNIYPVPDPR 295
            ..| |:.|..|.||||.||.||.:::.:||..:||||||||:||:|..||.::|||||||||:||
Frog   234 NNK-GEEVHCKYVLTCAGLFSDRVSQVSGCSAEPRIVPFRGDYLVLKPEKCYLVKGNIYPVPNPR 297

  Fly   296 FPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINLFELFDALRYPGFVKMASKYIGFGLSEM 360
            |||||||||||||||:||||||:||.|||||...|.|..:..:|:.|.|..|:..|.:.:|:.||
Frog   298 FPFLGVHFTPRMDGSVWLGPNAILAFKREGYRLCDFNARDFKEAVTYSGLHKLVLKNLSYGMGEM 362

  Fly   361 SKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMDLDGNLVDDFVFDRGQGSGALAKRVLHC 425
            .:::|:|.|:|.|||:||:::..||.|||:||||||:|.|||||||||||  .|||.||..:||.
Frog   363 YRAFFLNAQLKELQKFIPELSFNDIARGPSGVRAQALDRDGNLVDDFVFD--GGSGDLANCILHV 425

  Fly   426 RNAPSPGATSSLAIAKMIADKIENEFSI 453
            ||||||.|||||||::|||.::|..|.:
Frog   426 RNAPSPAATSSLAISEMIASEVEERFGL 453

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
L2HGDH	NP_001286076.1	PRK11728	56..447	CDD:183292	231/397 (58%)
L2HGDH	NP_001286076.1	NADB_Rossmann	69..440	CDD:304358	218/377 (58%)
l2hgdh	XP_002938171.1	PRK11728	51..447	CDD:183292	231/398 (58%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	479	1.000	Domainoid score	I419
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H11767
Inparanoid	1	1.050	489	1.000	Inparanoid score	I1394
OMA	1	1.010	-	-		QHG61343
OrthoDB	1	1.010	-	-		D1310154at2759
OrthoFinder	1	1.000	-	-		FOG0005741
OrthoInspector	1	1.000	-	-		oto103110
Panther	1	1.100	-	-	LDO	PTHR43104
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2601
SonicParanoid	1	1.000	-	-		X4135
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	12	12.110