Protein Alignment Gli and nlgn2a

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: XP_009301340.1
• Gene: nlgn2a / 556158
• ZFINID: ZDB-GENE-090918-2
• Length: 828
• Species: Danio rerio
• Alignment Length: 813
• Identity: 233/813 - (28%)
• Similarity: 350/813 - (43%)
• Gaps: 189/813 - (23%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            ||||||:::|.|..:.                :.::|....:||:|||..|..:.||:||.....
Zfish    49 VTTNYGKLRGIKKELN----------------NEILGPVEQYLGVPYATAPIGDRRFQPPEAPGS 97

  Fly   202 WQ-LLQAVDFGPACPQ-----------PVRYTG----ATKGIMDMDEDCLYLNVYSPKTGAGVAQ 250
            || :..|..|.|.|||           ||.:|.    |...|.:..|||||||||.|.....:.:
Zfish    98 WQEVRNATQFAPVCPQNVHGVLPEIMLPVWFTDSLDVAATYIQNQSEDCLYLNVYVPTEDGPLTK 162

  Fly   251 KY-------------------PVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGF 296
            |:                   |||::||||.::.|..|:|...:||::.:|:|||:|||||.|||
Zfish   163 KHDESTLNRPRDEDIRDRRKKPVMLFIHGGSYMEGTGNMFDASVLAAYGNVIVVTMNYRLGVLGF 227

  Fly   297 LSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRR 361
            |||||:::.||||:|||..||||:.:||..|.||...||:||.|||.:...||:::..:..:.:|
Zfish   228 LSTGDQSAKGNYGLLDQIQALRWLNENIGHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQR 292

  Fly   362 VIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVG 426
            .|||||||::.|::   .|:....:::|.:.:||:...:..||:|||. ::|.||.:.:..|...
Zfish   293 AIAQSGSAISSWSI---SYQPLKYTKILARKVGCTYGETADLVDCLRR-KNFRELVDQDIQPARY 353

  Fly   427 SFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFV-- 489
            ...:|||:|.: .:|.|                 ||.|::.|:| .|...:.||...|...||
Zfish   354 HIAFGPVMDGD-VVPDD-----------------PEILMQQGEF-LNYDLLIGVNQGEGLKFVDD 399

  Fly   490 ---AQNESLSPYYELDGRFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQY 550
               ...|.:|      ...||..|...|.. |.|....:.:.|.||::||.|.|.:|..:.|...
Zfish   400 GGTESEEGIS------AAAFDYTISNFVDNLYGYPKGKDILRETIKFMYTDWADRDNGEMRRKTL 458

  Fly   551 INMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFMD-T 614
            :.:.:|..:.||.....||..:.:.|||.|......:....|:|....|..|..::.|.|.:. |
Zfish   459 LALFTDHQWVAPAIATAKLHADYQSPVYFYTFYHHCQTETRPEWADAAHGDEIPYVFGVPMIGAT 523

  Fly   615 EFFPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMHFQRAYQGEIRYLNIN 676
            :.||..       ::.||..:|...|..:||||:.|:   |.||....:|.:.....|:    |.
Zfish   524 DLFPCN-------FSKNDIMLSAVVMTYWTNFAKTGDPNLPVPQDTKFIHTKPNRFEEV----IW 577

  Fly   677 TTYNSS------------ILLNYRQTECAFWTQYLP-------TVIGVLVPTYPP---TTEYW-- 717
            |.:||.            |..|||..:.|||.:.:|       .|........||   .|.:|
Zfish   578 TKFNSKDKQYLHIGLKPRIRDNYRANKVAFWLELVPHLHNLHEEVFSTATTRLPPGTARTPHWKG 642

  Fly   718 ----------------WEPKEPLQIAF-------------WSMSVA----CFFLIVLVVICCIMW 749
                            .:|....|..|             .|::||    ..||.:| ....:.:
Zfish   643 QGPRTTRHPIPTFPSELDPDSSEQPRFPPFPSDTRDYSTELSVTVAVGASLLFLNIL-AFAALYY 706

  Fly   750 RNAKRQSDRFYDEDVFINGEGLEPEQDTRGVDNAHMVTN--------------HH---ALRSRDN 797
            :..||...|.:         .|.|::.....|.||....              ||   .||..|.
Zfish   707 KRDKRHEMRRH---------RLSPQRGVAANDLAHSQEEEIMSLQMKHSEHDAHHDMEPLRPHDI 762

  Fly   798 IYEYRDS-PSTKTLASKAHTDTTSLRSPSSLAM 829
            :   |.: |...|||.:...|...|.:|:::.|
Zfish   763 L---RPACPPDYTLALRRAPDDVPLMTPNTITM 792

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	194/614 (32%)
		PRK13335	818..>918	CDD:139494	3/12 (25%)
nlgn2a	XP_009301340.1	COesterase	47..608	CDD:395084	194/614 (32%)