DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment CG10348 and PRDM16

DIOPT Version :10

Sequence 1:NP_609904.2 Gene:CG10348 / 35132 FlyBaseID:FBgn0032707 Length:540 Species:Drosophila melanogaster
Sequence 2:NP_071397.3 Gene:PRDM16 / 63976 HGNCID:14000 Length:1276 Species:Homo sapiens


Alignment Length:697 Identity:184/697 - (26%)
Similarity:256/697 - (36%) Gaps:260/697 - (37%)


- Green bases have known domain annotations that are detailed below.


  Fly    20 VYPALGLIP-----TSYISH-----VPYDLASSASVAATSSSSTSPTTTSATTTGRLQHQHSHQQ 74
            :||...|:|     .|.::|     :|..|.:.|....::.|::|..||:|...           
Human   522 LYPRPPLLPPTSLLKSPLNHTQDAKLPSPLGNPALPLVSAVSNSSQGTTAAAGP----------- 575

  Fly    75 HQTLNHHAKGKRRSSFDQPLDLRLAHKRKT---DLVDQGPMEDENSNLIMFASELAVAQQKEKEL 136
                        ...|:..|:.....|.||   |:.|....||.|:..   .::|........:|
Human   576 ------------EEKFESRLEDSCVEKLKTRSSDMSDGSDFEDVNTTT---GTDLDTTTGTGSDL 625

  Fly   137 NNNHIAASLADLGFDMSRKMLRALREGGAGGGGGGGGGGGGGGGPPNAP------PL-------- 187
            :        :|:..|..       ::.|.|....|....|||..||.||      |:        
Human   626 D--------SDVDSDPD-------KDKGKGKSAEGQPKFGGGLAPPGAPNSVAEVPVFYSQHSFF 675

  Fly   188 TPPQ-----------CSIPAV--------HPTLLEAMTKNL-PLQYRNVFA-GVLPG-------- 223
            .||.           .||.|:        .|..:....|.| .|.|.:.|. ..||.        
Human   676 PPPDEQLLTATGAAGDSIKAIASIAEKYFGPGFMGMQEKKLGSLPYHSAFPFQFLPNFPHSLYPF 740

  Fly   224 ----------------------KVNSPAA-----------------------SSSPTGADFPF-- 241
                                  ||..|:|                       |:..:|.:.|.  
Human   741 TDRALAHNLLVKAEPKSPRDALKVGGPSAECPFDLTTKPKDVKPILPMPKGPSAPASGEEQPLDL 805

  Fly   242 --------------RHPLKK-----------------CELTWPPPTEQLQLELPHPNP------- 268
                          |.|.|.                 |....|   :|..|....|:|       
Human   806 SIGSRARASQNGGGREPRKNHVYGERKLGAGEGLPQVCPARMP---QQPPLHYAKPSPFFMDPIY 867

  Fly   269 --------------------KLSPVLPHPQLQDYQT---RRKNKARTAATGGNATPNLP------ 304
                                :.||:|.|||:...:|   :.::.|...|..|::...||      
Human   868 SRVEKRKVTDPVGALKEKYLRPSPLLFHPQMSAIETMTEKLESFAAMKADSGSSLQPLPHHPFNF 932

  Fly   305 ------------QRNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKYCERSFSISSNLQRH 357
                        ::.|:||||::|||:||||||||||||||||||||:||||:||||||||||||
Human   933 RSPPPTLSDPILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQRH 997

  Fly   358 VRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESDAVSLSALSGVSERMHCIRRFCENPT---- 418
            ||||||||:||||.:|.|||||||||||||||||.:...:|...||... | :.....:||    
Human   998 VRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENAPVSQHPGVLTN-H-LGTSASSPTSESD 1060

  Fly   419 --------EESYFEEIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSSCS---------- 465
                    |:|||.|||:|:......|...:.:::.|.|       ....|:.|.          
Human  1061 NHALLDEKEDSYFSEIRNFIANSEMNQASTRTEKRADMQ-------IVDGSAQCPGLASEKQEDV 1118

  Fly   466 SSRDTPTSSHEEADHAPATSTADTAAPS---SSRDQEEEDSQPIMEL 509
            ...|......::.|.....|..||.:|:   .:..::|||.:|...|
Human  1119 EEEDDDDLEEDDEDSLAGKSQDDTVSPAPEPQAAYEDEEDEEPAASL 1165

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG10348NP_609904.2 zf-C2H2 311..333 CDD:395048 18/21 (86%)
C2H2 Zn finger 313..333 CDD:275368 16/19 (84%)
zf-H2C2_2 325..349 CDD:463886 21/23 (91%)
C2H2 Zn finger 341..362 CDD:275368 19/20 (95%)
zf-C2H2 368..390 CDD:395048 18/21 (86%)
C2H2 Zn finger 370..390 CDD:275368 16/19 (84%)
PRDM16NP_071397.3 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1..68
PR-SET_PRDM16 61..222 CDD:380990
zf-C2H2 281..303 CDD:395048
C2H2 Zn finger 283..303 CDD:275368
zf-H2C2_2 295..319 CDD:463886
zf-C2H2 309..331 CDD:395048
C2H2 Zn finger 311..331 CDD:275368
COG5048 <335..492 CDD:227381
C2H2 Zn finger 339..357 CDD:275368
C2H2 Zn finger 368..388 CDD:275368
zf-C2H2 394..416 CDD:395048
C2H2 Zn finger 396..416 CDD:275368
C2H2 Zn finger 425..443 CDD:275368
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 533..657 31/164 (19%)
Interaction with CTBP1, CTBP2 and ZNF516. /evidence=ECO:0000250|UniProtKB:A2A935 679..1038 113/361 (31%)
Mediates interaction with SKI and regulation of TGF-beta signaling. /evidence=ECO:0000269|PubMed:19049980 739..1276 132/439 (30%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 772..804 3/31 (10%)
COG5048 931..>1083 CDD:227381 88/153 (58%)
zf-C2H2 951..973 CDD:395048 18/21 (86%)
C2H2 Zn finger 953..973 CDD:275368 16/19 (84%)
zf-H2C2_2 965..989 CDD:463886 21/23 (91%)
C2H2 Zn finger 981..1002 CDD:275368 19/20 (95%)
C2H2 Zn finger 1010..1030 CDD:275368 16/19 (84%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1033..1065 6/33 (18%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 1105..1163 11/57 (19%)
Blue background indicates that the domain is not in the aligned region.

Return to query results.
Submit another query.