DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG10348 and prdm16

DIOPT Version :9

Sequence 1:	NP_001286059.1	Gene:	CG10348 / 35132	FlyBaseID:	FBgn0032707	Length:	540	Species:	Drosophila melanogaster
Sequence 2:	XP_031761546.1	Gene:	prdm16 / 100485690	XenbaseID:	XB-GENE-991670	Length:	1307	Species:	Xenopus tropicalis

Alignment Length:	570	Identity:	175/570 - (30%)
Similarity:	239/570 - (41%)	Gaps:	183/570 - (32%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MREKD------HS--PRKMLPS-PKQGCVYPAL-------GLI----PTSYISHVPYDLASSASV 45
            |:||.      ||  |.:.||: |..  :|||.       .|:    |.|     |.||   ..|
Frog   742 MQEKKMGSLPYHSMFPFQFLPNFPHS--LYPAFTDRTMNHNLLVKAEPKS-----PRDL---QKV 796

  Fly    46 AATSSSSTSPTTT------SATTTGRLQHQHSHQQHQTLNHHAKGKRRSSFDQPLDLRLAHKRKT 104
            .:|||.|....||      ||....|:....|                |..:|||||.::::.:
Frog   797 GSTSSESPFDLTTKPKEIKSALIPPRVLAPQS----------------SGEEQPLDLSISNRSR- 844

  Fly   105 DLVDQGPMEDENSNLIMFASELAVAQQKEKELNNNHIAASLADLGFDMSRKMLRALREGGAGGGG 169
                                   .:|...:|...|||.:....:..||..|:
Frog   845 -----------------------ASQNGARETRRNHIYSDRKMMMNDMLSKI------------- 873

  Fly   170 GGGGGGGGGGGPPNAPPLTPPQCSIPAVHPTLLEAMTKNLPLQYRNVFAGVLPGKVNSPAASSSP 234
                                ||..:|           :..||.|                |..||
Frog   874 --------------------PQSQLP-----------QQPPLHY----------------AKPSP 891

  Fly   235 TGADFPFRHPLKKCELTWPPPTEQLQLELPHPNPKLSPVLPHPQ---LQDYQTRRKNKARTAATG 296
            ...| |....::|.::|.|..|.:.:...|      ||:|.|||   :::...:.:|.|...|..
Frog   892 FFMD-PIYSRVEKRKVTDPVGTMKEKYLRP------SPLLFHPQMSAIENMTEKLENFANLKADT 949

  Fly   297 GNATPNLP------------------QRNKDRYTCKFCGKVFPRSANLTRHLRTHTGEQPYKCKY 343
            |::...||                  ::.|:||||::|||:||||||||||||||||||||:|||
Frog   950 GSSLQPLPHHPFNFRSPPTTLSDSILRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKY 1014

  Fly   344 CERSFSISSNLQRHVRNIHNKERPFKCEICERCFGQQTNLDRHLKKHESDAVSLSALSGVSERMH 408
            |:||||||||||||||||||||:||||.:|.|||||||||||||||||.:.|.:|..|||....|
Frog  1015 CDRSFSISSNLQRHVRNIHNKEKPFKCHLCNRCFGQQTNLDRHLKKHEHENVPVSQHSGVITNHH 1079

  Fly   409 CIRRFCEN----------PTEESYFEEIRSFMGKVTQQQQQQQQQQQHDQQQQQHQSTATSASSS 463
            .......|          ..|:|||.|||:|:.. ::..|.....::..:.|....|...|..:.
Frog  1080 GTSVSSPNSESENHALLDEKEDSYFSEIRNFIAN-SELNQTASLAEKRTEIQDIDSSKCLSLVNQ 1143

  Fly   464 CSSSRDTPTSSHEEADHAPATSTA----DTAAPS----SSRDQEEEDSQP 505
            .....|.......|.|:...:.|.    :|.:||    .:.:::|||.:|
Frog  1144 KPDDADEEEDDELEEDYEDGSLTGKSQDETVSPSMENQETYEEDEEDEEP 1193

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG10348	NP_001286059.1	COG5048	300..>363	CDD:227381	50/80 (63%)
		zf-C2H2	311..333	CDD:278523	18/21 (86%)
		C2H2 Zn finger	313..333	CDD:275368	16/19 (84%)
		zf-H2C2_2	325..349	CDD:290200	21/23 (91%)
		C2H2 Zn finger	341..362	CDD:275368	19/20 (95%)
		zf-H2C2_2	353..377	CDD:290200	19/23 (83%)
		zf-C2H2	368..390	CDD:278523	18/21 (86%)
		C2H2 Zn finger	370..390	CDD:275368	16/19 (84%)
prdm16	XP_031761546.1	SET	61..222	CDD:394802
		C2H2 Zn finger	232..258	CDD:275368
		zf-C2H2	278..300	CDD:395048
		C2H2 Zn finger	280..300	CDD:275368
		zf-H2C2_2	292..316	CDD:404364
		C2H2 Zn finger	308..328	CDD:275368
		C2H2 Zn finger	336..387	CDD:275368
		zf-C2H2	396..418	CDD:395048
		C2H2 Zn finger	398..418	CDD:275368
		C2H2 Zn finger	426..449	CDD:275368
		C2H2 Zn finger	458..476	CDD:275368
		zf-C2H2	982..1004	CDD:395048	18/21 (86%)
		C2H2 Zn finger	984..1004	CDD:275368	16/19 (84%)
		zf-H2C2_2	996..1020	CDD:404364	21/23 (91%)
		SUF4-like	1012..>1067	CDD:411020	46/54 (85%)
		C2H2 Zn finger	1012..1038	CDD:411020	24/25 (96%)
		C2H2 Zn finger	1012..1033	CDD:275368	19/20 (95%)
		C2H2 Zn finger	1041..1062	CDD:411020	17/20 (85%)
		C2H2 Zn finger	1041..1061	CDD:275368	16/19 (84%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	54	1.000	Domainoid score	I11069
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D254483at33208
OrthoFinder	1	1.000	-	-		FOG0002720
OrthoInspector	1	1.000	-	-		otm47956
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	4.010