DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment SPH93 and CG1299

DIOPT Version :9

Sequence 1:	NP_609840.1	Gene:	SPH93 / 35049	FlyBaseID:	FBgn0032638	Length:	494	Species:	Drosophila melanogaster
Sequence 2:	NP_647862.1	Gene:	CG1299 / 38496	FlyBaseID:	FBgn0035501	Length:	511	Species:	Drosophila melanogaster

Alignment Length:	519	Identity:	122/519 - (23%)
Similarity:	199/519 - (38%)	Gaps:	113/519 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    24 TCVTRNFC-----LYEEPTFD--------------YRSSNCGNTKICCAVLRK------------ 57
            :||...:|     :::..:.|              .||.| |:..|||...|.
  Fly    46 SCVALTYCPQVVNIFQTTSRDRAQRYVIALQRSCGTRSIN-GDPVICCTEPRYNPVTERPRNPFF 109

  Fly    58 PGGTVLIEPNGPED--DKVGVNGINAQLSPTRELTRDRPNTIESQVKEINDFSGRPTNNERNPAT 120
            |..:..|.|..|.:  |       |..|.||...|.....|..:.:.:          ....|..
  Fly   110 PSESTFIGPQPPPEVPD-------NPFLIPTPRTTTTTTTTTPAPIPD----------TSAAPLI 157

  Fly   121 EPN----NGGYTTPNGGYPVNNGGYPVNNGGYPSNNGGYPSNNGGYPVNNGGYPVNNGGYPANNG 181
            ||.    .|..|.|.....:......:|.....|.:..:                  ..:...:.
  Fly   158 EPRGTVCRGPDTKPGNCVEIKECASLLNELRSRSQDATF------------------ANFLRASN 204

  Fly   182 GYPANNGGYPTTNVGNPTNNGGNPTTNFGN---PTNNGGNPTTNVGSSELLSPSCGMSNANGLQM 243
            ....|.|    |.|..||..|...||...:   |.|....|...:...|    .||.:.....::
  Fly   205 AVCQNKG----TQVCCPTGQGITNTTPAPSQIVPKNTDEIPRRLLNVEE----GCGSTVGYFKKI 261

  Fly   244 VEGITIDQARPAQYPWAVAIFHN----GQYLAGGSLIQPNVVLTVAHRVITIETEL-VVRAGDWD 303
            |.|   :.:|...:||...:.::    ..:..||:||....|||.||   .|..:| .||.|:.|
  Fly   262 VGG---EVSRKGAWPWIALLGYDDPSGSPFKCGGTLITARHVLTAAH---CIRQDLQFVRLGEHD 320

  Fly   304 LKSDRE---IFLSEQREVERAVIHEGFDFKSGANNLALLFLNSPFKLNDHIRTICLP-TPN---K 361
            |.:|.|   :.::    :.|.|.|..::.::|.:::|:|:|....:....|..|||| |.|   |
  Fly   321 LSTDTETGHVDIN----IARYVSHPDYNRRNGRSDMAILYLERNVEFTSKIAPICLPHTANLRQK 381

  Fly   362 SFAGRRCTVAGWGKMRYEDQRYSTVLKKVQLLVVNRNVC-EKFLRSTRLGAKFELPKNIICAG-- 423
            |:.|....|||||| ..|....:.||.::|:.:.:..|| :.:.:..|..:..:..|.::|||
  Fly   382 SYVGYMPFVAGWGK-TMEGGESAQVLNELQIPIYDNKVCVQSYAKEKRYFSADQFDKAVLCAGVL 445

  Fly   424 -GELGRDTCTGDGGSALFCSIGGENSGVYEQAGIVNWGVGCGQEGIPAIYTEVSKFTNWITEKL 486
             |  |:|||.||.|..|......:....:...|:|::|:||.:..:|.:|:....|.:||.:::
  Fly   446 SG--GKDTCQGDSGGPLMLPEPYQGQLRFYLIGVVSYGIGCARPNVPGVYSSTQYFMDWIIQQV 507

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SPH93	NP_609840.1	GRP	<136..189	CDD:254089	3/52 (6%)
		Tryp_SPc	250..485	CDD:238113	74/250 (30%)
		Tryp_SPc	252..482	CDD:214473	72/245 (29%)
CG1299	NP_647862.1	CLIP	37..93	CDD:197829	10/47 (21%)
		CLIP	164..216	CDD:288855	9/73 (12%)
		Tryp_SPc	260..503	CDD:214473	74/255 (29%)
		Tryp_SPc	261..503	CDD:238113	74/254 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910