DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment her and Zfp341

DIOPT Version :9

Sequence 1:	NP_001260506.1	Gene:	her / 34992	FlyBaseID:	FBgn0001185	Length:	487	Species:	Drosophila melanogaster
Sequence 2:	NP_955008.2	Gene:	Zfp341 / 228807	MGIID:	2682937	Length:	846	Species:	Mus musculus

Alignment Length:	258	Identity:	62/258 - (24%)
Similarity:	102/258 - (39%)	Gaps:	67/258 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 SAWKFRCSVDRCPYRTNRPYNLARHEESHIGITQSKLYGCPVCVYNTDKASNLKRHVSIKHPGCK 81
            |..:|||.:  |.....:.:.|..|...|.|   .|.|.|.||....::...||||:.|..|..|
Mouse   587 SGGRFRCQI--CKKFFRKEHYLKLHAHIHSG---EKPYKCSVCESAFNRKDKLKRHMLIHEPFKK 646

  Fly    82 KRPPEAQHKDRNAKLQCLVMGCRYETNRPYDLKRHLMVHNNPEKSHRTFKCSLCTYSSDRKANLK 146
            .:.|.:.|           .||..|.||...||.|::.|.. .|.|   ||.||:.|..|:|:|.
Mouse   647 YKCPFSMH-----------TGCSKEFNRQDKLKAHILSHAG-LKLH---KCGLCSKSFSRRAHLA 696

  Fly   147 RH-------HELRHSGIEEAIQTAEELRQEMLLEKQMLKEHKLKYQITEKQDLKNLKLKDQKQKV 204
            .|       ::.|.:|..:...           ..:.||:|:.:...|:.:||:
Mouse   697 EHQRAHTGNYKFRCAGCAKGFS-----------RHKYLKDHRCRLGPTKDKDLQ----------- 739

  Fly   205 QMLRDQQPKQR------------QKKEQLLEDQSPVLNKQLEHGNIPLKEALVGSMKYDEESL 255
               ..:.|::|            .|:|..:.|  |:..::|:... |..||..|...::::::
Mouse   740 ---ARRPPRRRATARGGGSIASGHKEENPMPD--PLGLEELKAAG-PSPEAAPGKPPFEQDAV 796

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
her	NP_001260506.1	C2H2 Zn finger	23..45	CDD:275368	4/21 (19%)
		C2H2 Zn finger	56..77	CDD:275368	8/20 (40%)
		C2H2 Zn finger	98..120	CDD:275368	8/21 (38%)
		C2H2 Zn finger	132..149	CDD:275370	8/23 (35%)
		tolA	140..>220	CDD:236545	15/98 (15%)
Zfp341	NP_955008.2	COG5048	321..726	CDD:227381	47/169 (28%)
		zf-C2H2	321..342	CDD:278523
		C2H2 Zn finger	322..342	CDD:275368
		zf-H2C2_2	334..359	CDD:290200
		C2H2 Zn finger	350..370	CDD:275368
		C2H2 Zn finger	444..464	CDD:275368
		C2H2 Zn finger	472..494	CDD:275368
		C2H2 Zn finger	502..522	CDD:275368
		C2H2 Zn finger	539..561	CDD:275370
		C2H2 Zn finger	565..585	CDD:275368
		C2H2 Zn finger	593..613	CDD:275368	4/21 (19%)
		zf-H2C2_2	605..630	CDD:290200	9/27 (33%)
		C2H2 Zn finger	621..641	CDD:275368	7/19 (37%)
		C2H2 Zn finger	649..674	CDD:275368	10/35 (29%)
		C2H2 Zn finger	682..702	CDD:275368	8/19 (42%)
		C2H2 Zn finger	710..727	CDD:275368	3/27 (11%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910