DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG3793 and PPM2

DIOPT Version :9

Sequence 1:	NP_001246038.1	Gene:	CG3793 / 34928	FlyBaseID:	FBgn0028507	Length:	341	Species:	Drosophila melanogaster
Sequence 2:	NP_014500.2	Gene:	PPM2 / 854024	SGDID:	S000005501	Length:	695	Species:	Saccharomyces cerevisiae

Alignment Length:	353	Identity:	85/353 - (24%)
Similarity:	159/353 - (45%)	Gaps:	37/353 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly    20 DEAVIATNDDASDCKRCAVRLGYWKD----------------DYIGYFVRNQERKAPEINRGYFA 68
            |.|:..||:.:...|| :|.|.|...                :|..:||..:.:::|.|||||:.
Yeast    24 DLAIQGTNNSSIASKR-SVELLYLPKLSSANNFQMDKNNKLLEYFKFFVPKKIKRSPCINRGYWL 87

  Fly    69 RVKGVEMCVEKFLKKTSGNCQI--INLGCGFDTLYFRLRDT-------AHQVKNFIELDFPTVTA 124
            |:..:...:...:::|..:.:|  :|||||:|.|.|:|.||       .|...:||::|:..:..
Yeast    88 RLFAIRSRLNSIIEQTPQDKKIVVVNLGCGYDPLPFQLLDTNNIQSQQYHDRVSFIDIDYSDLLK 152

  Fly   125 RKCYTIKRNKAL--LARIHDEDGEVRLSPTD-LHGPSYHLMGVDLRNLDEVDSKLQQAEV-DYSL 185
            .|...||....|  :..:.::...|..|..| |..|.|.....||.:.....:.|.:.:: |.::
Yeast   153 IKIELIKTIPELSKIIGLSEDKDYVDDSNVDFLTTPKYLARPCDLNDSKMFSTLLNECQLYDPNV 217

  Fly   186 PTIFLAECVLVYIEAQNCRNLLKWIAQKFQAAVFVNYEQV---NMNDRFGDVMLNNLRGRGCSLA 247
            ..:|:||..|.|::.:...:::: ...|.:.:.|:..||:   ...:.|...||.:.:.....|.
Yeast   218 VKVFVAEVSLAYMKPERSDSIIE-ATSKMENSHFIILEQLIPKGPFEPFSKQMLAHFKRNDSPLQ 281

  Fly   248 GVESCLSLDTQRNRFKDSGWTGARAWDMVQVYESISAAERQRIERLEMLDEGELLLQLFQHYCLV 312
            .|....::::|..||...|:......||.|::||...|.::.:.::|..||.|.......||.|.
Yeast   282 SVLKYNTIESQVQRFNKLGFAYVNVGDMFQLWESADEATKKELLKVEPFDELEEFHLFCHHYVLC 346

  Fly   313 VAWLGVAFQDIDITCVPVVEELMSSLNI 340
            .|   ..:::...|...:.:..:|.:|:
Yeast   347 HA---TNYKEFAFTQGFLFDRSISEINL 371

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG3793	NP_001246038.1	LCM	22..211	CDD:397957	54/217 (25%)
PPM2	NP_014500.2	AdoMet_MTases	7..241	CDD:418430	55/218 (25%)
		Kelch_4	439..486	CDD:404322
		KELCH repeat	440..487	CDD:276965
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	61	1.000	Domainoid score	I2539
eggNOG	1	0.900	-	-		E1_KOG2918
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0.815465	Normalized mean entropy	S2071
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0001575
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_100931
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R2177
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	7	6.690