DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Gli and nlgn2a

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	XP_009301340.1	Gene:	nlgn2a / 556158	ZFINID:	ZDB-GENE-090918-2	Length:	828	Species:	Danio rerio

Alignment Length:	813	Identity:	233/813 - (28%)
Similarity:	350/813 - (43%)	Gaps:	189/813 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            ||||||:::|.|..:.                :.::|....:||:|||..|..:.||:||.....
Zfish    49 VTTNYGKLRGIKKELN----------------NEILGPVEQYLGVPYATAPIGDRRFQPPEAPGS 97

  Fly   202 WQ-LLQAVDFGPACPQ-----------PVRYTG----ATKGIMDMDEDCLYLNVYSPKTGAGVAQ 250
            || :..|..|.|.|||           ||.:|.    |...|.:..|||||||||.|.....:.:
Zfish    98 WQEVRNATQFAPVCPQNVHGVLPEIMLPVWFTDSLDVAATYIQNQSEDCLYLNVYVPTEDGPLTK 162

  Fly   251 KY-------------------PVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGF 296
            |:                   |||::||||.::.|..|:|...:||::.:|:|||:|||||.|||
Zfish   163 KHDESTLNRPRDEDIRDRRKKPVMLFIHGGSYMEGTGNMFDASVLAAYGNVIVVTMNYRLGVLGF 227

  Fly   297 LSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRR 361
            |||||:::.||||:|||..||||:.:||..|.||...||:||.|||.:...||:::..:..:.:|
Zfish   228 LSTGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQR 292

  Fly   362 VIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVG 426
            .|||||||::.|::   .|:....:::|.:.:||:...:..||:|||. ::|.||.:.:..|...
Zfish   293 AIAQSGSAISSWSI---SYQPLKYTKILARKVGCTYGETADLVDCLRR-KNFRELVDQDIQPARY 353

  Fly   427 SFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFV-- 489
            ...:|||:|.: .:|.|                 ||.|::.|:| .|...:.||...|...||
Zfish   354 HIAFGPVMDGD-VVPDD-----------------PEILMQQGEF-LNYDLLIGVNQGEGLKFVDD 399

  Fly   490 ---AQNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQY 550
               ...|.:|      ...||..|...|.. |.|....:.:.|.||::||.|.|.:|..:.|...
Zfish   400 GGTESEEGIS------AAAFDYTISNFVDNLYGYPKGKDILRETIKFMYTDWADRDNGEMRRKTL 458

  Fly   551 INMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFMD-T 614
            :.:.:|..:.||.....||..:.:.|||.|......:....|:|....|..|..::.|.|.:. |
Zfish   459 LALFTDHQWVAPAIATAKLHADYQSPVYFYTFYHHCQTETRPEWADAAHGDEIPYVFGVPMIGAT 523

  Fly   615 EFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIRYLNIN 676
            :.||..       ::.||..:|...|..:||||:.|:   |.||....:|.:.....|:    |.
Zfish   524 DLFPCN-------FSKNDIMLSAVVMTYWTNFAKTGDPNLPVPQDTKFIHTKPNRFEEV----IW 577

  Fly   677 TTYNSS------------ILLNYRQTECAFWTQYLP-------TVIGVLVPTYPP---TTEYW-- 717
            |.:||.            |..|||..:.|||.:.:|       .|........||   .|.:|
Zfish   578 TKFNSKDKQYLHIGLKPRIRDNYRANKVAFWLELVPHLHNLHEEVFSTATTRLPPGTARTPHWKG 642

  Fly   718 ----------------WEPKEPLQIAF-------------WSMSVA----CFFLIVLVVICCIMW 749
                            .:|....|..|             .|::||    ..||.:| ....:.:
Zfish   643 QGPRTTRHPIPTFPSELDPDSSEQPRFPPFPSDTRDYSTELSVTVAVGASLLFLNIL-AFAALYY 706

  Fly   750 RNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVTN--------------HH---ALRSRDN 797
            :..||...|.:         .|.|::.....|.||....              ||   .||..|.
Zfish   707 KRDKRHEMRRH---------RLSPQRGVAANDLAHSQEEEIMSLQMKHSEHDAHHDMEPLRPHDI 762

  Fly   798 IYEYRDS-PSTKTLASKAHTDTTSLRSPSSLAM 829
            :   |.: |...|||.:...|...|.:|:::.|
Zfish   763 L---RPACPPDYTLALRRAPDDVPLMTPNTITM 792

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	194/614 (32%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:306613	194/614 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D80457at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	LDO	PTHR43903
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	5	4.920