Protein Alignment CycE and CCND1

DIOPT Version :10

• Sequence 1: NP_001246037.1
• Gene: CycE / 34924
• FlyBaseID: FBgn0010382
• Length: 712
• Species: Drosophila melanogaster
• Sequence 2: NP_444284.1
• Gene: CCND1 / 595
• HGNCID: 1582
• Length: 295
• Species: Homo sapiens
• Alignment Length: 305
• Identity: 70/305 - (22%)
• Similarity: 120/305 - (39%)
• Gaps: 83/305 - (27%)

  Fly   362 PRMRAILLDWLIEVCEVYKLHRETFYLAVDYLDRYLHVAHKVQKTHLQLIGITCLFVAAKVEEIY 426
            |.||.|:..|::||||..|...|.|.||::||||:|.: ..|:|:.|||:|.||:|||:|::|..
Human    54 PSMRKIVATWMLEVCEEQKCEEEVFPLAMNYLDRFLSL-EPVKKSRLQLLGATCMFVASKMKETI 117

  Fly   427 PPKIGEFAYVTDGACTERDILNHEKILLQALDWDISPITITGWLGVYMQLNVNNRTPASFSQ--I 489
            |....:....||.:....::|..|.:|:..|.|:::.:                 ||..|.:  :
Human   118 PLTAEKLCIYTDNSIRPEELLQMELLLVNKLKWNLAAM-----------------TPHDFIEHFL 165

  Fly   490 GRQKSAEADDAFIYPQFSGFEFVQTSQLLDLCTLDVGMANYSYSVLAAAAISHTFSREMALRCSG 554
            .:...||.:...|......|        :.||..||...:...|::||.::
Human   166 SKMPEAEENKQIIRKHAQTF--------VALCATDVKFISNPPSMVAAGSV-------------- 208

  Fly   555 LDWQVIQPCARWMEPFFRVISQKAPYLQLNEQNEQVSNKFGLGLICPNIVTDDSHIIQTHTTTMD 619
                                               |:...||.|..||      :.:..:..|..
Human   209 -----------------------------------VAAVQGLNLRSPN------NFLSYYRLTRF 232

  Fly   620 MYDEVLMAQDAAHAMRARIQASPATALRAPESLLTPPASSHKPDE 664
            :...:....|...|.:.:|:|...::||..:..:.|.|:..:.:|
Human   233 LSRVIKCDPDCLRACQEQIEALLESSLRQAQQNMDPKAAEEEEEE 277

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
CycE	NP_001246037.1	CYCLIN_CCNE_rpt1	327..459	CDD:410223	39/96 (41%)
		CYCLIN_CCNE_rpt2	463..576	CDD:410224	14/114 (12%)
CCND1	NP_444284.1	CYCLIN_CCND1_rpt1	3..151	CDD:410276	39/97 (40%)
		CYCLIN_CCND1_rpt2	156..265	CDD:410279	27/171 (16%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	262..295		3/16 (19%)