Protein Alignment CycE and CCND2

DIOPT Version :10

• Sequence 1: NP_001246037.1
• Gene: CycE / 34924
• FlyBaseID: FBgn0010382
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_001750.1
• Gene: CCND2 / 894
• HGNCID: 1583
• Length: 289
• Species: Homo sapiens
• Alignment Length: 365
• Identity: 79/365 - (21%)
• Similarity: 139/365 - (38%)
• Gaps: 123/365 - (33%)

  Fly   337 LMCH---------RDE---QDSR-LRSISMLEQ------------HPGLQPRMRAILLDWLIEVC 376
            |:||         ||.   :|.| |:::..:|:            ...:||.||.::..|::|||
Human     3 LLCHEVDPVRRAVRDRNLLRDDRVLQNLLTIEERYLPQCSYFKCVQKDIQPYMRRMVATWMLEVC 67

  Fly   377 EVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIYPPKIGEFAYVTDGAC 441
            |..|...|.|.||::||||:| ......|:||||:|..|:|:|:|::|..|....:....||.:.
Human    68 EEQKCEEEVFPLAMNYLDRFL-AGVPTPKSHLQLLGAVCMFLASKLKETSPLTAEKLCIYTDNSI 131

  Fly   442 TERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQIGRQKSAEADDAFIYPQF 506
            ..:::|..|.::|..|.|:::.:|...::...::.....|...|..:
Human   132 KPQELLEWELVVLGKLKWNLAAVTPHDFIEHILRKLPQQREKLSLIR------------------ 178

  Fly   507 SGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREMALRCSGLDWQVIQPCARWMEPFF 571
               :..||  .:.||..|...|.|..|::|..::.       |..| ||
Human   179 ---KHAQT--FIALCATDFKFAMYPPSMIATGSVG-------AAIC-GL---------------- 214

  Fly   572 RVISQKAPYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMDMYDEVLMAQDAAHAMRA 636
                         :|:|:||:     |.|                            ||...:.|
Human   215 -------------QQDEEVSS-----LTC----------------------------DALTELLA 233

  Fly   637 RIQASPATALRA----PESLLTPPASSHKPDEYLGDEGDE 672
            :|..:....|:|    .|::|......::.|:..|.:.::
Human   234 KITNTDVDCLKACQEQIEAVLLNSLQQYRQDQRDGSKSED 273

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	CYCLIN_CCNE_rpt1	327..459	CDD:410223	46/146 (32%)
		CYCLIN_CCNE_rpt2	463..576	CDD:410224	16/112 (14%)
CCND2	NP_001750.1	CYCLIN_SF	1..150	CDD:477360	46/147 (31%)
		CYCLIN_CCND2_rpt2	155..259	CDD:410280	30/196 (15%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	264..289		2/10 (20%)