Protein Alignment Gli and cest-5.2

DIOPT Version :10

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_501021.3
• Gene: cest-5.2 / 177428
• WormBaseID: WBGene00015284
• Length: 583
• Species: Caenorhabditis elegans
• Alignment Length: 577
• Identity: 134/577 - (23%)
• Similarity: 224/577 - (38%)
• Gaps: 164/577 - (28%)

  Fly   137 VTTNYGQVQGFKVYMYDNPDPKSFYRPYHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRG 201
            :.|:.|:::|                       :..|:..:|..||:|.||....||:.|.....
 Worm    24 IKTSLGRLEG-----------------------KQSGKYQLFRRIPFAKPPIGTLRFQKPESAEK 65

  Fly   202 WQ-LLQAVDFGPACPQPVRYTGATKGIMDMDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIR 265
            |. :..|.::||||.....:|.:.:  ..:|||||::|::: ......::...|:|||||||.:.
 Worm    66 WNGVWNATEYGPACMSNSTWTQSPQ--KWVDEDCLHVNIFT-SDKCLKSKDCAVVVYIHGGEIVF 127

  Fly   266 GASNLFQG-HILASF--YDVVVVTLNYRLGALGFLSTGDEN-SPGNYGILDQAMALRWVYDNIEF 326
            .::.:|.. .:|.||  .||::|...:|||.....:..|:| :|.|..:.|..:|..:|...|..
 Worm   128 DSAVMFNDTFLLESFVKQDVILVIPAFRLGIFSHFTVHDQNIAPNNLALYDIILAQEFVKSEIHN 192

  Fly   327 FNGDRNSITLFGPGAGGASAGLLMVAP---QTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRV 388
            |.||...|||||...||..|.::..:.   |..::.:|:|..|.:...|..    :.:.:.:.||
 Worm   193 FGGDIQKITLFGHSYGGTIASMMAFSSEINQDLSLFQRIIVMSANQYFDTL----EEQIERSDRV 253

  Fly   389 LGQLLGCSIESSWK-----------LVNCLR---------TGRSFYELGNAEFSPQVGSFPWGPV 433
            : :..|||:.::..           ::.||:         ..||..|.|    .|.:|
 Worm   254 V-KHAGCSVPTNLARKMNRSQKEKYMMKCLQKLSGMELLSVQRSLEEAG----YPDIG------- 306

  Fly   434 LDHNFTLPGDDWYEGWREKDWRFLTQTPETLIRAGKFNRNIQYMTGVT-----TQEAAFFVAQNE 493
               |..|.|.           .|...|...::.:.|.   |..:.|.|     .::...|:.::.
 Worm   307 ---NLVLRGP-----------LFPDVTSLEMLESPKM---IPMLAGCTKFESDDEDETHFIGKHF 354

  Fly   494 SLSPYYELDGRFFDQKIREHVFRYNYTLNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLY 558
            .|....|.     |:|.|:.:        .||:::            ..|...:.|.|.:.:.|
 Worm   355 GLENPIEC-----DEKYRKDL--------ENGIFD------------RQNHSDKTQAIMVPTKL- 393

  Fly   559 YRAPVDQMVKLMLEQKVPVYMYVLNTTVEALNLPQWRKYP----HDIERYFLTGA-PFMDTEFFP 618
               .|||:.|    ..||.|:|...             ||    |..:.|::.|. ||...|
 Worm   394 ---RVDQLRK----HGVPAYLYEFT-------------YPKHAFHTDDLYYIMGIHPFEKDE--- 435

  Fly   619 KKEHLQRNMWTDNDRNMSHFFMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNI 675
            .:|||::..     |||       ..||.::|.|      ||.|:.:...|..|..|
 Worm   436 NEEHLEKVY-----RNM-------LINFIKFGEP------GMGFEMSDLNESTYFEI 474

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	137..695	CDD:395084	134/577 (23%)
		PRK13335	818..>918	CDD:139494
cest-5.2	NP_501021.3	alpha/beta hydrolases	21..498	CDD:473884	134/577 (23%)