Protein Alignment Gli and CES4A

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: XP_011521323.1
• Gene: CES4A / 283848
• HGNCID: 26741
• Length: 628
• Species: Homo sapiens
• Alignment Length: 643
• Identity: 172/643 - (26%)
• Similarity: 264/643 - (41%)
• Gaps: 165/643 - (25%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            |.|.||.:||.::::...|                   ..||||:|::.||....||.||.....
Human    52 VVTKYGTLQGKQMHVGKTP-------------------IQVFLGVPFSRPPLGILRFAPPEPPEP 97

  Fly   202 WQ-LLQAVDFGPA-----------------------------CPQPVRYTG-----------ATK 225
            |: :..|..:.|.                             .|||:...|           |:.
Human    98 WKGIRDATTYPPGWSLALSPGWSAVARSRLTATSASRVQASLLPQPLSIWGYRCLQESWGQLASM 162

  Fly   226 GI--------MDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDV 282
            .:        :...|||||||||:|....|..| .||||:..||.||.||::.::|..||:...|
Human   163 YVSTRERYKWLRFSEDCLYLNVYAPARAPGDPQ-LPVMVWFPGGAFIVGAASSYEGSDLAAREKV 226

  Fly   283 VVVTLNYRLGALGFL----STGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGG 343
            |:|.|.:|||..|||    .|.|.::.||:|:|||..|||||.:||..|.||..::||||..||.
Human   227 VLVFLQHRLGIFGFLRWRGRTDDSHARGNWGLLDQMAALRWVQENIAAFGGDPGNVTLFGQSAGA 291

  Fly   344 ASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVL------GQLLGCSIESSWK 402
            .|...||::|....:..|.|:|||:||         :|...||..|      ..|.||:..|:..
Human   292 MSISGLMMSPLASGLFHRAISQSGTAL---------FRLFITSNPLKVAKKVAHLAGCNHNSTQI 347

  Fly   403 LVNCLR--TGRS---------FYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRF 456
            ||||||  :|..         |.:| |.:..|:...:...||:| ...:|.|
Human   348 LVNCLRALSGTKVMRVSNKMRFLQL-NFQRDPEEIIWSMSPVVD-GVVIPDD------------- 397

  Fly   457 LTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPY---YELDGRFFDQKIREHVFRYN 518
                |..|:..||.: ::.|:.||...|..:       |.||   :.|:.:...::....:....
Human   398 ----PLVLLTQGKVS-SVPYLLGVNNLEFNW-------LLPYIMKFPLNRQAMRKETITKMLWST 450

  Fly   519 YTLNPNGVYEAIKYIYTFWPDPNNN---TIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMY 580
            .|| .|...|.:..:...:.|..|.   .::|::.::::.|..:.....|......:..:|||:|
Human   451 RTL-LNITKEQVPLVVEEYLDNVNEHDWKMLRNRMMDIVQDATFVYATLQTAHYHRDAGLPVYLY 514

  Fly   581 VLNTTVEALNL-PQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYT 644
            ........:.: |:.....|..|.|||.|.||.......|::.|...|            |:.:.
Human   515 EFEHHARGIIVKPRTDGADHGDEMYFLFGGPFATGLSMGKEKALSLQM------------MKYWA 567

  Fly   645 NFARYGNPT-------PQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFW 695
            ||||.|||.       |:          |..:.:||.::  :.:.:.:..::.:.|||
Human   568 NFARTGNPNDGNLPCWPR----------YNKDEKYLQLD--FTTRVGMKLKEKKMAFW 613

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	170/641 (27%)
CES4A	XP_011521323.1	COesterase	46..613	CDD:278561	170/641 (27%)
		Aes	<184..>291	CDD:223730	51/107 (48%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810