Protein Alignment Cse1 and xpo-2

DIOPT Version :10

• Sequence 1: NP_523588.2
• Gene: Cse1 / 35016
• FlyBaseID: FBgn0022213
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_490716.1
• Gene: xpo-2 / 171621
• WormBaseID: WBGene00002079
• Length: 938
• Species: Caenorhabditis elegans
• Alignment Length: 993
• Identity: 289/993 - (29%)
• Similarity: 507/993 - (51%)
• Gaps: 90/993 - (9%)

  Fly     8 LQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLI--DKAQMDMTTRVAGAIAFKNY 70
            ::.:...|||||..|..:|:..|:.|.|.:....|.|.:|.|:  ::.|:....|:|.|:|.||:
 Worm     1 MEQIGAALQQTLEPDAAIRKRGEEALRSLQSNPGYIIQILQLVVNEQQQIAPQIRIAAAVALKNF 65

  Fly    71 IKRNWAAHLDSDGPD---RIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKWPQ 132
            :||||       ||.   .:.:.|....:::::..|.::...:|:.||:|:.:|.:.|||:|||.
 Worm    66 VKRNW-------GPAPEVEMGQEDEEQFRSMLLEAMFNTKSNVQEILSNALYLIAQRDFPEKWPD 123

  Fly   133 LIDEMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVLDRMAKPLTDLLQATMQL 197
            |:..:.:.....|.|.:...|.:...:|:::|:|.||..||:|:|..|....:|||.||:..|::
 Worm   124 LVPYLSKFLNGADLNHLVASLASMEQIFRKFRFESKSAELWKELKKCLLSTQEPLTLLLRNMMEV 188

  Fly   198 TKVHENNAGA------LKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSL 256
            .: .::..||      |:|    |:|:.||:.||.||::||:|||::..||..|:..:..|.|:
 Worm   189 GQ-RKDQLGADEIAQWLRV----LLLIAKVYHSLCSQEIPEYFEDHLKDWMPHFLHLVQIDAPT- 247

  Fly   257 RTADDEDAGVLEHLRAQVCENICLYAKKYDEEFKPFMEQFVTAVWELLVKTSLHTKYDSLVSHAL 321
            :|::..:...|:.|:.::||...||:::|:||...|:...:.|||.||..|...|:||::|..||
 Worm   248 QTSNSGEPTTLDELKHEICEIFTLYSQRYEEEISEFVPDIILAVWNLLKSTGPDTRYDTMVCAAL 312

  Fly   322 QFLSVVADRQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRR 386
            :|||:|:.||:|:..|....:|..:.:.|.:.||.:|..|.|:|||.|.:|::|||||:|:.|||
 Worm   313 EFLSMVSQRQYYEGHFTGEGVLKTLAENVCVQNLLLRQQDMELFEDEPLDYMKRDIEGTDVGTRR 377

  Fly   387 RAACDLVKTLSINFEQKIFGIFGQYLERLLTKYKENPATNWRSKDTAIYLVTSWASRGGTQKHGI 451
            |.|.||.:.|...||.::....|:.::.||      .:.:|...|....|:|:.|.:..|.|.|:
 Worm   378 RGAIDLARGLCRRFEAQMLPCLGEIVQNLL------GSGDWIKIDIVYSLITAIAVKTETAKSGV 436

  Fly   452 TQTSELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYVMVFRSILGPQVLASCLPQLIRHLPA 516
            |.|:.||.:.:|...|:...| ..::|:.|:|||.|:|:.:.||..|.|:.|.:.:......|.:
 Worm   437 TATNPLVDINDFFITQVATHL-NADVNQTPILKADALKFAVTFRKQLAPEHLMTAIKSADALLSS 500

  Fly   517 ESSVVHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENE-YVMKAIM 580
            .:.::|.|||.::|||| :.|::.  :|..|.|.  .:.::..|..........:|. |::|||:
 Worm   501 NTPILHKYAAYAIEKIL-LADSNK--IFSAQNLP--VSSILQNLVTAFDKDAKAQNSPYLIKAIL 560

  Fly   581 RSFSVLQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEE 645
            |...:|....:........:|.:::....|||:.....|:||||  :|:.|.  ...:..:|.:.
 Worm   561 RIIVILDDDTIRHADAIAVKLAQLVESATKNPADSVHTHFLFET--ICVLIT--KTRTIGASLDA 621

  Fly   646 ALFPVFQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLI 710
            .|.|:.:.|.::|:.:.:||..|:..||:.......:..:.:....|.|||..||.|:.||...:
 Worm   622 QLLPLIEVIFREDLEDLIPYALQITGVLVSSCIARNSSIDQFSPFLPFLLSERLWARSANVPAAL 686

  Fly   711 RLISAFIKQGSAQIQALGKLSG-ILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIF 774
            .::...:...:.::  :.:.|| ||....:::.||..|..||.|...:|   |..|........|
 Worm   687 SVLEVILSVNAQRV--VSENSGLILSHLARLLGSKTLDQYGFQLAATIL---PSIEHFEGSAMTF 746

  Fly   775 GL--LFQRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIP 837
            .|  :|:|:..|||||::...|:|...:.|..|...:.|..:.||..:||||:::|...::..:.
 Worm   747 VLNTMFRRVQSSKTPKFMKLFIVFLCRFTIARSAQDLVQSCENIQTGMFGMLIEKVVCIDLPGLK 811

  Fly   838 KE---QDRKMVAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFE----------RPPEKLMGL 889
            :.   .:::::|:|:..||.:..:.|..||..    |.:.:..|.|          .|.|:...:
 Worm   812 QTTTGPEKRIIAIGMGNLLADVTQQLVGQYGI----LSYEVAMLLEAASASDRAVLSPEEEQASM 872

  Fly   890 EIGETAGVAEDPDAGYQVAFAQLTHAQPNQQDHLAEIKDARQFLATSLSKFAQA----RAGEFST 950
            ...|  |...:|       |.:|::| |.|....|.|.:.:.:       ||||    ..|....
 Worm   873 YNAE--GEFVNP-------FCRLSYA-PKQPPVAANIANHKAY-------FAQAVLVRGPGNCPE 920

  Fly   951 LLSPLEPE---YKQVLQK 965
            .|..:.||   |.|.:|:
 Worm   921 TLRSVPPEIVTYLQSIQQ 938

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:397745	22/80 (28%)
		Cse1	159..529	CDD:430038	132/375 (35%)
		CAS_CSE1	530..966	CDD:367469	113/460 (25%)
xpo-2	NP_490716.1	CSE1	3..799	CDD:227944	254/829 (31%)
		Cse1	150..513	CDD:430038	132/375 (35%)