DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Gli and Ces2a

DIOPT Version :9

Sequence 1:	NP_476602.1	Gene:	Gli / 34927	FlyBaseID:	FBgn0001987	Length:	956	Species:	Drosophila melanogaster
Sequence 2:	NP_653344.1	Gene:	Ces2a / 246252	RGDID:	708353	Length:	558	Species:	Rattus norvegicus

Alignment Length:	644	Identity:	190/644 - (29%)
Similarity:	278/644 - (43%)	Gaps:	143/644 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   103 PNARTQFPG----VLAGWREDLQGKQRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRP 163
            |.||  .||    |..|....||....:||.:..|:    |:.|||:|..|::   .|.||   .
  Rat     2 PLAR--LPGWLYVVACGLLLLLQHVHGQDSASPIRN----THTGQVRGSFVHV---KDTKS---G 54

  Fly   164 YHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQAVDFGPA-CPQP-------VRY 220
            .|:           |||||:|.||....||.||.....|..::.....|| |.|.       ::.
  Rat    55 IHT-----------FLGIPFAKPPVGPLRFAPPEDPEPWSGVRDATSQPAMCLQTDIMNLDGIKE 108

  Fly   221 TGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVV 285
            ...|.....|.|||||||:|:| ..|......||||:||||..:.|::::.....||:..::|:|
  Rat   109 MKLTVHPTPMSEDCLYLNIYTP-AHAREGSNLPVMVWIHGGGLVLGSASMNDASTLAATEEIVIV 172

  Fly   286 TLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLM 350
            ::.||||.|||.||||:|:.||:|.|||..|||||..||.:|.|:...:|:||..|||.|....:
  Rat   173 SIQYRLGVLGFFSTGDQNARGNWGYLDQVAALRWVQQNIAYFGGNHGKVTIFGGSAGGTSVSSHV 237

  Fly   351 VAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYE 415
            |:|.::.:....|.|||.||.. .||.||  ::...:.:..|.||....|..|:.||| .:|..|
  Rat   238 VSPMSKGLFHGAIMQSGVALLP-DLISDK--SEVVYKTVANLSGCEAPDSEALIRCLR-AKSKQE 298

  Fly   416 L--GNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMT 478
            :  .|..|.                .:||        ..|.:||.:.|:.|:.:|.|: .:..:.
  Rat   299 ILAINQVFK----------------MIPG--------VVDGKFLPKHPQELLASGDFH-PVPSII 338

  Fly   479 GVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFR---------------YNYTLNPNGVYE 528
            |:.|.|..:      .:..:..||          |:.:               ....|.|    |
  Rat   339 GINTDECGW------GIPVFLGLD----------HIIKKITRETLPTVLKSTAAQMMLPP----E 383

  Fly   529 AIKYIY-TFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLP 592
            .|..|. .:..|..|...:::|:.:||.|..:..|..|:......| .|||.|      |..:||
  Rat   384 CIDLIMEEYMGDTENPETLQEQFRHMLGDFMFVIPALQVAHFQRSQ-APVYFY------EFQHLP 441

  Fly   593 QWRKY--PHDIER-----------YFLTGAPFMDTEFFPKKEHLQRNMWTDNDRNMSHFFMQTYT 644
            .:.|.  |..::.           .:|.|..|..||   ::|.|:|.:            |:.:.
  Rat   442 SFIKQVRPSHVKADHGDDILFVFGSYLWGMTFDLTE---EEELLKRRV------------MKYWA 491

  Fly   645 NFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVI 703
            ||||.|||..:.:  .|:......| :||.:||.......|..|:.:  |||:.||..|
  Rat   492 NFARTGNPNGEDL--PHWPVLDHDE-QYLQLNTQPAVGRALKARRLQ--FWTKTLPQKI 545

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	172/599 (29%)
Ces2a	NP_653344.1	COesterase	30..537	CDD:395084	173/604 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166336203
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.840