Protein Alignment CG5888 and LRRC52

DIOPT Version :8

• Sequence 1: NP_001285981.1
• Gene: CG5888 / 34980
• FlyBaseID: FBgn0028523
• Length: 455
• Species: Drosophila melanogaster
• Sequence 2: NP_001005214.2
• Gene: LRRC52 / 440699
• HGNCID: 32156
• Length: 313
• Species: Homo sapiens
• Alignment Length: 421
• Identity: 80/422 (19%)
• Similarity: 146/422 (35%)
• Gaps: 143/422 (34%)

  Fly    37 KEPNLCECQEQEIKCENLQLHSDNLQLYGISCSIFDARGF------GYIPPLKVGNIGSLIVQNC 95
            |.||.|.||.||:.|...||..     |.:...:...|.|      ..:|.:.:|.:..|:..:|
Human    25 KCPNNCLCQAQEVICTGKQLTE-----YPLDIPLNTRRLFLNENRITSLPAMHLGLLSDLVYLDC 84

  Fly    96 AIPNAESIKYLLSKLGVSNYTELEIFNYFDPKKTDRGEVLQQHYTDHESLKKVSIIGFKSTLPEN 160
            .......         |.:||.:.:|...              |.|..|....||..|..::..|
Human    85 QNNRIRE---------VMDYTFIGVFKLI--------------YLDLSSNNLTSISPFTFSVLSN 126

  Fly   161 FLENLPALQQLSLKGSSDLPGNILHPLKNLTHLEIVVKNLGKVSGAIFAKQSKLKHLMIDCDAKN 225
                   |.||:              :.|..||    .:|.|.:   ||..:.|::|    |.:|
Human   127 -------LVQLN--------------IANNPHL----LSLHKFT---FANTTSLRYL----DLRN 159

  Fly   226 SSVEMSAFGPQELWHMTELQSIELFNCGDNVPTELFWMSEQLAYIGIRSNISYLSKDFLKVQKKL 290
            :.::  ......|:|:|.|::  ||..|:.      |          :.|.|:|  ||...   |
Human   160 TGLQ--TLDSAALYHLTTLET--LFLSGNP------W----------KCNCSFL--DFAIF---L 199

  Fly   291 LTLRLERNNIARLPDQLFRNTPLILEIHLAFNNLDRIQSGLFDKLKNLQVLNLEHNPITTIALNA 355
            :...::.:      |.|  |...:....|....:.|:.    :.|:.:.:.:|:|.....:.|..
Human   200 IVFHMDPS------DDL--NATCVEPTELTGWPITRVG----NPLRYMCITHLDHKDYIFLLLIG 252

  Fly   356 FTPIPTAHIYVGKLFKAAKNADWARSTNATICEEEYIYGVC--IYCKRDEYLDHFADSENCNKPN 418
            |.           :|.|...|.|             :.|||  :|    :...|.:..|:.::..
Human   253 FC-----------IFAAGTVAAW-------------LTGVCAVLY----QNTRHKSSEEDEDEAG 289

  Fly   419 PKAKDVLAKKAYENQLKAMPTHSWKKAKEYP 449
            .:.:  ::::.::.|..::        :|:|
Human   290 TRVE--VSRRIFQTQTSSV--------QEFP 310

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CG5888	NP_001285981.1	leucine-rich repeat	168..189	CDD:275380	3/21 (14%)
		leucine-rich repeat	190..213	CDD:275380	6/23 (26%)
		leucine-rich repeat	214..243	CDD:275380	7/29 (24%)
		leucine-rich repeat	244..266	CDD:275380	5/22 (23%)
		leucine-rich repeat	267..289	CDD:275380	5/22 (23%)
		LRR_8	288..348	CDD:290566	9/60 (15%)
		leucine-rich repeat	290..313	CDD:275380	4/23 (17%)
		leucine-rich repeat	314..337	CDD:275380	3/23 (13%)
		leucine-rich repeat	338..357	CDD:275380	4/19 (21%)
LRRC52	NP_001005214.2	NEL	<2..>93	CDD:330839	19/82 (23%)
		LRRNT	26..55	CDD:214470	11/34 (32%)
		leucine-rich repeat	35..54	CDD:275380	6/24 (25%)
		LRR 1	54..75		4/21 (19%)
		leucine-rich repeat	55..78	CDD:275380	4/23 (17%)
		LRR 2	78..99		5/30 (17%)
		LRR_8	79..136	CDD:316378	17/101 (17%)
		leucine-rich repeat	79..102	CDD:275380	6/32 (19%)
		LRR 3	102..123		6/35 (17%)
		leucine-rich repeat	103..126	CDD:275380	6/37 (16%)
		LRR_8	125..185	CDD:316378	22/96 (23%)
		LRR 4	126..148		11/50 (22%)
		leucine-rich repeat	127..151	CDD:275380	10/45 (22%)
		LRR 5	151..172		5/27 (19%)
		leucine-rich repeat	152..175	CDD:275380	7/29 (24%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100			LDO	PTHR46473
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	1.100