DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG12620 and Ppp1r2

DIOPT Version :9

Sequence 1:	NP_001260525.1	Gene:	CG12620 / 35034	FlyBaseID:	FBgn0032626	Length:	287	Species:	Drosophila melanogaster
Sequence 2:	NP_620178.1	Gene:	Ppp1r2 / 192361	RGDID:	621099	Length:	205	Species:	Rattus norvegicus

Alignment Length:	172	Identity:	44/172 - (25%)
Similarity:	74/172 - (43%)	Gaps:	36/172 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MTTKRTRFDKMNLGVPVH--------------SDPYE---VENESASSIKRETGEKVMSHKELME 48
            ::.|..::|:||:....|              ..||.   .::|...|  ...|.:||:.:.|.:
  Rat    40 LSKKSQKWDEMNILATYHPADKDYGLMKIDEPDTPYHNMIGDDEDVCS--DSEGNEVMTPEILAK 102

  Fly    49 KLHKEVKLTTPDFFAHDPSCSSDDSEDFEFLETIKERARRISFVRRRKLHYTEFSTVELARRLIR 113
            || ...:.:.|.|...:...|.::..|.    :.:||.::..|..:|||||.|...::|||:||.
  Rat   103 KL-AAAEGSEPKFRTREQESSGEEDNDL----SPEEREKKRQFEMKRKLHYNEGLNIKLARQLIS 162

  Fly   114 EEFTESSESQLSVDDEHISEIAE------EECPPCGTDSDDL 149
            ::..:..|      ||.:||.|:      ||.....|..|.|
  Rat   163 KDLHDDDE------DEEMSETADADSMNIEESNQGSTAGDHL 198

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG12620	NP_001260525.1	IPP-2	<21..111	CDD:282789	26/92 (28%)
Ppp1r2	NP_620178.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..44		0/3 (0%)
		Required for binding PPP1CC. /evidence=ECO:0000250	12..17
		Required for binding PPP1CC. /evidence=ECO:0000250	43..55		4/11 (36%)
		IPP-2	45..163	CDD:282789	32/124 (26%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	104..142		8/42 (19%)
		Required for binding PPP1CC catalytic center, displacing metal ions and inhibition of PPP1CC catalytic activity. /evidence=ECO:0000250	147..150		2/2 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	163..205		11/42 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG4041
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1321970at2759
OrthoFinder	1	1.000	-	-		FOG0003529
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR12398
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	6	5.880