Protein Alignment Gli and Ces2a

DIOPT Version :9

• Sequence 1: NP_476602.1
• Gene: Gli / 34927
• FlyBaseID: FBgn0001987
• Length: 956
• Species: Drosophila melanogaster
• Sequence 2: NP_598721.1
• Gene: Ces2a / 102022
• MGIID: 2142491
• Length: 558
• Species: Mus musculus
• Alignment Length: 650
• Identity: 188/650 - (28%)
• Similarity: 278/650 - (42%)
• Gaps: 155/650 - (23%)

  Fly   103 PNARTQFPG----VLAGWREDLQGKQRRDSLTLERDVFVTTNYGQVQGFKVYMYDNPDPKSFYRP 163
            |.||  .||    |..|....||....:||.:..|:    |:.|||:|..|::   .|.||   .
Mouse     2 PLAR--LPGWLCVVACGLLLLLQHVHGQDSASPIRN----THRGQVRGSFVHV---KDTKS---G 54

  Fly   164 YHSTVDRVMGECSVFLGIPYALPPTFEGRFKPPRVHRGWQLLQAVDFGPA-CPQPVRYTGATKGI 227
            .|:           |||||:|.||....||.||.....|..::.....|| |.||        .|
Mouse    55 VHA-----------FLGIPFAKPPVGLLRFAPPEDPEPWSGVRDGTSQPAMCLQP--------DI 100

  Fly   228 MD---------------MDEDCLYLNVYSPKTGAGVAQKYPVMVYIHGGEFIRGASNLFQGHILA 277
            |:               |.|||||||:|:| |.|......||||:||||..:.|::::.....||
Mouse   101 MNLEDAKEMNLILPPISMSEDCLYLNIYTP-THAQEGSNLPVMVWIHGGGLVVGSASMNDVSKLA 164

  Fly   278 SFYDVVVVTLNYRLGALGFLSTGDENSPGNYGILDQAMALRWVYDNIEFFNGDRNSITLFGPGAG 342
            :..::|:|.:.||||.|||.||||:::.||:|.|||..|||||..||.:|.|:|:.:|:||..||
Mouse   165 ATEEIVIVAIQYRLGVLGFFSTGDQHARGNWGYLDQVAALRWVQKNIAYFGGNRDRVTIFGVSAG 229

  Fly   343 GASAGLLMVAPQTRNIVRRVIAQSGSALADWALIQDKYRAQNTSRV----LGQLLGCSIESSWKL 403
            |.|....:::|.::.:....|.|||.||.. .||.|      ||.|    :..|.||....|..|
Mouse   230 GTSVSSHILSPMSKGLFHGAIMQSGVALLP-DLISD------TSEVVYKTVANLSGCEATDSEAL 287

  Fly   404 VNCLRTGRSFYEL--GNAEFS--PQVGSFPWGPVLDHNFTLPGDDWYEGWREKDWRFLTQTPETL 464
            ::||| .:|..|:  .|..|.  |.|                          .|..||.:.|:.|
Mouse   288 IHCLR-AKSKQEILAINQVFKMIPAV--------------------------VDGEFLPKHPQEL 325

  Fly   465 IRAGKFNRNIQYMTGVTTQEAAFFVAQNESLSPYYELDGRFFDQKIREHVFRYNYT--------- 520
            :.:..|: .:..:.||.|.|..:.|.....|                :|:.: |.|
Mouse   326 LTSMDFH-PVPSIIGVNTDECGWGVPMFMGL----------------DHIIK-NITRETLPAVLK 372

  Fly   521 -------LNPNGVYEAIKYIYTFWPDPNNNTIIRDQYINMLSDLYYRAPVDQMVKLMLEQKVPVY 578
                   |.|...:..::   .:..|..:...::.|:..||.|..:..|..|:......| .|||
Mouse   373 NTAARMMLPPECSHLLVE---EYMGDTEDPETLQAQFREMLGDFMFVIPALQVAHFQRSQ-APVY 433

  Fly   579 MYV---LNTTVEALNLPQWRKYPHDIERYFLTGAPF--MDTEFFPKKEHLQRNMWTDNDRNMSHF 638
            .|.   |::.::.:. |...|..|..:..|:.|:..  |:.:...::|.|:|.|
Mouse   434 FYEFQHLSSFIKHVR-PSHVKADHGDDVAFVFGSYLWDMNLDLTEEEELLKRMM----------- 486

  Fly   639 FMQTYTNFARYGNPTPQQVLGMHFQRAYQGEIRYLNINTTYNSSILLNYRQTECAFWTQYLPTVI 703
             |:.:.||||.|||..:   |:........:.:||.::|.......|..|:.:  |||:.||..|
Mouse   487 -MKYWANFARNGNPNSE---GLPSWPVLDHDEQYLQLDTQPAVGRALKARRLQ--FWTKTLPQKI 545

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Gli	NP_476602.1	COesterase	134..695	CDD:278561	170/605 (28%)
Ces2a	NP_598721.1	COesterase	30..537	CDD:278561	171/610 (28%)
		Aes	<127..>230	CDD:223730	48/103 (47%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832674
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG1516
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	4	3.740