Protein Alignment CG12620 and PPP1R2C

DIOPT Version :10

• Sequence 1: NP_609828.2
• Gene: CG12620 / 35034
• FlyBaseID: FBgn0032626
• Length: 287
• Species: Drosophila melanogaster
• Sequence 2: NP_079486.1
• Gene: PPP1R2C / 80316
• HGNCID: 16324
• Length: 202
• Species: Homo sapiens
• Alignment Length: 156
• Identity: 43/156 - (27%)
• Similarity: 67/156 - (42%)
• Gaps: 32/156 - (20%)

  Fly     8 FDKMNLGVPVHSDPY-EVENESASSIKRETGE---KVMSHKELMEKLHKEVKLTTPDFFAHDPSC 68
            :|.|....|..|  | .|::....|::...||   :.:..||..:              |.|.||
Human    63 YDLMKANEPGTS--YMSVQDNGEDSVRDVEGEDSVRGVEGKEATD--------------ASDHSC 111

  Fly    69 SSDDSEDFE-FLETI---KERARRISFVRRRKLHYTEFSTVELARRL----IREEFTESSESQLS 125
            ..|:.|..| ::..|   |:..:| .|..||:|||.|...::|||:|    ::.|..|:.|:...
Human   112 EVDEQESSEAYMRKILLHKQEKKR-QFEMRRRLHYNEELNIKLARQLMWKELQSEDNENEETPQG 175

  Fly   126 VDDEHISEIAEEECPPCG---TDSDD 148
            .::|..:....||.|..|   |.|.|
Human   176 TNEEKTAAEESEEAPLTGGLQTQSCD 201

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG12620	NP_609828.2	IPP-2	<18..115	CDD:461504	29/108 (27%)
PPP1R2C	NP_079486.1	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..51
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55
		IPP-2	45..170	CDD:461504	34/123 (28%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	71..118		14/62 (23%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	144..147		2/2 (100%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	162..202		11/40 (28%)