Protein Alignment Gli and Nlgn2

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_942562.2
• Gene: Nlgn2 / 216856
• MGIID: 2681835
• Length: 836
• Species: Mus musculus
• Alignment Length: 710
• Identity: 215/710 - (30%)
• Similarity: 316/710 - (44%)
• Gaps: 148/710 - (20%)

  Fly    74 GANYPGRNPPGQYPQGMPNEDRFRFDPNDPNARTQFPGVLAGWREDLQGKQRRDSLTLERDVFVT 138
            ||...|..|.|..|.|                    ||:..|            ||..||...|.
Mouse    13 GAQRGGGGPGGGAPGG--------------------PGLGLG------------SLGEERFPVVN 45

  Fly   139 TNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQ 203
            |.||:|:|.:                ....:.::|....|||:|||.||....||:||.....|.
Mouse    46 TAYGRVRGVR----------------RELNNEILGPVVQFLGVPYATPPLGARRFQPPEAPASWP 94

  Fly   204 -LLQAVDFGPACPQ-----------PVRYT----GATKGIMDMDEDCLYLNVY------------ 240
             :..|....|||||           ||.:|    .|...:.:..|||||||:|
Mouse    95 GVRNATTLPPACPQNLHGALPAIMLPVWFTDNLEAAATYVQNQSEDCLYLNLYVPTEDGPLTKKR 159

  Fly   241 ------SPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILASFYDVVVVTLNYRLGALGFLST 299
                  .|.|....:.|.|||:::|||.::.|..|:|.|.:||::.:|:|||||||||.||||||
Mouse   160 DEATLNPPDTDIRDSGKKPVMLFLHGGSYMEGTGNMFDGSVLAAYGNVIVVTLNYRLGVLGFLST 224

  Fly   300 GDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASAGLLMVAPQTRNIVRRVIA 364
            ||:.:.||||:|||..||||:.:||..|.||...||:||.|||.:...||:::..:..:.::.||
Mouse   225 GDQAAKGNYGLLDQIQALRWLSENIAHFGGDPERITIFGSGAGASCVNLLILSHHSEGLFQKAIA 289

  Fly   365 QSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSWKLVNCLRTGRSFYELGNAEFSPQVGSFP 429
            |||:|::.|::   .|:....:|:|...:||..|.|.:.|.|||. :|..||.:.:..|......
Mouse   290 QSGTAISSWSV---NYQPLKYTRLLAAKVGCDREDSTEAVECLRR-KSSRELVDQDVQPARYHIA 350

  Fly   430 WGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVTTQEAAFFV---AQ 491
            :|||:|.: .:|.|                 ||.|::.|:| .|...:.||...|...||   |:
Mouse   351 FGPVVDGD-VVPDD-----------------PEILMQQGEF-LNYDMLIGVNQGEGLKFVEDSAE 396

  Fly   492 NESLSPYYELDG---RFFDQKIREHVFR-YNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYIN 552
            :|        ||   ..||..:...|.. |.|....:.:.|.||::||.|.|.:|..:.|...:.
Mouse   397 SE--------DGVSASAFDFTVSNFVDNLYGYPEGKDVLRETIKFMYTDWADRDNGEMRRKTLLA 453

  Fly   553 MLSDLYYRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFMD-TEF 616
            :.:|..:.||.....||..:.:.|||.|......:|...|:|....|..|..::.|.|.:. |:.
Mouse   454 LFTDHQWVAPAVATAKLHADYQSPVYFYTFYHHCQAEGRPEWADAAHGDELPYVFGVPMVGATDL 518

  Fly   617 FPKKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGN---PTPQQVLGMH----------FQRAYQG 668
            ||..       ::.||..:|...|..:||||:.|:   |.||....:|          :.:....
Mouse   519 FPCN-------FSKNDVMLSAVVMTYWTNFAKTGDPNQPVPQDTKFIHTKPNRFEEVVWSKFNSK 576

  Fly   669 EIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVIGVLVPTYPPTTEY-----WWEPKEP 723
            |.:||:|.  ....:..|||..:.|||.:.:|.:..:....:..||..     .|.|:.|
Mouse   577 EKQYLHIG--LKPRVRDNYRANKVAFWLELVPHLHNLHTELFTTTTRLPPYATRWPPRTP 634

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	193/612 (32%)
		PRK13335	818..>918	CDD:139494
Nlgn2	NP_942562.2	COesterase	42..601	CDD:395084	193/614 (31%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	623..661		3/12 (25%)
		Required for interaction with LHFPL4. /evidence=ECO:0000269|PubMed:28279354	679..699
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	711..735
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	791..836