Protein Alignment Cse1 and Cse1l

DIOPT Version :10

• Sequence 1: NP_523588.2
• Gene: Cse1 / 35016
• FlyBaseID: FBgn0022213
• Length: 975
• Species: Drosophila melanogaster
• Sequence 2: NP_076054.1
• Gene: Cse1l / 110750
• MGIID: 1339951
• Length: 971
• Species: Mus musculus
• Alignment Length: 983
• Identity: 507/983 - (51%)
• Similarity: 692/983 - (70%)
• Gaps: 22/983 - (2%)

  Fly     1 MEVTEANLQLLAGYLQQTLSADPNVRRPAEKLLESTELQQNYPILLLNLIDKAQMDMTTRVAGAI 65
            ||:::||||.|..||::||..||.:||||||.|||.|..||||:|||.|::|:| |...:|..::
Mouse     1 MELSDANLQTLTEYLKKTLDPDPAIRRPAEKFLESVEGNQNYPLLLLTLLEKSQ-DNVIKVCASV 64

  Fly    66 AFKNYIKRNWAAHLDSDGPDRIHESDRNTIKTLIVTLMLHSPVALQKQLSDAVSIIGKYDFPKKW 130
            .|||||||||  .:..|.|::|.|:||..||..||.|||.||..:|||||||:||||:.|||:||
Mouse    65 TFKNYIKRNW--RIVEDEPNKICEADRVAIKANIVHLMLSSPEQIQKQLSDAISIIGREDFPQKW 127

  Fly   131 PQLIDEMVERFASGDFNVINGVLQTAHSLFKRYRYEFKSQALWEEIKFVLDRMAKPLTDLLQATM 195
            |.|:.|||.||.||||:||||||:||||||||||:||||..||.|||.|||..|.|||:|.:||:
Mouse   128 PDLLTEMVNRFQSGDFHVINGVLRTAHSLFKRYRHEFKSNELWTEIKLVLDAFALPLTNLFKATI 192

  Fly   196 QLTKVHENNAGALKVIYGSLVLVNKVFFSLNSQDLPEFFEDNINTWMGAFIQQLAADVPSLRTAD 260
            :|...|.|:|.||::::.||:|::|:|:|||.||||||||||:.|||..|...|..|...|:|.|
Mouse   193 ELCSTHANDASALRILFSSLILISKLFYSLNFQDLPEFFEDNMETWMNNFHTLLTLDNKLLQTDD 257

  Fly   261 DEDAGVLEHLRAQVCENICLYAKKYDEEFKPFMEQFVTAVWELLVKTSLHTKYDSLVSHALQFLS 325
            :|:||:||.|::|:|:|..|||:||||||:.::.:||||:|.|||.|....|||.|||:|:|||:
Mouse   258 EEEAGLLELLKSQICDNAALYAQKYDEEFQRYLPRFVTAIWNLLVTTGREVKYDLLVSNAIQFLA 322

  Fly   326 VVADRQHYQSIFENPEILAQICDKVVIPNLDIRPSDEEIFEDSPEEYIRRDIEGSDIDTRRRAAC 390
            .|.:|.||:::||:...|..||:||::||::.|.:|||.|||:.|||||||:|||||||||||||
Mouse   323 SVCERPHYKNLFEDQNTLTSICEKVIVPNMEFRAADEEAFEDNSEEYIRRDLEGSDIDTRRRAAC 387

  Fly   391 DLVKTLSINFEQKIFGIFGQYLERLLTKYKENPATNWRSKDTAIYLVTSWASRGGTQKHGITQTS 455
            |||:.|...||..:.|||..|:..:|.:|.:||:.||:.||.|||||||.||:..||||||||.:
Mouse   388 DLVRGLCKFFEGPVTGIFSGYVNSMLQEYAKNPSVNWKHKDAAIYLVTSLASKAQTQKHGITQAN 452

  Fly   456 ELVPLPEFCAQQIIPELERPNINEFPVLKAAAIKYVMVFRSILGPQVLASCLPQLIRHLPAESSV 520
            |||.|.||....|:|:|:..|:||||||||..|||:|:||:.:..:.|...:|.||.||.|||.|
Mouse   453 ELVNLTEFFVNHILPDLKSNNVNEFPVLKADGIKYIMIFRNQVPKEHLLVSIPLLISHLEAESIV 517

  Fly   521 VHSYAACSVEKILSMRDASNAIVFGPQILAPYTTELISGLFATLSLPGSGENEYVMKAIMRSFSV 585
            ||:|||.::|::.:||.::|..:|....:||:...|::.||..|:||||.||||:|||||||||:
Mouse   518 VHTYAAHALERLFTMRGSNNTTLFTAAEIAPFVEILLTNLFKALTLPGSSENEYIMKAIMRSFSL 582

  Fly   586 LQSAAMPFMGVALPRLTEILTQVAKNPSRPQFNHYLFETLALCIKIVCHADSSAVSSFEEALFPV 650
            ||.|.:|::...:.:||:.|..|:||||:|.||||:||.:.|.|:|.|.|:.:||.:||||||.|
Mouse   583 LQEAIIPYIPTLITQLTQKLLAVSKNPSKPHFNHYMFEAICLSIRITCKANPAAVVNFEEALFLV 647

  Fly   651 FQGILQQDIVEFMPYVFQMLSVLLEMREGTGTIPEPYWALFPCLLSPALWDRTGNVTPLIRLISA 715
            |..|||.|:.||:|||||::|:|||..:  ..||..|.||||.||.|.||:||||:..|:||:.|
Mouse   648 FTEILQNDVQEFIPYVFQVMSLLLETHK--NDIPSSYMALFPHLLQPVLWERTGNIPALVRLLQA 710

  Fly   716 FIKQGSAQI--QALGKLSGILGIFQKMIASKANDHEGFYLLQNLLSYYPPAEIQTNLRQIFGLLF 778
            |:::||:.|  .|..|:.|:||:|||:||||||||:|||||.:::.:.||..:....:|||.|||
Mouse   711 FLERGSSTIATAAADKIPGLLGVFQKLIASKANDHQGFYLLNSIIEHMPPESVDQYRKQIFILLF 775

  Fly   779 QRLSLSKTPKYLSGIIIFFSFYVIKFSGSQMAQLIDEIQPNLFGMLLDRVFITEMGKIPKEQDRK 843
            |||..|||.|::...::|.:.|.||:....:.::.|.|||.:|||:|:::.|.|:.|:....::|
Mouse   776 QRLQNSKTTKFIKSFLVFINLYCIKYGALALQEIFDGIQPKMFGMVLEKIIIPEIQKVSGNVEKK 840

  Fly   844 MVAVGVTKLLTETPEILQQQYATFWPRLLHSLIDLFERP-----PEKLMGLEIGETAGVAEDPDA 903
            :.|||:||||||.|.::..:|...|..||.|||.|||.|     |::...::|.:|        .
Mouse   841 ICAVGITKLLTECPPMMDTEYTKLWTPLLQSLIGLFELPEDDSIPDEEHFIDIEDT--------P 897

  Fly   904 GYQVAFAQLTHAQPNQQDHLAE-IKDARQFLATSLSKFAQARAGEFSTLLS-PLEPEYKQVLQKY 966
            |||.||:||..|...:.|.:.: :.:.:..||.||.|.:.|..|...:::| .|..|..|.||.|
Mouse   898 GYQTAFSQLAFAGKKEHDPVGQMVNNPKIHLAQSLHKLSTACPGRVPSMVSTSLNAEALQYLQGY 962

  Fly   967 CDQAGVRI 974
            ...|.|.:
Mouse   963 LQAASVTL 970

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Cse1	NP_523588.2	IBN_N	29..105	CDD:397745	40/75 (53%)
		Cse1	159..529	CDD:430038	209/369 (57%)
		CAS_CSE1	530..966	CDD:367469	199/444 (45%)
Cse1l	NP_076054.1	IBN_N	29..102	CDD:197981	40/75 (53%)
		Cse1	156..526	CDD:430038	209/369 (57%)
		CAS_CSE1	527..962	CDD:367469	199/444 (45%)