DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and nlgn4xa

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_021330915.1	Gene:	nlgn4xa / 561122	ZFINID:	ZDB-GENE-100309-2	Length:	844	Species:	Danio rerio

Alignment Length:	869	Identity:	238/869 - (27%)
Similarity:	361/869 - (41%)	Gaps:	228/869 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            ||||||:::|.|     .|.|           :.::|....:||||||||||.|.||:||.....
Zfish    45 VTTNYGKLRGLK-----TPLP-----------NEILGPVEQYLGIPYALPPTGERRFQPPEPPMS 93

  Fly   202 WQ-LLQAVDFGPACPQ------------PVRYTG----ATKGIMDMDEDCLYLNVYSPKTGAGVA 249
            |. :..|..|.|.|||            ||.:|.    ....:.|..|||||||:|.|....| |
Zfish    94 WPGIRNATQFAPVCPQFLEDRFLLNDMLPVWFTANLDTVVTYVQDQSEDCLYLNIYVPTEDVG-A 157

  Fly   250 QK---------------------YPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGA 293
            .|                     .|||||||||.::.|..|:..|.||||:.:|:|||||||||.
Zfish   158 NKGDDFTNNEGGENKDIHDENGLRPVMVYIHGGSYMEGTGNMIDGSILASYGNVIVVTLNYRLGV 222

  Fly   294 LGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNI 358
            ||||||||:.:.||||:|||..||||:.:||:.|.||...:|:||.|||.:...||.::..:.::
Zfish   223 LGFLSTGDQAAKGNYGLLDQIQALRWIKENIQAFKGDPKRVTIFGSGAGASCVSLLTLSHYSEDL 287

  Fly   359 VRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSP 423
            .::.|.|||:||:.||:   .|:....:|:|.:.:||::..|..||.||: .:::.||.....:.
Zfish   288 FQKAIIQSGTALSSWAV---NYQPAKYTRILAEKVGCNMLDSIDLVECLQ-NKNYKELIEQYITQ 348

  Fly   424 QVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFF 488
            ......:|||:|.: .:|.|                 |:.|:..|:| .|...|.||...|...|
Zfish   349 AKYHIAFGPVIDGD-VIPDD-----------------PQILMEQGEF-LNYDIMLGVNQGEGFKF 394

  Fly   489 V---AQNESLSPYYELDG---RFFDQKIREHV-FRYNYTLNPNGVYEAIKYIYTFWPDPNNNTII 546
            |   ..:|        ||   ..||..:.:.| ..|.|....:.:.|.||::||.|.|..|....
Zfish   395 VDGIVDSE--------DGVSANDFDFAVSDFVDHLYGYPEGKDTLRETIKFMYTDWADKENPETR 451

  Fly   547 RDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPF 611
            |...:.:.:|..:.||......|..:...|.|.|......::...|.|....|..|..::.|.|.
Zfish   452 RKTLVALFTDHQWVAPAVATADLHAQYGSPTYFYAFYHHCQSEMKPSWSDSAHGDEVPYVFGIPM 516

  Fly   612 M-DTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIRY 672
            : .|:.|       ...::.||..:|...|..:||||:.|:   |.||....:|.:.....|:.:
Zfish   517 LGPTDLF-------NCNFSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVAW 574

  Fly   673 LNINTTYNSSILL------------NYRQTECAFWTQYLPTVIGV-------------------- 705
                :.||....|            :||.|:.|||.:.:|.:..:
Zfish   575 ----SKYNPKDQLYLHIGLKPRVRDHYRATKVAFWLELVPHLHNINELFQYVSTTTKIPPQDTTP 635

  Fly   706 ------LVPTYPPTTEYWWEPKEP---------------------------------LQIAFWSM 731
                  |..|:|.||.:   |..|                                 |.:.. ::
Zfish   636 FPYTKRLGKTWPSTTRH---PGVPPANTKQTTDQRKGNDLSDDSAVVIETKRDYSTELSVTI-AV 696

  Fly   732 SVACFFLIVLVVICCIMWRNAKRQSDRFYDEDVFINGEGLEPEQDT-------RGVDNAHMVT-- 787
            ..:..||.:| ....:.::..||:.:.        |..|..|::::       ...|.||:.:
Zfish   697 GASLLFLNIL-AFAALYYKKDKRRHES--------NRRGPSPQRNSAPANVVANANDIAHLQSDE 752

  Fly   788 --------------NHH---ALRSRDNIYEYRDSPSTKTLASKAHTDTTSLRSPSSLAMTQKS-S 834
                          :||   :|::.|.:  ....|:..||..:...|...|.:||::.|...: :
Zfish   753 LMSLQMKQQQMEHEHHHECDSLQAHDTL--RLTCPADYTLTLRRSPDDIPLMTPSTITMIPNTLA 815

  Fly   835 SQASLKS----GISLKETN---GH 851
            ...:|.:    |.|...||   ||
Zfish   816 GMQTLHNFNTFGGSQNSTNLPHGH 839

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	197/618 (32%)
nlgn4xa	XP_021330915.1	COesterase	43..605	CDD:306613	197/618 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920