DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12620 and PPP1R2C

DIOPT Version :9

Sequence 1:	NP_001260525.1	Gene:	CG12620 / 35034	FlyBaseID:	FBgn0032626	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_079486.1	Gene:	PPP1R2C / 80316	HGNCID:	16324	Length:	202	Species:	Homo sapiens

Alignment Length:	156	Identity:	43/156 - (27%)
Similarity:	67/156 - (42%)	Gaps:	32/156 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     8 FDKMNLGVPVHSDPY-EVENESASSIKRETGE---KVMSHKELMEKLHKEVKLTTPDFFAHDPSC 68
            :|.|....|..|  | .|::....|::...||   :.:..||..:              |.|.||
Human    63 YDLMKANEPGTS--YMSVQDNGEDSVRDVEGEDSVRGVEGKEATD--------------ASDHSC 111

  Fly    69 SSDDSEDFE-FLETI---KERARRISFVRRRKLHYTEFSTVELARRL----IREEFTESSESQLS 125
            ..|:.|..| ::..|   |:..:| .|..||:|||.|...::|||:|    ::.|..|:.|:...
Human   112 EVDEQESSEAYMRKILLHKQEKKR-QFEMRRRLHYNEELNIKLARQLMWKELQSEDNENEETPQG 175

  Fly   126 VDDEHISEIAEEECPPCG---TDSDD 148
            .::|..:....||.|..|   |.|.|
Human   176 TNEEKTAAEESEEAPLTGGLQTQSCD 201

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12620	NP_001260525.1	IPP-2	<21..111	CDD:282789	27/97 (28%)
PPP1R2C	NP_079486.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..51
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55
		IPP-2	45..170	CDD:309902	34/123 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	71..118		14/62 (23%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	144..147		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	162..202		11/40 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165151817
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1321970at2759
OrthoFinder	1	1.000	-	-		FOG0003529
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12398
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	4.950