Protein Alignment Gli and nlgn4xa

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: XP_021330915.1
• Gene: nlgn4xa / 561122
• ZFINID: ZDB-GENE-100309-2
• Length: 844
• Species: Danio rerio
• Alignment Length: 869
• Identity: 238/869 - (27%)
• Similarity: 361/869 - (41%)
• Gaps: 228/869 - (26%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            ||||||:::|.|     .|.|           :.::|....:||||||||||.|.||:||.....
Zfish    45 VTTNYGKLRGLK-----TPLP-----------NEILGPVEQYLGIPYALPPTGERRFQPPEPPMS 93

  Fly   202 WQ-LLQAVDFGPACPQ------------PVRYTG----ATKGIMDMDEDCLYLNVYSPKTGAGVA 249
            |. :..|..|.|.|||            ||.:|.    ....:.|..|||||||:|.|....| |
Zfish    94 WPGIRNATQFAPVCPQFLEDRFLLNDMLPVWFTANLDTVVTYVQDQSEDCLYLNIYVPTEDVG-A 157

  Fly   250 QK---------------------YPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGA 293
            .|                     .|||||||||.::.|..|:..|.||||:.:|:|||||||||.
Zfish   158 NKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVVTLNYRLGV 222

  Fly   294 LGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNI 358
            ||||||||:.:.||||:|||..||||:.:||:.|.||...:|:||.|||.:...||.::..:.::
Zfish   223 LGFLSTGDQAAKGNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGASCVSLLTLSHYSEDL 287

  Fly   359 VRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSP 423
            .::.|.|||:||:.||:   .|:....:|:|.:.:||::..|..||.||: .:::.||.....:.
Zfish   288 FQKAIIQSGTALSSWAV---NYQPAKYTRILAEKVGCNMLDSIDLVECLQ-NKNYKELIEQYITQ 348

  Fly   424 QVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFF 488
            ......:|||:|.: .:|.|                 |:.|:..|:| .|...|.||...|...|
Zfish   349 AKYHIAFGPVIDGD-VIPDD-----------------PQILMEQGEF-LNYDIMLGVNQGEGFKF 394

  Fly   489 V---AQNESLSPYYELDG---RFFDQKIREHV-FRYNYTLNPNGVYEAIKYIYTFWPDPNNNTII 546
            |   ..:|        ||   ..||..:.:.| ..|.|....:.:.|.||::||.|.|..|....
Zfish   395 VDGIVDSE--------DGVSANDFDFAVSDFVDHLYGYPEGKDTLRETIKFMYTDWADKENPETR 451

  Fly   547 RDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPF 611
            |...:.:.:|..:.||......|..:...|.|.|......::...|.|....|..|..::.|.|.
Zfish   452 RKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWSDSAHGDEVPYVFGIPM 516

  Fly   612 M-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIRY 672
            : .|:.|       ...::.||..:|...|..:||||:.|:   |.||....:|.:.....|:.:
Zfish   517 LGPTDLF-------NCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAW 574

  Fly   673 LNINTTYNSSILL------------NYRQTECAFWTQYLPTVIGV-------------------- 705
                :.||....|            :||.|:.|||.:.:|.:..:
Zfish   575 ----SKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNINELFQYVSTTTKIPPQDTTP 635

  Fly   706 ------LVPTYPPTTEYWWEPKEP---------------------------------LQIAFWSM 731
                  |..|:|.||.:   |..|                                 |.:.. ::
Zfish   636 FPYTKRLGKTWPSTTRH---PGVPPANTKQTTDQRKGNDLSDDSAVVIETKRDYSTELSVTI-AV 696

  Fly   732 SVACFFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDT-------RGVDNAHMVT-- 787
            ..:..||.:| ....:.::..||:.:.        |..|..|::::       ...|.||:.:
Zfish   697 GASLLFLNIL-AFAALYYKKDKRRHES--------NRRGPSPQRNSAPANVVANANDIAHLQSDE 752

  Fly   788 --------------NHH---ALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSPSSLAMTQKS-S 834
                          :||   :|::.|.:  ....|:..||..:...|...|.:||::.|...: :
Zfish   753 LMSLQMKQQQMEHEHHHECDSLQAHDTL--RLTCPADYTLTLRRSPDDIPLMTPSTITMIPNTLA 815

  Fly   835 SQASLKS----GISLKETN---GH 851
            ...:|.:    |.|...||   ||
Zfish   816 GMQTLHNFNTFGGSQNSTNLPHGH 839

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	197/618 (32%)
		PRK13335	818..>918	CDD:139494	11/42 (26%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:395084	197/618 (32%)