Protein Alignment: L2HGDH and l2hgdh

• Sequence 1: NP_001286076.1
• Gene: L2HGDH
• FlyBaseID: FBgn0032729
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: XP_002938171.1
• Gene: l2hgdh
• XenbaseID: XB-GENE-5764342
• Length: 453
• Species: Xenopus tropicalis
• Alignment Length: 418
• Identity: 244/419 (58%)
• Similarity: 309/419 (74%)
• Gaps: 10/419 (2%)

  Fly    43 YDLVVVGGGIVGAASAREIVLRHPSLKVAVLEKECKLAKHQSGHNSGVIHAGIYYKPGTLKARLC 107
            ||:|||||||||.||||:::||||:|:.||||||.::|.|||||||||||:||||.||:||||||
 Frog    39 YDVVVVGGGIVGLASARQLILRHPALRFAVLEKEKEIALHQSGHNSGVIHSGIYYTPGSLKARLC 103

  Fly   108 VEGMHLAYAYLDEKKIPYKKTGKLIVATDEKEVKLLKDLEKRGIANNVPDLRMIEGSEIQEIEPY 172
            |.|..|.|.|.|:|.||||:.||||||..:.|:..|:.|.:||:.||||.||:|...:|:|.|||
 Frog   104 VRGAALIYEYCDQKGIPYKQCGKLIVAVKQPEIPRLQALYERGLQNNVPGLRLIGAKDIKEKEPY 168

  Fly   173 CQGVMALHSPHTGIVDWGLVTEHYGQDFKQCGGDIYLDFNVSKFTETKE-------GTDYPVTIH 230
            |:|||||.||:||||::..|.:.|..||...||.:..||.|:......|       |.:|||.|.
 Frog   169 CRGVMALESPYTGIVNYKQVAQSYKDDFCDAGGSVLTDFEVTDIKMVNESPAGSVQGIEYPVAIK 233

  Fly   231 GAKPGQTVRTKNVLTCGGLQSDLLAEKTGCPRDPRIVPFRGEYLLLTKEKQHMVKGNIYPVPDPR 295
            ..| |:.|..|.||||.||.||.:::.:||..:||||||||:||:|..||.::|||||||||:||
 Frog   234 NNK-GEEVHCKYVLTCAGLFSDRVSQVSGCSAEPRIVPFRGDYLVLKPEKCYLVKGNIYPVPNPR 297

  Fly   296 FPFLGVHFTPRMDGSIWLGPNAVLALKREGYTWGDINLFELFDALRYPGFVKMASKYIGFGLSEM 360
            |||||||||||||||:||||||:||.|||||...|.|..:..:|:.|.|..|:..|.:.:|:.||
 Frog   298 FPFLGVHFTPRMDGSVWLGPNAILAFKREGYRLCDFNARDFKEAVTYSGLHKLVLKNLSYGMGEM 362

  Fly   361 SKSWFINLQIKALQKYIPDITEYDIQRGPAGVRAQAMDLDGNLVDDFVFDRGQGSGALAKRVLHC 425
            .:::|:|.|:|.|||:||:::..||.|||:||||||:|.|||||||||||  .|||.||..:||.
 Frog   363 YRAFFLNAQLKELQKFIPELSFNDIARGPSGVRAQALDRDGNLVDDFVFD--GGSGDLANCILHV 425

  Fly   426 RNAPSPGATSSLAIAKMIADKIENEFSI 453
            ||||||.|||||||::|||.::|..|.:
 Frog   426 RNAPSPAATSSLAISEMIASEVEERFGL 453

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
L2HGDH	NP_001286076.1	PRK11728	56..447	CDD:183292	231/398 (58%)
		NADB_Rossmann	69..440	CDD:304358	219/378 (58%)
l2hgdh	XP_002938171.1	PRK11728	51..447	CDD:183292	231/399 (58%)
		NADB_Rossmann	65..452	CDD:304358	224/390 (57%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930				C173501748
eggNOG	1	0.900				E1_COG0579
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000				H11767
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010
OrthoDB	1	1.010				D1310154at2759
OrthoFinder	1	1.000				FOG0006192
OrthoInspector	0	0.000	Not matched by this tool.
Phylome	1	0.910		0.667	Consistency score
RoundUp	0	0.000	Not matched by this tool.
TreeFam	1	0.960
	8	7.720