Protein Alignment CycE and CCNB3

DIOPT Version :10

• Sequence 1: NP_001246037.1
• Gene: CycE / 34924
• FlyBaseID: FBgn0010382
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: XP_016885402.1
• Gene: CCNB3 / 85417
• HGNCID: 18709
• Length: 1404
• Species: Homo sapiens
• Alignment Length: 452
• Identity: 112/452 - (24%)
• Similarity: 175/452 - (38%)
• Gaps: 82/452 - (18%)

  Fly   121 NEDP----ELGF-------EPPSAKRQQRLPALYGSEQG---NLSSVA-------SSVYTSPVVS 164
            ||.|    ||.|       |.|:.|....|..|...:.|   |:||.|       ||:.|...|.
Human   934 NEKPTTGKELSFKEPLALQESPTYKEDTFLKTLLVPQVGTSPNVSSTAPESITSKSSIATMTSVG 998

  Fly   165 VDGQST-----QELLSIRSSPAEDLSEAPHSPLPDSPDSPPSPDRGSKQTPVVVRYAAEQVVTST 224
            ..|...     ::::::...|......:...||. ..:||...:....:|.::.:......|.||
Human   999 KSGTINEAFLFEDMITLNEKPTTGKELSFKEPLA-LQESPTCKEDTFLETFLIPQIGTSPYVFST 1062

  Fly   225 VVTQKTEDDDLLDDSCEDYSYDEDDEDDVEEEDDDVEIYSSTISPASSGCSQQQAVNGERTPGLP 289
            .....||...:...:....|....:....|...|      ..:||.:.|..::|.     ||
Human  1063 TPESITEKSSIATMTSVGKSRTTTESSACESASD------KPVSPQAKGTPKEQI-----TP--- 1113

  Fly   290 KHQEQIHHPVSDLMINMRTPMSPAVENGLRQCPLPALAWANAADVWRLMCHRD-EQDSRLRSISM 353
              :|.|....||...|   ||                   .|.:::..|..|: |:.::.....:
Human  1114 --REDIDEDSSDPSFN---PM-------------------YAKEIFSYMKEREIEETAQSHEQFI 1154

  Fly   354 LEQHPGLQ----PRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGIT 414
            |..:...|    ..|||||:|||:||...:::..||.||||..:|.||..| ..:|..|||:|.|
Human  1155 LTDYMNRQIEITSDMRAILVDWLVEVQVSFEMTHETLYLAVKLVDLYLMKA-VCKKDKLQLLGAT 1218

  Fly   415 CLFVAAKVEEIYPPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQ-LNV 478
            ...:|||.||...|::.:|.|:.|......::|:.|..:|..|..||:......:|..|.: ::.
Human  1219 AFMIAAKFEEHNSPRVDDFVYICDDNYQRSEVLSMEINILNVLKCDINIPIAYHFLRRYARCIHT 1283

  Fly   479 NNRTPASFSQIGRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVG-----MANYS-YSV 534
            |.:|......|......|    :.|.|....:....|.||.|....:|     :.:|| ||:
Human  1284 NMKTLTLSRYICEMTLQE----YHYVQEKASKLAAASLLLALYMKKLGYWVPFLEHYSGYSI 1341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	CYCLIN_CCNE_rpt1	327..459	CDD:410223	45/136 (33%)
		CYCLIN_CCNE_rpt2	463..576	CDD:410224	17/79 (22%)
CCNB3	XP_016885402.1	CYCLIN_CCNB3_rpt1	1116..1264	CDD:410212	51/170 (30%)
		CYCLIN_SF	1268..1382	CDD:477360	17/78 (22%)