Protein Alignment Gli and cest-13

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_741921.1
• Gene: cest-13 / 181493
• WormBaseID: WBGene00010116
• Length: 548
• Species: Caenorhabditis elegans
• Alignment Length: 606
• Identity: 161/606 - (26%)
• Similarity: 236/606 - (38%)
• Gaps: 143/606 - (23%)

  Fly   164 YHSTVDRVMGECSV----------FLGIPYALPPTFEGRFKPPRVHRGWQLLQAVDFGPACPQPV 218
            |..||....|..::          |.||.||.||....||...|......|::|..:|..|   |
 Worm    23 YDVTVQTPNGSATIRGIQHTYGTSFRGIRYAQPPVGLFRFGAARRLDPVGLVEAQAYGNIC---V 84

  Fly   219 RYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHI--LASFYD 281
            :..|.|.     .||||::|||:| .....|.|.||.||||||.|:.|..|:..|..  |.:...
 Worm    85 QGDGRTS-----HEDCLFINVYTP-NNVTQASKLPVYVYIHGGGFVEGGGNMGAGIYPNLVNKGP 143

  Fly   282 VVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAGGASA 346
            :|:|::|||||..||.||....:|||:.|.|...||.||...|.||.||.|.:|:.|..:|..:.
 Worm   144 IVMVSINYRLGPFGFFSTRQMTAPGNWAISDWIEALNWVQRYISFFGGDPNRVTIGGQSSGAEAV 208

  Fly   347 GLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRVLGQLLGCSIESSW-------KLV 404
            ..|.:.|..:|:.::.|.:||||... |::....:.::||:.|...|||:....|       .::
 Worm   209 STLTLTPLAKNLFKQSIHESGSAFGA-AVMSYSEKTRSTSKQLSIKLGCATSDQWDNGQSFGTIL 272

  Fly   405 NCLRTGRSFYELGNAEFSPQVGSFPWGPVLDHNFTLPGDDWYEGWREK-----DWRFLTQTPETL 464
            .|||         |..:...|.:               |:...|.|.|     |.::|||..|.|
 Worm   273 TCLR---------NVTYDKIVAA---------------DNSLPGHRMKWSIVQDNKYLTQRLEYL 313

  Fly   465 IRAGKFNRNIQYMTGVTTQEAAFFVAQN----------------ESLSPYYELDGRFFDQKIREH 513
            .......:|:  :.|....|...:...|                :.||..||:  .::|.|....
 Worm   314 ALQRDPKKNV--LIGDVHDEWLGWEMNNVLHNINSSHNTAHQMRDDLSGSYEM--TYWDNKQSVL 374

  Fly   514 VFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRD---QYINMLSDLYYRAPVDQMVKLMLEQKV 575
            |...|..:|..|           |.|.|:    |:   :.|.:.|::.:..|..:........|.
 Worm   375 VAADNKYINNQG-----------WTDDNH----REWEARRIQLWSEMVFIGPTLRDAAYFQYMKN 424

  Fly   576 PVYMYVLNTTVEALNLPQWRKYPHDIERYFLTGAPFMDTEFFPKKEHLQRNMW------------ 628
            .||:|.|:          |...|         ..|.:....|...||    .|
 Worm   425 NVYLYSLD----------WLSPP---------ALPLVTDPLFRGCEH----TWELQYIFSTSCNG 466

  Fly   629 ---TDNDRNMSHFFMQTYTNFARYGNPTPQQVLG--MHFQ-RAYQGEIRYLNINTTYNSSILLNY 687
               |..|..:.::|..|:.||...|||||   .|  :.|: .|.....|:|:.:.  |..:..:|
 Worm   467 FTCTAQDEILRNYFTTTWLNFIIGGNPTP---AGSPLPFKWLAMDSTNRFLSFSP--NPKMQPHY 526

  Fly   688 RQTECAFWTQYLPTVIGVLVP 708
             ..:..||....||:.|...|
 Worm   527 -HPDSMFWVCTAPTIDGYKGP 546

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	155/591 (26%)
		PRK13335	818..>918	CDD:139494
cest-13	NP_741921.1	alpha/beta hydrolases	24..526	CDD:473884	153/582 (26%)