DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG4278 and Nif3l1

DIOPT Version :9

Sequence 1:	NP_609790.1	Gene:	CG4278 / 34970	FlyBaseID:	FBgn0014092	Length:	292	Species:	Drosophila melanogaster
Sequence 2:	NP_075364.2	Gene:	Nif3l1 / 65102	MGIID:	1929485	Length:	376	Species:	Mus musculus

Alignment Length:	349	Identity:	120/349 - (34%)
Similarity:	173/349 - (49%)	Gaps:	90/349 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 LAAVVKELENFAPTSWAEKWDNVGLLIEPHREKQIKKILLTNDLTEPVVKEALEKEAELIISYHP 77
            |.|::..|.:||..|:||.|||||||:||.....:..:.|||||||.|:.|||:|:|:.|:||||
Mouse    29 LKALLSSLNDFASLSFAESWDNVGLLVEPSPPHTVNTLFLTNDLTEEVMDEALQKKADFILSYHP 93

  Fly    78 PIFKPLTRITQSHWKERVVAACLANDIALYSPHTAWDKKSGGVNDWLSKAVNIISIRPLEPELGA 142
            |||:|:..||...|||.:|...|.|.:|:||||||:|....|||.||:|.:...:.||:.|. .|
Mouse    94 PIFRPMKHITWKTWKECLVIRALENRVAVYSPHTAYDAAPQGVNSWLAKGLGTCTTRPIHPS-RA 157

  Fly   143 P--------------------------------------PG------------------------ 145
            |                                      |.
Mouse   158 PDYPTEGAHRLEFSVNRSQDLDKVMSTLRGVGGVSVTSFPARCDGEEQTRISLNCTQKTLMQVLA 222

  Fly   146 ------------------------TGSGRY--IETKMELSQVVESLQKRIRNS-VHVALAVGHTP 183
                                    ||.||.  ::..:.|:.::|.::..::.| :.:||.||.|.
Mouse   223 FLSQDRQLYQKTEILSLEKPLLLHTGMGRLCTLDESVSLAIMIERIKTHLKLSHLRLALGVGRTL 287

  Fly   184 KTLIQSVGICAGSGASLLKGIQADLIITGEMSHHEVLEFTHNNTTVLLCNHSNSERGFLHEFCPI 248
            ::.::.|.:|||||.|:|:|::|||.:|||||||:||:.......|:||.|||:|||||.|...:
Mouse   288 ESQVKVVALCAGSGGSVLQGVEADLYLTGEMSHHDVLDAASKGINVILCEHSNTERGFLSELQEM 352

  Fly   249 LAKSLNEECLVFVSEVDKDPLVTV 272
            |......:..:.:||.|:|||..|
Mouse   353 LGVHFENKINIILSETDRDPLRVV 376

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG4278	NP_609790.1	NIF3	16..251	CDD:280036	111/323 (34%)
Nif3l1	NP_075364.2	NIF3	32..353	CDD:376614	110/321 (34%)
Nif3l1	NP_075364.2	Mediates interaction with COPS2. /evidence=ECO:0000269\|PubMed:12522100	243..376		52/132 (39%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0327
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H5881
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG54155
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0005738
OrthoInspector	1	1.000	-	-		oto94173
orthoMCL	1	0.900	-	-		OOG6_102764
Panther	1	1.100	-	-	LDO	PTHR13799
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R811
SonicParanoid	1	1.000	-	-		X4727
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	13	12.740